Search Results - "Jenkins, Larry"

Starving Neurons Show Sex Difference in Autophagy by Du, Lina, Hickey, Robert W., Bayir, Hülya, Watkins, Simon C., Tyurin, Vladimir A., Guo, Fengli, Kochanek, Patrick M., Jenkins, Larry W., Ren, Jin, Gibson, Greg, Chu, Charleen T., Kagan, Valerian E., Clark, Robert S.B.

“…Sex-dependent differences in adaptation to famine have long been appreciated, thought to hinge on female versus male preferences for fat versus protein…”
Get full text

Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making by Kochanek, Patrick M, Berger, Rachel P, Bayir, Hülya, Wagner, Amy K, Jenkins, Larry W, Clark, Robert S B

“…Emerging data suggest that biomarkers of brain injury have potential utility as diagnostic, prognostic, and therapeutic adjuncts in the setting of traumatic…”
Get full text

Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury by Garman, Robert H, Jenkins, Larry W, Switzer, 3rd, Robert C, Bauman, Richard A, Tong, Lawrence C, Swauger, Peter V, Parks, Steven A, Ritzel, David V, Dixon, C Edward, Clark, Robert S B, Bayir, Hülya, Kagan, Valerian, Jackson, Edwin K, Kochanek, Patrick M

“…Blast-induced traumatic brain injury (TBI) is the signature insult in combat casualty care. Survival with neurological damage from otherwise lethal blast…”
Get more information

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury by Zhang, Xiaopeng, Chen, Yaming, Jenkins, Larry W, Kochanek, Patrick M, Clark, Robert S B

“…Apoptosis, or programmed cell death, is a physiological form of cell death that is important for normal embryologic development and cell turnover in adult…”
Get full text

Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats by Kochanek, Patrick M, Dixon, C Edward, Shellington, David K, Shin, Samuel S, Bayır, Hülya, Jackson, Edwin K, Kagan, Valerian E, Yan, Hong Q, Swauger, Peter V, Parks, Steven A, Ritzel, David V, Bauman, Richard, Clark, Robert S B, Garman, Robert H, Bandak, Faris, Ling, Geoffrey, Jenkins, Larry W

“…Abstract Explosive blast-induced traumatic brain injury (TBI) is the signature insult in modern combat casualty care and has been linked to post-traumatic…”
Get more information

Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice by Haselkorn, M Lee, Shellington, David K, Jackson, Edwin K, Vagni, Vincent A, Janesko-Feldman, Keri, Dubey, Raghvendra K, Gillespie, Delbert G, Cheng, Dongmei, Bell, Michael J, Jenkins, Larry W, Homanics, Gregg E, Schnermann, Jurgen, Kochanek, Patrick M

“…We reported that adenosine A(1) receptor (A(1)AR) knockout (KO) mice develop lethal status epilepticus after experimental traumatic brain injury (TBI), which…”
Get more information

Autophagy is Increased after Traumatic Brain Injury in Mice and is Partially Inhibited by the Antioxidant γ-glutamylcysteinyl Ethyl Ester by Lai, Yichen, Hickey, Robert W, Chen, Yaming, Bayιr, Hülya, Sullivan, Mara L, Chu, Charleen T, Kochanek, Patrick M, Dixon, C Edward, Jenkins, Larry W, Graham, Steven H, Watkins, Simon C, Clark, Robert SB

“…Autophagy is a homeostatic process for recycling of proteins and organelles, induced by nutrient deprivation and regulated by oxygen radicals. Whether…”
Get full text

Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury by Lai, Yichen, Chen, Yaming, Watkins, Simon C, Nathaniel, Paula D, Guo, Fengli, Kochanek, Patrick M, Jenkins, Larry W, Szabó, Csaba, Clark, Robert S.B

“…Poly-ADP-ribosylation is a post-translational modification performed by poly(ADP-ribose) polymerases (PARP), involved in many diverse cellular functions…”
Get full text

Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury by Kochanek, Patrick M, Vagni, Vincent A, Janesko, Keri L, Washington, Christopher B, Crumrine, Patricia K, Garman, Robert H, Jenkins, Larry W, Clark, Robert SB, Homanics, Gregg E, Dixon, C Edward, Schnermann, Jurgen, Jackson, Edwin K

“…Adenosine, acting at A1 receptors, exhibits anticonvulsant effects in experimental epilepsy—and inhibits progression to status epilepticus (SE). Seizures after…”
Get full text

