Search Results - "Jenkins, Gareth J.S."

NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials by Singh, Neenu, Manshian, Bella, Jenkins, Gareth J.S, Griffiths, Sioned M, Williams, Paul M, Maffeis, Thierry G.G, Wright, Chris J, Doak, Shareen H

“…Abstract With the rapid expansion in the nanotechnology industry, it is essential that the safety of engineered nanomaterials and the factors that influence…”
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The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles by Singh, Neenu, Jenkins, Gareth J.S, Nelson, Bryant C, Marquis, Bryce J, Maffeis, Thierry G.G, Brown, Andy P, Williams, Paul M, Wright, Chris J, Doak, Shareen H

“…Abstract Ultrafine superparamagnetic iron oxide nanoparticles (USPION) hold great potential for revolutionising biomedical applications such as MRI, localised…”
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Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens by DOAK, Shareen H, JENKINS, Gareth J. S, JOHNSON, George E, QUICK, Emma, PARRY, Elizabeth M, PARRY, James M

“…A mechanistic understanding of carcinogenic genotoxicity is necessary to determine consequences of chemical exposure on human populations and improve health…”
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Genotoxic thresholds, DNA repair, and susceptibility in human populations by Jenkins, Gareth J.S, Zaïr, Zoulikha, Johnson, George E, Doak, Shareen H

“…Abstract It has been long assumed that DNA damage is induced in a linear manner with respect to the dose of a direct acting genotoxin. Thus, it is implied that…”
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Opportunities and Challenges for Integrating New In Vitro Methodologies in Hazard Testing and Risk Assessment by Burden, Natalie, Clift, Martin J. D., Jenkins, Gareth J. S., Labram, Briony, Sewell, Fiona

“…Nanomaterials are defined as materials with at least one dimension of 100 nm or less. Their small size confers unique properties that may alter the toxicity…”
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An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health by Clift, Martin J. D., Jenkins, Gareth J. S., Doak, Shareen H.

“…To elucidate the impact of human exposure to engineered nanomaterials, advanced in vitro models are a valid non‐animal alternative. Despite significant gains…”
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In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment by Llewellyn, Samantha V., Niemeijer, Marije, Nymark, Penny, Moné, Martijn J., Water, Bob, Conway, Gillian E., Jenkins, Gareth J. S., Doak, Shareen H.

“…Whilst the liver possesses the ability to repair and restore sections of damaged tissue following acute injury, prolonged exposure to engineered nanomaterials…”
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Identification of Early p53 Mutations in Clam Ileocystoplasties Using Restriction Site Mutation Assay by Ivil, Kenneth D, Jenkins, Spencer A, Doak, Shareen H, Hawizy, Azad M, Kynaston, Howard G, Parry, Elizabeth M, Jenkins, Gareth J.S, Parry, James M, Stephenson, Timothy P

“…Objectives Because a risk of cancer arising in enterocystoplasties exists, it is necessary to identify which patients are most at risk of tumor formation. The…”
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Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: the potential role of anti-oxidants in Barrett's oesophagus by Jenkins, Gareth J.S., D'Souza, Francis R., Suzen, Sinan H., Eltahir, Zak S., James, Sally A., Parry, James M., Griffiths, Paul A., Baxter, John N.

“…Bile acids are often refluxed into the lower oesophagus and are candidate carcinogens in the development of oesophageal adenocarcinoma. We show here that the…”
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Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer by Williamson, Jeremy S, Harris, Dean A, Beynon, John, Jenkins, Gareth J S

“…There is much debate around the preoperative treatment of colorectal cancer and, in particular, neoadjuvant chemoradiotherapy in locally advanced rectal…”
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Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) by Singh, Neenu, Jenkins, Gareth J.S., Asadi, Romisa, Doak, Shareen H.

“…Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various biomedical applications, for example, magnetic resonance imaging, targeted…”
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PCR-based methodology for the determination of the photoprotection afforded by sunscreen application by Jenkins, G J, Parry, J M

“…We have applied a PCR-based methodology to study the DNA damage induced by UV-A, UV-B and sunlight itself. Our results, employing a cell-free system, indicate…”
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A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies by Shah, Ume-Kulsoom, Mallia, Jefferson de Oliveira, Singh, Neenu, Chapman, Katherine E., Doak, Shareen H., Jenkins, Gareth J.S.

“…•Hanging-drop HepG2 spheroids were applied to the in vitro genotoxicity testing of exogenous agents for first time.•3D hanging spheroids are more metabolically…”
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Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety by Cronin, James G, Jones, Nicholas, Thornton, Catherine A, Jenkins, Gareth J. S, Doak, Shareen H, Clift, Martin J. D

“…Human exposure to engineered nanomaterials (ENMs) is inevitable due to the plethora of applications for which they are being manufactured and integrated…”
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An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens by Chapman, Katherine E, Shah, Ume-Kulsoom, Fletcher, Jessica F, Johnson, George E, Doak, Shareen H, Jenkins, Gareth J S

“…Chemical safety testing plays a crucial role in product and pharmacological development, as well as chemoprevention; however, in vitro genotoxicity safety…”
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Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints by Manshian, Bella B, Soenen, Stefaan J, Al-Ali, Abdullah, Brown, Andy, Hondow, Nicole, Wills, John, Jenkins, Gareth J S, Doak, Shareen H

“…Toxicity of nanoparticles (NPs) is often correlated with the physicochemical characteristics of the materials. However, some discrepancies are noted in…”
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Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity by Evans, Stephen J, Clift, Martin J D, Singh, Neenu, de Oliveira Mallia, Jefferson, Burgum, Michael, Wills, John W, Wilkinson, Thomas S, Jenkins, Gareth J S, Doak, Shareen H

“…With the need to understand the potential biological impact of the plethora of nanoparticles (NPs) being manufactured for a wide range of potential human…”
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Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids by Llewellyn, Samantha V., Kermanizadeh, Ali, Ude, Victor, Jacobsen, Nicklas Raun, Conway, Gillian E., Shah, Ume-Kulsoom, Niemeijer, Marije, Moné, Martijn J., van de Water, Bob, Roy, Shambhu, Moritz, Wolfgang, Stone, Vicki, Jenkins, Gareth J.S., Doak, Shareen H.

“…To reduce, replace, and refine in vivo testing, there is increasing emphasis on the development of more physiologically relevant in vitro test systems to…”
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Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™) by Wills, John W, Hondow, Nicole, Thomas, Adam D, Chapman, Katherine E, Fish, David, Maffeis, Thierry G, Penny, Mark W, Brown, Richard A, Jenkins, Gareth J S, Brown, Andy P, White, Paul A, Doak, Shareen H

“…The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and…”
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Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies by Shah, Ume-Kulsoom, Mallia, Jefferson de Oliveira, Singh, Neenu, Chapman, Katherine E., Doak, Shareen H., Jenkins, Gareth J.S.

“…•Hanging-drop HepG2 spheroids were applied to the in vitro genotoxicity testing of exogenous agents for first time.•3D hanging spheroids are more metabolically…”
Get full text