Colonoscopy and chromoscopy in hereditary colorectal cancer syndromes

Colonoscopy and chromoscopy in hereditary colorectal cancer syndromes

With hereditary colorectal cancer prevention studies it is difficult to demonstrate reduced mortality. Large populations are needed with well characterized genetics followed over a long period of time. Those studies do exist for standard white light colonoscopy surveillance in Lynch syndrome, but no...

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Bibliographic Details
Published in:Familial cancer Vol. 15; no. 3; pp. 453 - 455
Main Authors: Jenkins Wessling, Erin, Lanspa, Stephen J.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-07-2016
Springer Nature B.V
Subjects:
Adenoma - diagnosis
Adenoma - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Capsule Endoscopes
Capsule Endoscopy
Colonoscopes
Colonoscopy - methods
Colonoscopy - trends
Colorectal cancer
Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control
Coloring Agents - administration & dosage
Early Detection of Cancer - methods
Early Detection of Cancer - trends
Epidemiology
Human Genetics
Humans
Original Article
Precision Medicine - methods
Adenomas
Chromoscopy
Indigo carmine
Lynch syndrome
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Description
Summary:With hereditary colorectal cancer prevention studies it is difficult to demonstrate reduced mortality. Large populations are needed with well characterized genetics followed over a long period of time. Those studies do exist for standard white light colonoscopy surveillance in Lynch syndrome, but not for newer technologies including chromoscopy. For these newer technologies adenoma detection rate becomes the stand-in for mortality, and the assumption is made that surveillance efficacy impacts cancer occurrence. Though well-designed and important work exists in this area, the data do not support firm conclusions regarding the use of chromoscopy in Lynch syndrome.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1389-9600
1573-7292
DOI:10.1007/s10689-016-9881-9