Search Results - "Jennings F. Worley III"

Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms by McKay, M C, Worley, 3rd, J F

“…Linoleic acid (LA) had two effects on human Kv1.5 and Kv2.1 channels expressed in Chinese hamster ovary cells: an increase in the speed of current activation…”
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Synthesis and evaluation of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives as KATP channel agonists by PEAT, Andrew J, TOWNSEND, Claire, THOMSON, Stephen A, WORLEY, Jennings F, ALLEN, Scott H, GARRIDO, Dulce, MERTZ, Robert J, PFOHL, Jeffrey L, TERRY, Christopher M, TRUAX, Jim F, VEASEY, Robert L

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An industrial perspective on utilizing functional ion channel assays for high throughput screening by Worley, 3rd, Jennings F, Main, Martin J

“…The ability to apply large-scale screening formats to measures of ion channel function offers immense opportunities for drug discovery and academic research…”
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Activation of Stimulus-Secretion Coupling in Pancreatic -Cells by Specific Products of Glucose Metabolism by Robert J. Mertz, Jennings F. Worley III, Ben Spencer, John H. Johnson, Iain D. Dukes

“…The energy requirements of most cells supplied with glucose are fulfilled by glycolytic and oxidative metabolism, yielding ATP. In pancreatic β-cells, a rise…”
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Characterization of a Ca2+ Release-activated Nonselective Cation Current Regulating Membrane Potential and [Ca2+] i Oscillations in Transgenically Derived β-Cells by Michael W. Roe, Jennings F. Worley III, Feng Qian, Natalia Tamarina, Anshu A. Mittal, Flora Dralyuk, Nathaniel T. Blair, Robert J. Mertz, Louis H. Philipson, Iain D. Dukes

“…Although stimulation of insulin secretion by glucose is regulated by coupled oscillations of membrane potential and intracellular Ca 2+ ([Ca 2+ ] i ), the…”
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Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine by Strobl, J S, Kirkwood, K L, Lantz, T K, Lewine, M A, Peterson, V A, Worley, 3rd, J F

“…Permanent cell culture lines derived from human breast cancer tissue are important experimental models in the study of human breast cancer cell proliferation…”
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Expression and Function of Pancreatic β-Cell Delayed Rectifier K+ Channels by Michael Wm. Roe, Jennings F. Worley III, Anshu A. Mittal, Andrey Kuznetsov, Sarmila DasGupta, Robert J. Mertz, Sam M. Witherspoon III, Nathaniel Blair, Mary E. Lancaster, Margaret S. McIntyre, W. Ronald Shehee, Iain D. Dukes, Louis H. Philipson

“…Voltage-dependent delayed rectifier K + channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles…”
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