Search Results - "Jennifer A. Sandberg"

The encapsulation of ribozymes in biodegradable polymeric matrices by Jackson, John K, Liang, Linda S, Hunter, William L, Reynolds, Mark, Sandberg, Jennifer A, Springate, Chris, Burt, Helen M

“…Ribozymes are catalytic RNA that bind and cleave specific regions of target RNA. Therefore, protein synthesis by the target RNA may be specifically inhibited…”
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Pharmacokinetics and Tolerability of an Antiangiogenic Ribozyme (ANGIOZYME™) in Healthy Volunteers by Sandberg, Jennifer A., Parker, Vann P., Blanchard, Karin S., Sweedler, David, Powell, James A., Kachensky, Arlee, Bellon, Laurent, Usman, Nassim, Rossing, Thomas, Borden, Ernest, Blatt, Lawrence M.

“…The pharmacokinetics and tolerability of a chemically stabilized synthetic ribozyme (ANGIOZYME™) targeting the Flt‐1 VEGF receptor mRNA were evaluated in…”
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Quantitative exposure assessment: application of physiologically-based pharmacokinetic (PBPK) modeling of low-dose, long-term exposures of organic acid toxicant in the brain by Kim, Chung S, Sandberg, Jennifer A, Slikker, William, Binienda, Zbigniew, Schlosser, Paul M, Patterson, Tucker A

“…Our objective was to construct a physiologically-based pharmacokinetic (PBPK) model describing the kinetic behavior of 2,4-dichlorophenoxyacetic acid (2,4-D)…”
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Temporal development of 2′,3′-dideoxyinosine (ddI)–induced peripheral myelinopathy by Patterson, Tucker A, Schmued, Larry C, Sandberg, Jennifer A, Slikker, William

“…The anti-HIV therapeutic dideoxyinosine (ddI) has been reported to produce a painful, dose-limiting peripheral myelinopathy in HIV-infected patients after…”
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Effects of fumonisin B 1 treatment on blood-brain barrier transfer in developing rats by Kwon, Oh-Seung, Sandberg, Jennifer A., Slikker, William

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Transplacental Pharmacokinetics and Fetal Distribution of Azidothymidine, Its Glucuronide, and Phosphorylated Metabolites in Late-Term Rhesus Macaques after Maternal Infusion by Tucker A. Patterson, Zbigniew K. Binienda, George W. Lipe, Michael P. Gillam, William Slikker, Jr, Jennifer A. Sandberg

“…3′-Azido-3′-deoxythymidine (AZT) is currently prescribed to pregnant women infected with human immunodeficiency virus to reduce the risk of vertical…”
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Quantitative low-dose assessment of seafood toxin, domoic acid, in the rat brain: application of physiologically-based pharmacokinetic (PBPK) modeling by Kim, Chung S, Ross, Ivan A, Sandberg, Jennifer A, Preston, Edward

“…The purpose of this study was to construct a physiologically based pharmacokinetic model and demonstrate its ability to predict low-dose uptake of domoic acid,…”
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Pharmacokinetics and Tissue Distribution of a Ribozyme Directed Against Hepatitis C Virus RNA Following Subcutaneous or Intravenous Administration in Mice by Lee, Patrice A., Blatt, Lawrence M., Blanchard, Karin S., Bouhana, Karyn S., Pavco, Pamela A., Bellon, Laurent, Sandberg, Jennifer A.

“…A nuclease resistant ribozyme targeting the 5′ untranslated region (5′ UTR) of hepatitis C virus (HCV) at site 195 has been identified. To investigate the…”
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Transplacental pharmacokinetics and fetal distribution of 2′,3′-didehydro-3′-deoxythymidine (d4T) and its metabolites in late-term rhesus macaques by Patterson, Tucker A., Binienda, Zbigniew K., Newport, Glenn D., Lipe, George W., Gillam, Michael P., Slikker Jr, William, Sandberg, Jennifer A.

“…Background The overall goal of human immunodeficiency virus (HIV) therapy during pregnancy is to maintain maternal health and reduce the probability of…”
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Quantitative Determination of a Chemically Modified Hammerhead Ribozyme in Blood Plasma Using 96-Well Solid-Phase Extraction Coupled with High-Performance Liquid Chromatography or Capillary Gel Electrophoresis by Bellon, Laurent, Maloney, Lara, Zinnen, Shawn P., Sandberg, Jennifer A., Johnson, Kevin E.

“…Versatile bioanalytical assays to detect chemically stabilized hammerhead ribozyme and putative ribozyme metabolites from plasma are described. The extraction…”
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Developmental pharmacology and toxicology of anti-HIV therapeutic agents: dideoxynucleosides by Sandberg, J A, Slikker, Jr, W

“…As the incidence of human immunodeficiency virus (HIV) infection has increased in women over the past decade, the need for safe, effective therapy during…”
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Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats by Kwon, Oh-Seung, Sandberg, Jennifer A., Slikker, William

“…Fumonisin B1 (FB1), a toxic metabolite of the fungus Fusarium moniliforme found in contaminated corn, is considered an etiologic agent of equine…”
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Alterations in electroencephalographic signals and monoamine concentrations in the rat brain following cocaine and methamphetamine treatment by Binienda, Z, Sandberg, J A, Slikker, Jr, W, Ali, S F

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Evaluation of brain and nerve pathology in rats chronically dosed with ddI or isoniazid by Schmued, Larry C., Albertson, Christopher M., Andrews, Annette, Sandberg, Jennifer A., Nickols, Jess, Slikker, William

“…The antiviral adenosine analog, 2′,3′-dideoxyinosine (ddI), and the antitubercular nicotinic acid analogue, isoniazid, have recently received widespread…”
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Distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) in maternal and fetal rabbits by Sandberg, J A, Duhart, H M, Lipe, G, Binienda, Z, Slikker, Jr, W, Kim, C S

“…The distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) was examined in maternal and fetal rabbits. Pregnant New Zealand rabbits (28-30 d gestational age)…”
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Pharmacokinetics of an antiangiogenic ribozyme (ANGIOZYME) in the mouse by Sandberg, J A, Bouhana, K S, Gallegos, A M, Agrawal, A B, Grimm, S L, Wincott, F E, Reynolds, M A, Pavco, P A, Parry, T J

“…Vascular endothelial growth factor (VEGF) is a growth factor that contributes to the angiogenesis of developing tumors. To interfere with the action of VEGF, a…”
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Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey by Sandberg, J A, Sproul, C D, Blanchard, K S, Bellon, L, Sweedler, D, Powell, J A, Caputo, F A, Kornbrust, D J, Parker, V P, Parry, T J, Blatt, L M

“…The potential acute toxicity of a ribozyme (ANGIOZYME) targeting the flt-1 vascular endothelial growth factor (VEGF) receptor mRNA was evaluated in cynomolgus…”
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