Search Results - "Jenkins, NA"

Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity by Tsui, CC, Copeland, NG, Gilbert, DJ, Jenkins, NA, Barnes, C, Worley, PF

“…Stimulus-linked RNA and protein synthesis is required for establishment of long-term neuroplasticity. To identify molecular mechanisms underlying long-term…”
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Melanocytes and the microphthalmia transcription factor network by Steingrímsson, Eiríkur, Copeland, Neal G, Jenkins, Nancy A

“…The first mouse microphthalmia transcription factor (Mitf ) mutation was discovered over 60 years ago, and since then over 24 spontaneous and induced mutations…”
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A highly efficient recombineering-based method for generating conditional knockout mutations by Liu, Pentao, Jenkins, Nancy A, Copeland, Neal G

“…Phage-based Escherichia coli homologous recombination systems have recently been developed that now make it possible to subclone or modify DNA cloned into…”
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2 by Ramonet, David, Daher, João Paulo L, Lin, Brian M, Stafa, Klodjan, Kim, Jaekwang, Banerjee, Rebecca, Westerlund, Marie, Pletnikova, Olga, Glauser, Liliane, Yang, Lichuan, Liu, Ying, Swing, Deborah A, Beal, M Flint, Troncoso, Juan C, McCaffery, J Michael, Jenkins, Nancy A, Copeland, Neal G, Galter, Dagmar, Thomas, Bobby, Lee, Michael K, Dawson, Ted M, Dawson, Valina L, Moore, Darren J

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to…”
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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death by Martin, Lee J, Pan, Yan, Price, Ann C, Sterling, Wanda, Copeland, Neal G, Jenkins, Nancy A, Price, Donald L, Lee, Michael K

“…Alpha-synuclein (alpha-Syn) is enriched in nerve terminals. Two mutations in the alpha-Syn gene (Ala53--> Thr and Ala30--> Pro) occur in autosomal dominant…”
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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1 , PRDM16 or SETBP1 by von Kalle, Christof, Grez, Manuel, Ott, Marion G, Schmidt, Manfred, Schwarzwaelder, Kerstin, Stein, Stefan, Siler, Ulrich, Koehl, Ulrike, Glimm, Hanno, Kühlcke, Klaus, Schilz, Andrea, Kunkel, Hana, Naundorf, Sonja, Brinkmann, Andrea, Deichmann, Annette, Fischer, Marlene, Ball, Claudia, Pilz, Ingo, Dunbar, Cynthia, Du, Yang, Jenkins, Nancy A, Copeland, Neal G, Lüthi, Ursula, Hassan, Moustapha, Thrasher, Adrian J, Hoelzer, Dieter, Seger, Reinhard

“…Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults…”
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Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells by Du, Yang, Jenkins, Nancy A., Copeland, Neal G.

“…Retroviruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valuable molecular tags for cancer gene discovery. Here…”
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Plasma metabolomics of children with aberrant serum lipids and inadequate micronutrient intake by Li, Katherine J, Jenkins, NaNet, Luckasen, Gary, Rao, Sangeeta, Ryan, Elizabeth P

“…Blood lipids have served as key biomarkers for cardiovascular disease (CVD) risk, yet emerging evidence indicates metabolite profiling might reveal a larger…”
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Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase by Jankowsky, Joanna L., Fadale, Daniel J., Anderson, Jeffrey, Xu, Guilian M., Gonzales, Victoria, Jenkins, Nancy A., Copeland, Neal G., Lee, Michael K., Younkin, Linda H., Wagner, Steven L., Younkin, Steven G., Borchelt, David R.

“…Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and γ-secretase to release amyloid peptides (Aβ40 and 42) that aggregate to form…”
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RTCGD: retroviral tagged cancer gene database by Akagi, Keiko, Suzuki, Takeshi, Stephens, Robert M., Jenkins, Nancy A., Copeland, Neal G.

“…Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a potent cancer gene discovery tool in the post‐genome‐sequence era. To manage…”
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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals by Montcouquiol, Mireille, Rachel, Rivka A, Lanford, Pamela J, Copeland, Neal G, Jenkins, Nancy A, Kelley, Matthew W

“…In mammals, an example of planar cell polarity (PCP) is the uniform orientation of the hair cell stereociliary bundles within the cochlea. The PCP pathway of…”
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Gene Therapy Insertional Mutagenesis Insights by Davé, Utpal P., Jenkins, Nancy A., Copeland, Neal G.

“…In a milestone study describing the first "cure" of a genetic disease by retroviral gene therapy, nine out of ten infants born with X-linked severe combined…”
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Structure‐function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2 by Simon, R., Baumann, L., Fischer, J., Seigfried, F. A., De Bruyckere, E., Liu, P., Jenkins, N. A., Copeland, N. G., Schwegler, H., Britsch, S.

“…The dentate gyrus is one of the only two brain regions where adult neurogenesis occurs. Throughout life, cells of the neuronal stem cell niche undergo…”
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Recombineering: a powerful new tool for mouse functional genomics by Copeland, Neal G, Jenkins, Nancy A, Court, Donald L

“…Highly efficient phage-based Escherichia coli homologous recombination systems have recently been developed that enable genomic DNA in bacterial artificial…”
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Human α-Synuclein-Harboring Familial Parkinson's Disease-Linked Ala-53 → Thr Mutation Causes Neurodegenerative Disease with α-Synuclein Aggregation in Transgenic Mice by Lee, Michael K., Stirling, Wanda, Xu, Yanqun, Xu, Xueying, Qui, Dike, Mandir, Allen S., Dawson, Ted M., Copeland, Neal G., Jenkins, Nancy A., Price, Don L.

“…Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of pedigrees with familial PD. Moreover, α-Syn accumulates as a major…”
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Bcl11a is essential for normal lymphoid development by Copeland, Neal G, Liu, Pentao, Keller, Jonathan R, Ortiz, Mariaestela, Tessarollo, Lino, Rachel, Rivka A, Nakamura, Takuro, Jenkins, Nancy A

“…Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal…”
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An Efficient Recombination System for Chromosome Engineering in Escherichia coli by Yu, Daiguan, Ellis, Hilary M., E-Chiang Lee, Jenkins, Nancy A., Copeland, Neal G., Court, Donald L.

“…A recombination system has been developed for efficient chromosome engineering in Escherichia coli by using electroporated linear DNA. A defective λ prophage…”
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School screening programs to identify hypertension in Hispanic youth by Pollack, Austin M., Hamilton, Landon D., Jenkins, NaNet A., Lueders, Paige C., Luckasen, Gary J.

“…Elevated blood pressure during childhood can lead to hypertension in adulthood and is associated with an increased risk of future cardiovascular disease with…”
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New genes involved in cancer identified by retroviral tagging by Copeland, Neal G, Suzuki, Takeshi, Shen, Haifa, Akagi, Keiko, Morse, Herbert C, Malley, James D, Naiman, Daniel Q, Jenkins, Nancy A

“…Retroviral insertional mutagenesis in BXH2 and AKXD mice induces a high incidence of myeloid leukemia and B- and T-cell lymphoma, respectively. The retroviral…”
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Deciphering the genetic landscape of cancer – from genes to pathways by Copeland, Neal G, Jenkins, Nancy A

“…Advances in genomic technologies have made it possible to screen the entire cancer genome for mutations, leading to a better understanding of the genetic…”
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