Search Results - "Jenkins, Bruce"

Pharmacologic magnetic resonance imaging (phMRI): Imaging drug action in the brain by Jenkins, Bruce G.

“…The technique of functional magnetic resonance (fMRI), using various cognitive, motor and sensory stimuli has led to a revolution in the ability to map brain…”
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Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease by Kantarci, Alpdogan, Aytan, Nurgul, Palaska, Iro, Stephens, Danielle, Crabtree, Leah, Benincasa, Claudia, Jenkins, Bruce G., Carreras, Isabel, Dedeoglu, Alpaslan

“…Dysfunction in the resolution of inflammation may play a key role in Alzheimer's disease (AD). In this study, we found that the levels of specialized…”
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Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease by Aytan, Nurgul, Choi, Ji-Kyung, Carreras, Isabel, Brinkmann, Volker, Kowall, Neil W., Jenkins, Bruce G., Dedeoglu, Alpaslan

“…Sphingosine 1-phosphate (SP1) receptors may be attractive targets for modulation of inflammatory processes in neurodegenerative diseases. Recently fingolimod,…”
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Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease by Aytan, Nurgul, Choi, Ji-Kyung, Carreras, Isabel, Crabtree, Leah, Nguyen, Brian, Lehar, Margaret, Blusztajn, Jan Krzysztof, Jenkins, Bruce G., Dedeoglu, Alpaslan

“…Interest in brain-derived neurotrophic factor (BDNF) was greatly enhanced when it was recognized that its expression is reduced in neurodegenerative disorders,…”
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Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer’s disease by Carreras, Isabel, Aytan, Nurgul, Choi, Ji-Kyung, Tognoni, Christina M., Kowall, Neil W., Jenkins, Bruce G., Dedeoglu, Alpaslan

“…Lipid metabolism is abnormal in Alzheimer’s disease (AD) brain leading to ceramide and sphingosine accumulation and reduced levels of brain…”
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7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis by Korkmaz, Orhan Tansel, Aytan, Nurgul, Carreras, Isabel, Choi, Ji-Kyung, Kowall, Neil W., Jenkins, Bruce G., Dedeoglu, Alpaslan

“…•We tested the effect of 7,8-DHF on lower motor neurons in ALS mice.•Chronic administration of 7,8-DHF improved motor deficits in ALS mice.•7,8-DHF preserved…”
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The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation by Mealer, Robert G., Jenkins, Bruce G., Chen, Chia-Yen, Daly, Mark J., Ge, Tian, Lehoux, Sylvain, Marquardt, Thorsten, Palmer, Christopher D., Park, Julien H., Parsons, Patrick J., Sackstein, Robert, Williams, Sarah E., Cummings, Richard D., Scolnick, Edward M., Smoller, Jordan W.

“…A common missense variant in SLC39A8 is convincingly associated with schizophrenia and several additional phenotypes. Homozygous loss-of-function mutations in…”
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Acute administration of ketone beta-hydroxybutyrate downregulates 7T proton magnetic resonance spectroscopy-derived levels of anterior and posterior cingulate GABA and glutamate in healthy adults by Hone-Blanchet, Antoine, Antal, Botond, McMahon, Liam, Lithen, Andrew, Smith, Nathan A, Stufflebeam, Steven, Yen, Yi-Fen, Lin, Alexander, Jenkins, Bruce G, Mujica-Parodi, Lilianne R, Ratai, Eva-Maria

“…Glucose metabolism is impaired in brain aging and several neurological conditions. Beneficial effects of ketones have been reported in the context of…”
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Combination therapy in a transgenic model of Alzheimer's disease by Aytan, Nurgul, Choi, Ji-Kyung, Carreras, Isabel, Kowall, Neil W., Jenkins, Bruce G., Dedeoglu, Alpaslan

“…The pathological accumulation of the β-amyloid protein (Aβ) has been closely associated with synaptic loss and neurotoxicity contributing to cognitive…”
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Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease by Carreras, Isabel, Aytan, Nurgul, Mellott, Tiffany, Choi, Ji-Kyung, Lehar, Margaret, Crabtree, Leah, Leite-Morris, Kimberly, Jenkins, Bruce G., Blusztajn, Jan Krzysztof, Dedeoglu, Alpaslan

“…•Anxiety, Iba1, NGF, NAA, GABA, and GAD67 are early markers of GWI in a mouse model.•Sexual dimorphism was found in mice exposed to GW-related cholinesterase…”
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Revision of the genus Pugillaria Iredale, 1924 (Mollusca: Panpulmonata: Siphonariidae) by Jenkins, Bruce W.

