Search Results - "Jenny, P."

The NLRP3 inflammasome: molecular activation and regulation to therapeutics by Swanson, Karen V., Deng, Meng, Ting, Jenny P.-Y.

“…NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals…”
Get full text

The inflammasome NLRs in immunity, inflammation, and associated diseases by Davis, Beckley K, Wen, Haitao, Ting, Jenny P-Y

“…Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup…”
Get full text

The pathogenic role of the inflammasome in neurodegenerative diseases by Freeman, Leslie C., Ting, Jenny P.‐Y.

“…The inflammasome is a large macromolecular complex that contains multiple copies of a receptor or sensor of pathogen‐derived or damage‐derived molecular…”
Get full text

A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases by Barnett, Katherine C., Li, Sirui, Liang, Kaixin, Ting, Jenny P.-Y.

“…Inflammasomes are critical sentinels of the innate immune system that respond to threats to the host through recognition of distinct molecules, known as…”
Get full text

Inflammasomes: mechanism of action, role in disease, and therapeutics by Guo, Haitao, Callaway, Justin B, Ting, Jenny P-Y

“…The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious…”
Get full text

The NLR gene family: from discovery to present day by Chou, Wei-Chun, Jha, Sushmita, Linhoff, Michael W., Ting, Jenny P.-Y.

“…The mammalian NLR gene family was first reported over 20 years ago, although several genes that were later grouped into the family were already known at that…”
Get full text

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation by Wen, Haitao, Miao, Edward A., Ting, Jenny P.-Y.

“…A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome…”
Get full text

Changes in Light Absorptivity of Molecular Weight Separated Brown Carbon Due to Photolytic Aging by Wong, Jenny P. S, Nenes, Athanasios, Weber, Rodney J

“…Brown carbon (BrC) consists of those organic compounds in atmospheric aerosols that absorb solar radiation and may play an important role in planetary…”
Get full text

Novel role of PKR in inflammasome activation and HMGB1 release by Lu, Ben, Nakamura, Takahisa, Inouye, Karen, Li, Jianhua, Tang, Yiting, Lundbäck, Peter, Valdes-Ferrer, Sergio I., Olofsson, Peder S., Kalb, Thomas, Roth, Jesse, Zou, Yongrui, Erlandsson-Harris, Helena, Yang, Huan, Ting, Jenny P.-Y., Wang, Haichao, Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Hotamisligil, Gökhan S., Tracey, Kevin J.

“…Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release…”
Get full text

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes by Freeman, Leslie, Guo, Haitao, David, Clément N, Brickey, W June, Jha, Sushmita, Ting, Jenny P-Y

“…Inflammation in the brain accompanies several high-impact neurological diseases including multiple sclerosis (MS), stroke, and Alzheimer's disease…”
Get full text

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING by Zhang, Lu, Mo, Jinyao, Swanson, Karen V., Wen, Haitao, Petrucelli, Alex, Gregory, Sean M., Zhang, Zhigang, Schneider, Monika, Jiang, Yan, Fitzgerald, Katherine A., Ouyang, Songying, Liu, Zhi-Jie, Damania, Blossom, Shu, Hong-Bing, Duncan, Joseph A., Ting, Jenny P.-Y.

“…Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction…”
Get full text

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3 by Li, Hanfen, Willingham, Stephen B, Ting, Jenny P.-Y, Re, Fabio

“…Alum is the only adjuvant approved for routine use in humans, although the basis for its adjuvanticity remains poorly understood. We have recently shown that…”
Get full text

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses by Wang, Menglin, Rousseau, Benoit, Qiu, Kunyu, Huang, Guannan, Zhang, Yu, Su, Hang, Le Bihan-Benjamin, Christine, Khati, Ines, Artz, Oliver, Foote, Michael B., Cheng, Yung-Yi, Lee, Kuo-Hsiung, Miao, Michael Z., Sun, Yue, Bousquet, Philippe-Jean, Hilmi, Marc, Dumas, Elise, Hamy, Anne-Sophie, Reyal, Fabien, Lin, Lin, Armistead, Paul M., Song, Wantong, Vargason, Ava, Arthur, Janelle C., Liu, Yun, Guo, Jianfeng, Zhou, Xuefei, Nguyen, Juliane, He, Yongqun, Ting, Jenny P.-Y., Anselmo, Aaron C., Huang, Leaf

“…Increasing evidence implicates the tumor microbiota as a factor that can influence cancer progression. In patients with colorectal cancer (CRC), we found that…”
Get full text

STING-induced regulatory B cells compromise NK function in cancer immunity by Li, Sirui, Mirlekar, Bhalchandra, Johnson, Brandon M., Brickey, W. June, Wrobel, John A., Yang, Na, Song, Dingka, Entwistle, Sarah, Tan, Xianming, Deng, Meng, Cui, Ya, Li, Wei, Vincent, Benjamin G., Gale, Michael, Pylayeva-Gupta, Yuliya, Ting, Jenny P.-Y.

“…An immunosuppressive tumour microenvironment is a major obstacle in the control of pancreatic and other solid cancers 1 – 3 . Agonists of the stimulator of…”
Get full text

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation? by Wen, Haitao, Ting, Jenny P-Y, O'Neill, Luke A J

“…The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC…”
Get full text

Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways by Wang, Ying, Li, Sirui, Hu, Mengying, Yang, Yuchen, McCabe, Ellie, Zhang, Lillian, Withrow, Andrew M., Ting, Jenny P.-Y., Liu, Rihe

“…The efficacy of STING (stimulator of interferon genes) agonists is due to various factors, primarily inefficient intracellular delivery, low/lack of endogenous…”
Get full text

DJ-1, a Cancer- and Parkinson's Disease-Associated Protein, Stabilizes the Antioxidant Transcriptional Master Regulator Nrf2 by Clements, Casey M., McNally, Richard S., Conti, Brian J., Mak, Tak W., Ting, Jenny P. -Y.

“…DJ-1/PARK7, a cancer- and Parkinson's disease (PD)-associated protein, protects cells from toxic stresses. However, the functional basis of this protection has…”
Get full text

Role of Aerosol Liquid Water in Secondary Organic Aerosol Formation from Volatile Organic Compounds by Faust, Jennifer A, Wong, Jenny P. S, Lee, Alex K. Y, Abbatt, Jonathan P. D

“…A key mechanism for atmospheric secondary organic aerosol (SOA) formation occurs when oxidation products of volatile organic compounds condense onto…”
Get full text

The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis by Truax, Agnieszka D., Chen, Liang, Tam, Jason W., Cheng, Ning, Guo, Hao, Koblansky, A. Alicia, Chou, Wei-Chun, Wilson, Justin E., Brickey, W. June, Petrucelli, Alex, Liu, Rongrong, Cooper, Daniel E., Koenigsknecht, Mark J., Young, Vincent B., Netea, Mihai G., Stienstra, Rinke, Sartor, R. Balfour, Montgomery, Stephanie A., Coleman, Rosalind A., Ting, Jenny P.-Y.

“…In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12,…”
Get full text

Rethinking data treatment: The sucrose preference threshold for anhedonia in stress-induced rat models of depression by Berrio, Jenny P., Kalliokoski, Otto

“…Exposing rats to repeated unpredictable stressors is a popular method for modelling depression. The sucrose preference test is used to assess the validity of…”
Get full text