Search Results - "Jenkins, Meredith L"

Expanding the Scope of Electrophiles Capable of Targeting K‑Ras Oncogenes by McGregor, Lynn M, Jenkins, Meredith L, Kerwin, Caitlin, Burke, John E, Shokat, Kevan M

“…There is growing interest in reversible and irreversible covalent inhibitors that target noncatalytic amino acids in target proteins. With a goal of targeting…”
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Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus by Jenkins, Meredith L., Ranga-Prasad, Harish, Parson, Matthew A. H., Harris, Noah J., Rathinaswamy, Manoj K., Burke, John E.

“…PIK3CA encoding the phosphoinositide 3-kinase (PI3K) p110α catalytic subunit is frequently mutated in cancer, with mutations occurring widely throughout the…”
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Recognition of protein-linked glycans as a determinant of peptidase activity by Noach, Ilit, Ficko-Blean, Elizabeth, Pluvinage, Benjamin, Stuart, Christopher, Jenkins, Meredith L., Brochu, Denis, Buenbrazo, Nakita, Wakarchuk, Warren, Burke, John E., Gilbert, Michel, Boraston, Alisdair B.

“…The vast majority of proteins are posttranslationally altered, with the addition of covalently linked sugars (glycosylation) being one of the most abundant…”
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Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation by Choi, Yong Mi, Ajjaji, Dalila, Fleming, Kaelin D., Borbat, Peter P., Jenkins, Meredith L., Moeller, Brandon E., Fernando, Shaveen, Bhatia, Surita R., Freed, Jack H., Burke, John E., Thiam, Abdou Rachid, Airola, Michael V.

“…Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and…”
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Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin by Haji-Ghassemi, Omid, Gilbert, Michel, Spence, Jenifer, Schur, Melissa J., Parker, Matthew J., Jenkins, Meredith L., Burke, John E., van Faassen, Henk, Young, N. Martin, Evans, Stephen V.

“…Aberrant glycosylation and the overexpression of specific carbohydrate epitopes is a hallmark of many cancers, and tumor-associated oligosaccharides are…”
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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 by Jenkins, Meredith L., Margaria, Jean Piero, Stariha, Jordan T. B., Hoffmann, Reece M., McPhail, Jacob A., Hamelin, David J., Boulanger, Martin J., Hirsch, Emilio, Burke, John E.

“…The GTPase Rab11 plays key roles in receptor recycling, oogenesis, autophagosome formation, and ciliogenesis. However, investigating Rab11 regulation has been…”
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Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane by Ulengin-Talkish, Idil, Parson, Matthew A. H., Jenkins, Meredith L., Roy, Jagoree, Shih, Alexis Z. L., St-Denis, Nicole, Gulyas, Gergo, Balla, Tamas, Gingras, Anne-Claude, Várnai, Péter, Conibear, Elizabeth, Burke, John E., Cyert, Martha S.

“…Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a critical mediator of Ca 2+ signaling. Here, to discover…”
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An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S] by Pulkoski-Gross, Michael J., Jenkins, Meredith L., Truman, Jean-Philip, Salama, Mohamed F., Clarke, Christopher J., Burke, John E., Hannun, Yusuf A., Obeid, Lina M.

“…Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular…”
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Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication by McPhail, Jacob A, Lyoo, Heyrhyoung, Pemberton, Joshua G, Hoffmann, Reece M, van Elst, Wendy, Strating, Jeroen RPM, Jenkins, Meredith L, Stariha, Jordan TB, Powell, Cameron J, Boulanger, Martin J, Balla, Tamas, van Kuppeveld, Frank JM, Burke, John E

“…The lipid kinase PI4KB, which generates phosphatidylinositol 4‐phosphate (PI4P), is a key enzyme in regulating membrane transport and is also hijacked by…”
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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs by Rathinaswamy, Manoj K., Jenkins, Meredith L., Duewell, Benjamin R., Zhang, Xuxiao, Harris, Noah J., Evans, John T., Stariha, Jordan T.B., Dalwadi, Udit, Fleming, Kaelin D., Ranga-Prasad, Harish, Yip, Calvin K., Williams, Roger L., Hansen, Scott D., Burke, John E.

“…Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are…”
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Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain by Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew A H, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheeky, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E

“…PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ…”
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Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes by Siraliev-Perez, Edhriz, Stariha, Jordan T B, Hoffmann, Reece M, Temple, Brenda R S, Zhang, Qisheng, Hajicek, Nicole, Jenkins, Meredith L, Burke, John E, Sondek, John

“…Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes at membranes to control diverse cellular processes…”
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An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery by Masson, Glenn R, Jenkins, Meredith L, Burke, John E

“…Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful methodology to study protein dynamics, protein folding, protein-protein interactions, and…”
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Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1 by Dornan, Gillian L., Siempelkamp, Braden D., Jenkins, Meredith L., Vadas, Oscar, Lucas, Carrie L., Burke, John E.

“…Activated PI3K Delta Syndrome (APDS) is a primary immunodeficiency disease caused by activating mutations in either the leukocyte-restricted p110δ catalytic…”
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Escherichia coli and Sf9 Contaminant Databases to Increase Efficiency of Tandem Mass Spectrometry Peptide Identification in Structural Mass Spectrometry Experiments by Dobbs, Joseph M, Jenkins, Meredith L, Burke, John E

“…Filtering of nonspecifically binding contaminant proteins from affinity purification mass spectrometry (AP-MS) data is a well-established strategy to improve…”
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Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas by Siempelkamp, Braden D., Rathinaswamy, Manoj K., Jenkins, Meredith L., Burke, John E.

“…Class IA PI3Ks are involved in the generation of the key lipid signaling molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3), and inappropriate activation…”
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Investigating how intrinsically disordered regions contribute to protein function using HDX-MS by Parson, Matthew A H, Jenkins, Meredith L, Burke, John E

“…A large amount of the human proteome is composed of highly dynamic regions that do not adopt a single static conformation. These regions are defined as…”
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Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition by Fisher, Isaac J., Jenkins, Meredith L., Tall, Gregory G., Burke, John E., Smrcka, Alan V.

“…Phospholipase C (PLC) enzymes hydrolyze phosphoinositide lipids to inositol phosphates and diacylglycerol. Direct activation of PLCβ by Gαq and/or Gβγ subunits…”
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ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1 by Shaw, Alexandria L., Parson, Matthew A.H., Truebestein, Linda, Jenkins, Meredith L., Leonard, Thomas A., Burke, John E.

“…Akt is a master regulator of pro-growth signaling in the cell. Akt is activated by phosphoinositides that disrupt the autoinhibitory interface between the…”
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Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans by Takeda, Andrew J., Zhang, Yu, Dornan, Gillian L., Siempelkamp, Braden D., Jenkins, Meredith L., Matthews, Helen F., McElwee, Joshua J., Bi, Weimin, Seeborg, Filiz O., Su, Helen C., Burke, John E., Lucas, Carrie L.

“…Supporting an intramolecular activation mechanism, we found no difference in association of ectopically expressed WT, E81K, or G124D p110δ with endogenous p85α…”
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