Mri Assessment of Cerebral Blood Flow after Experimental Traumatic Brain Injury Combined with Hemorrhagic Shock in Mice by Foley, Lesley M, O'Meara, Alia M Iqbal, Wisniewski, Stephen R, Hitchens, T Kevin, Melick, John A, Ho, Chien, Jenkins, Larry W, Kochanek, Patrick M

“…Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after traumatic brain injury (TBI). We recently developed a mouse…”
Get full text

Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice by Hemerka, Joseph N, Wu, Xianren, Dixon, C Edward, Garman, Robert H, Exo, Jennifer L, Shellington, David K, Blasiole, Brian, Vagni, Vincent A, Janesko-Feldman, Keri, Xu, Mu, Wisniewski, Stephen R, Bayır, Hülya, Jenkins, Larry W, Clark, Robert S B, Tisherman, Samuel A, Kochanek, Patrick M

“…Hypotension after traumatic brain injury (TBI) worsens outcome. We published the first report of TBI plus hemorrhagic shock (HS) in mice using a…”
Get more information

Polynitroxylated pegylated hemoglobin: A novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice by Shellington, David K, Du, Lina, Wu, Xianren, Exo, Jennifer, Vagni, Vincent, Ma, Li, Janesko-Feldman, Keri, Clark, Robert S.B, Bayir, Hülya, Dixon, C. Edward, Jenkins, Larry W, Hsia, Carleton J.C, Kochanek, Patrick M

“…OBJECTIVE:Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The…”
Get full text

Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats by Statler, Kimberly D, Alexander, Henry, Vagni, Vincent, Dixon, C Edward, Clark, Robert S B, Jenkins, Larry, Kochanek, Patrick M

“…Isoflurane is commonly used in experimental traumatic brain injury (TBI), both before and early after injury, yet it is rarely used clinically. Narcotics and…”
Get more information

Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death by Dennis, Alia Marie, Haselkorn, M Lee, Vagni, Vincent A, Garman, Robert H, Janesko-Feldman, Keri, Bayir, Hülya, Clark, Robert S B, Jenkins, Larry W, Dixon, C Edward, Kochanek, Patrick M

“…Traumatic brain injury (TBI) from blast injury is often complicated by hemorrhagic shock (HS) in victims of terrorist attacks. Most studies of HS after…”
Get more information

Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice by Clark, Robert S B, Vagni, Vincent A, Nathaniel, Paula D, Jenkins, Larry W, Dixon, C Edward, Szabó, Csaba

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme best known for its role in DNA repair and as a mediator of NAD+ depletion and energy failure-induced cell…”
Get more information

Expression of protein phosphatase 2B (calcineurin) subunit A isoforms in rat hippocampus after traumatic brain injury by Bales, James W, Ma, Xiecheng, Yan, Hong Q, Jenkins, Larry W, Dixon, C Edward

“…Calcineurin (CaN) is a calcium/calmodulin-dependent phosphatase directly activated by calcium as a result of neuronal activation that is important for neuronal…”
Get more information

Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and neuronal death in mice by Exo, Jennifer L, Shellington, David K, Bayir, Hülya, Vagni, Vincent A, Janesco-Feldman, Keri, Ma, Lil, Hsia, Carleton J, Clark, Robert S B, Jenkins, Larry W, Dixon, C Edward, Kochanek, Patrick M

“…Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal resuscitation approach is unclear. In particular, treatment…”
Get more information

Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury by Bales, James W, Ma, Xiecheng, Yan, Hong Q, Jenkins, Larry W, Dixon, C. Edward

“…Abstract Calcineurin subunit isoforms are implicated in long term potentiation, long term depression, and structural plasticity. Calcineurin inhibitors benefit…”
Get full text

Immunohistochemical analysis of histone H3 acetylation and methylation—Evidence for altered epigenetic signaling following traumatic brain injury in immature rats by Gao, Wei-Min, Chadha, Mandeep S., Kline, Anthony E., Clark, Robert S.B., Kochanek, Patrick M., Dixon, C. Edward, Jenkins, Larry W.

“…Posttranslational modifications (PTMs) of histone proteins may result in altered epigenetic signaling after pediatric traumatic brain injury (TBI). Hippocampal…”
Get full text

A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury by Gao, Wei-Min, Chadha, Mandeep S, Berger, Rachel P, Omenn, Gilbert S, Allen, David L, Pisano, Michael, Adelson, P David, Clark, Robert S B, Jenkins, Larry W, Kochanek, Patrick M

“…Traumatic brain injury (TBI) is the most common cause of traumatic death in infancy, and inflicted TBI (iTBI) is the predominant cause. Like other central…”
Get more information