“…The species of Pugillaria Iredale, 1924 are revised and redescribed. Having not been described adequately, the type species Siphonaria stowae Verco, 1906 of…”
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A receptor-based model for dopamine-induced fMRI signal by Mandeville, Joseph B., Sander, Christin Y.M., Jenkins, Bruce G., Hooker, Jacob M., Catana, Ciprian, Vanduffel, Wim, Alpert, Nathaniel M., Rosen, Bruce R., Normandin, Marc D.

“…This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in…”
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Abstinence to chronic methamphetamine switches connectivity between striatal, hippocampal and sensorimotor regions and increases cerebral blood volume response by Choi, Ji-Kyung, Lim, Grewo, Chen, Yin-Ching Iris, Jenkins, Bruce G.

“…Methamphetamine (meth), and other psychostimulants such as cocaine, present a persistent problem for society with chronic users being highly prone to relapse…”
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Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice by McKee, Ann C, Carreras, Isabel, Hossain, Lokman, Ryu, Hoon, Klein, William L, Oddo, Salvatore, LaFerla, Frank M, Jenkins, Bruce G, Kowall, Neil W, Dedeoglu, Alpaslan

“…Abstract We examined the effects of ibuprofen on cognitive deficits, Aβ and tau accumulation in young triple transgenic (3xTg-AD) mice. 3xTg-AD mice were fed…”
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Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling by Choi, Ji-Kyung, Chen, Y. Iris, Hamel, Edith, Jenkins, Bruce G.

“…The coupling between neurotransmitter-induced changes in neuronal activity and the resultant hemodynamic response is central to the interpretation of…”
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R-flurbiprofen improves tau, but not Aϐ pathology in a triple transgenic model of Alzheimer's disease by CARRERAS, Isabel, MCKEE, Ann C, CHOI, Ji-Kyung, AYTAN, Nurgul, KOWALL, Neil W, JENKINS, Bruce G, DEDEOGLU, Alpaslan

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Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration by Jenkins, Bruce G., Zhu, Aijun, Poutiainen, Pekka, Choi, Ji-Kyung, Kil, Kun-Eek, Zhang, Zhaoda, Kuruppu, Darshini, Aytan, Nurgul, Dedeoglu, Alpaslan, Brownell, Anna-Liisa

“…G-protein coupled dopamine and metabotropic glutamate receptors (mGlu) can modulate neurotransmission during Parkinson's disease (PD)-like neurodegeneration…”
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Embryonic Stem Cells Develop into Functional Dopaminergic Neurons after Transplantation in a Parkinson Rat Model by Björklund, Lars M., Sánchez-Pernaute, Rosario, Chung, Sangmi, Andersson, Therese, Iris Yin Ching Chen, Kevin St. P. Mc Naught, Brownell, Anna-Liisa, Jenkins, Bruce G., Wahlestedt, Claes, Kim, Kwang-Soo, Isacson, Ole

“…Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients, current methods are rudimentary, and a reliable donor cell source is…”
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Moderate exercise delays the motor performance decline in a transgenic model of ALS by Carreras, Isabel, Yuruker, Sinan, Aytan, Nurgul, Hossain, Lokman, Choi, Ji-Kyung, Jenkins, Bruce G, Kowall, Neil W, Dedeoglu, Alpaslan

“…Abstract The relationship between exercise and amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by motor neuron loss, rapidly…”
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The effects of aging, housing and ibuprofen treatment on brain neurochemistry in a triple transgene Alzheimer’s disease mouse model using magnetic resonance spectroscopy and imaging by Choi, Ji-Kyung, Carreras, Isabel, Aytan, Nur, Jenkins-Sahlin, Eric, Dedeoglu, Alpaslan, Jenkins, Bruce G

“…Abstract We investigated a triple transgene Alzheimer’s disease (AD) mouse model that recapitulates many of the neurochemical, anatomic, pathologic and…”
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