Search Results - "Jenoe, Paul"
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GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing
Published in Science (American Association for the Advancement of Science) (16-03-2018)“…Malaria is caused by parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only…”
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2
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Published in Science (American Association for the Advancement of Science) (15-03-2013)“…The Ser-Thr kinase mammalian target of rapamycin (mTOR) controls cell growth and metabolism by stimulating glycolysis and synthesis of proteins and lipids. To…”
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3
Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient
Published in Proceedings of the National Academy of Sciences - PNAS (02-02-2016)“…Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways and their mechanisms of activation remain largely unknown. We…”
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4
Allosteric Control of Cyclic di-GMP Signaling
Published in The Journal of biological chemistry (20-10-2006)“…Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of…”
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5
Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control
Published in Molecular cell (01-09-2002)“…The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin-sensitive manner. TOR2…”
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6
Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes
Published in PloS one (28-12-2017)“…Basement membranes (BMs) are specialized sheets of extracellular matrix that outline epithelial cell layers, muscle fibers, blood vessels, and peripheral…”
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7
A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology
Published in PLoS pathogens (01-02-2010)“…The heterochromatic environment and physical clustering of chromosome ends at the nuclear periphery provide a functional and structural framework for antigenic…”
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8
NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1
Published in Proceedings of the National Academy of Sciences - PNAS (03-08-2010)“…GABA B receptors are the G-protein–coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. GABA B receptors are abundant on dendritic…”
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9
Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment
Published in PloS one (04-11-2011)“…The contribution of aberrant DNA methylation in silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic…”
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10
Correction: Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes
Published in PloS one (06-04-2018)“…[This corrects the article DOI: 10.1371/journal.pone.0189857.]…”
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11
Quantitative proteomics of Spodoptera frugiperda cells during growth and baculovirus infection
Published in PloS one (18-10-2011)“…Baculovirus infection of Spodoptera frugiperda cells is a system of choice to produce a range of recombinant proteins, vaccines and, potentially, gene therapy…”
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12
Quantitation of Changes in Protein Phosphorylation: A Simple Method Based on Stable Isotope Labeling and Mass Spectrometry
Published in Proceedings of the National Academy of Sciences - PNAS (04-02-2003)“…Reversible protein phosphorylation plays an important role in many cellular processes. However, a simple and reliable method to measure changes in the extent…”
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13
Identification of the rapamycin-sensitive phosphorylation sites within the Ser/Thr-rich domain of the yeast Npr1 protein kinase
Published in Rapid communications in mass spectrometry (15-12-2008)“…The Saccharomyces cerevisae nitrogen permease reactivator Npr1 is a hyperphosphorylated protein that belongs to a fungus‐specific family of Ser/Thr protein…”
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14
A Modified KESTREL Search Reveals a Basophilic Substrate Consensus for the Saccharomyces cerevisiae Npr1 Protein Kinase
Published in Journal of proteome research (06-11-2009)“…The Saccharomyces cerevisiae nitrogen permease reactivator Npr1 is a hyperphosphorylated protein that belongs to a family of Ser/Thr protein kinases dedicated…”
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15
Plasmodium falciparum Possesses a Cell Cycle-regulated Short Type Replication Protein A Large Subunit Encoded by an Unusual Transcript
Published in The Journal of biological chemistry (17-05-2002)“…DNA replication in Plasmodium parasites takes place at multiple distinct points during their complex life cycle in the mosquito and vertebrate hosts. Although…”
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Negative Regulation of Phosphatidylinositol 4,5-Bisphosphate Levels by the INP51-associated Proteins TAX4 and IRS4
Published in The Journal of biological chemistry (17-09-2004)“…Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an important second messenger in signaling pathways in organisms ranging from yeast to mammals, but the…”
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Use of Two-Dimensional Electrophoresis To Study Differential Protein Expression in Divercin V41-Resistant and Wild-Type Strains of Listeria monocytogenes
Published in Applied and Environmental Microbiology (01-10-2000)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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18
The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates
Published in Molecular biology of the cell (01-10-2010)“…Regulation of cell growth requires extensive coordination of several processes including transcription, ribosome biogenesis, translation, nutrient metabolism,…”
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19
The protein histidine phosphatase LHPP is a tumour suppressor
Published in Nature (London) (29-03-2018)“…Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular…”
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TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis
Published in Molecular biology of the cell (15-03-2013)“…The evolutionarily conserved Orm1 and Orm2 proteins mediate sphingolipid homeostasis. However, the homologous Orm proteins and the signaling pathways…”
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