Search Results - "Jenkinson, Eric"

An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells by White, Andrea J, Jenkinson, William E, Cowan, Jennifer E, Parnell, Sonia M, Bacon, Andrea, Jones, Nick D, Jenkinson, Eric J, Anderson, Graham

“…In the thymus, interactions with both cortical and medullary microenvironments regulate the development of self-tolerant conventional CD4(+) and CD8(+) αβT…”
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Generation of both cortical and Aire+ medullary thymic epithelial compartments from CD205+ progenitors by Baik, Song, Jenkinson, Eric J., Lane, Peter J. L., Anderson, Graham, Jenkinson, William E.

“…In the adult thymus, the development of self‐tolerant thymocytes requires interactions with thymic epithelial cells (TECs). Although both cortical and…”
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The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development by Cowan, Jennifer E, Parnell, Sonia M, Nakamura, Kyoko, Caamano, Jorge H, Lane, Peter J L, Jenkinson, Eric J, Jenkinson, William E, Anderson, Graham

“…A key role of the thymic medulla is to negatively select autoreactive CD4(+) and CD8(+) thymocytes, a process important for T cell tolerance induction…”
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Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium by Rossi, Simona W, Jenkinson, William E, Jenkinson, Eric J, Anderson, Graham

“…The thymus provides an essential environment for the development of T cells from haemopoietic progenitors. This environment is separated into cortical and…”
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RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla by Rossi, Simona W, Kim, Mi-Yeon, Leibbrandt, Andreas, Parnell, Sonia M, Jenkinson, William E, Glanville, Stephanie H, McConnell, Fiona M, Scott, Hamish S, Penninger, Josef M, Jenkinson, Eric J, Lane, Peter J L, Anderson, Graham

“…Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the…”
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Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium by Roberts, Natalie A., White, Andrea J., Jenkinson, William E., Turchinovich, Gleb, Nakamura, Kyoko, Withers, David R., McConnell, Fiona M., Desanti, Guillaume E., Benezech, Cecile, Parnell, Sonia M., Cunningham, Adam F., Paolino, Magdalena, Penninger, Josef M., Simon, Anna Katharina, Nitta, Takeshi, Ohigashi, Izumi, Takahama, Yousuke, Caamano, Jorge H., Hayday, Adrian C., Lane, Peter J.L., Jenkinson, Eric J., Anderson, Graham

“…The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing…”
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Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence by Kvell, Krisztian, Varecza, Zoltan, Bartis, Domokos, Hesse, Sebastian, Parnell, Sonia, Anderson, Graham, Jenkinson, Eric J, Pongracz, Judit E

“…Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to…”
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Generating intrathymic microenvironments to establish T-cell tolerance by Anderson, Graham, Lane, Peter J. L, Jenkinson, Eric J

“…Alphabeta T cells pass through a series of lymphoid tissue stromal microenvironments to acquire self tolerance and functional competence. In the thymus,…”
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Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells by White, Andrea J, Nakamura, Kyoko, Jenkinson, William E, Saini, Manoj, Sinclair, Charles, Seddon, Benedict, Narendran, Parth, Pfeffer, Klaus, Nitta, Takeshi, Takahama, Yousuke, Caamano, Jorge H, Lane, Peter J L, Jenkinson, Eric J, Anderson, Graham

“…The thymic medulla represents a key site for the induction of T cell tolerance. In particular, autoimmune regulator (Aire)-expressing medullary thymic…”
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Lymphostromal interactions in thymic development and function by Anderson, Graham, Jenkinson, Eric J

“…The generation of a peripheral T-cell pool is essential for normal immune system function. CD4+ and CD8+ T cells are produced most efficiently in the thymus,…”
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Checkpoints in the Development of Thymic Cortical Epithelial Cells by Shakib, Saba, Desanti, Guillaume E, Jenkinson, William E, Parnell, Sonia M, Jenkinson, Eric J, Anderson, Graham

“…In the thymus, interactions between immature thymocytes and thymic epithelial cells (TECs) regulate the development and selection of self-tolerant…”
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Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive alpha beta T Cells in the Adult Thymus by Cowan, Jennifer E, McCarthy, Nicholas I, Parnell, Sonia M, White, Andrea J, Bacon, Andrea, Serge, Arnauld, Irla, Magali, Lane, Peter JL, Jenkinson, Eric J, Jenkinson, William E, Anderson, Graham

“…alpha beta T cell development depends upon serial migration of thymocyte precursors through cortical and medullary microenvironments, enabling specialized…”
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Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla by Desanti, Guillaume E, Cowan, Jennifer E, Baik, Song, Parnell, Sonia M, White, Andrea J, Penninger, Josef M, Lane, Peter J L, Jenkinson, Eric J, Jenkinson, William E, Anderson, Graham

“…T cell tolerance in the thymus is a key step in shaping the developing T cell repertoire. Thymic medullary epithelial cells play multiple roles in this…”
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Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development by McCarthy, Nicholas I, Cowan, Jennifer E, Nakamura, Kyoko, Bacon, Andrea, Baik, Song, White, Andrea J, Parnell, Sonia M, Jenkinson, Eric J, Jenkinson, William E, Anderson, Graham

“…In the thymus, medullary thymic epithelial cells (mTEC) regulate T cell tolerance via negative selection and Foxp3(+) regulatory T cell (Treg) development, and…”
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Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool by Nakamura, Kyoko, White, Andrea J, Parnell, Sonia M, Lane, Peter J, Jenkinson, Eric J, Jenkinson, William E, Anderson, Graham

“…Thymocytes expressing the invariant Vγ5 γδT-cell receptor represent progenitors of dendritic epidermal T-cells (DETC) that play an important immune…”
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Normal T cell selection occurs in CD205-deficient thymic microenvironments by Jenkinson, William E, Nakamura, Kyoko, White, Andrea J, Jenkinson, Eric J, Anderson, Graham

“…The thymus imparts a developmental imprint upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities. Cortical thymic epithelial…”
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Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input by White, Andrea J, Withers, David R, Parnell, Sonia M, Scott, Hamish S, Finke, Daniela, Lane, Peter J.L, Jenkinson, Eric J, Anderson, Graham

“…Intrathymic deletion of immature thymocytes that express self-reactive TCR specificities is essential in the generation of self tolerance. Medullary thymic…”
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Redefining epithelial progenitor potential in the developing thymus by Rossi, Simona W, Chidgey, Ann P, Parnell, Sonia M, Jenkinson, William E, Scott, Hamish S, Boyd, Richard L, Jenkinson, Eric J, Anderson, Graham

“…Cortical and medullary epithelium represent specialised cell types that play key roles in thymocyte development, including positive and negative selection of…”
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An Epithelial Progenitor Pool Regulates Thymus Growth by Jenkinson, William E, Bacon, Andrea, White, Andrea J, Anderson, Graham, Jenkinson, Eric J

“…Thymic epithelium provides an essential cellular substrate for T cell development and selection. Gradual age-associated thymic atrophy leads to a reduction in…”
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roadmap for thymic epithelial cell development by Anderson, Graham, Jenkinson, Eric J, Rodewald, Hans-Reimer

“…Thymic epithelial cells (TEC) are essential components of the thymus that guide and control the development and TCR repertoire selection of T cells…”
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