Search Results - "Jenkins, Brendan J."

The protease ADAM17 at the crossroads of disease: revisiting its significance in inflammation, cancer, and beyond by Saad, Mohamed I, Jenkins, Brendan J

“…The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the pathophysiology of several diseases. ADAM17 is involved in the…”
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STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation by Tye, Hazel, Kennedy, Catherine L., Najdovska, Meri, McLeod, Louise, McCormack, William, Hughes, Norman, Dev, Anouk, Sievert, William, Ooi, Chia Huey, Ishikawa, Tomo-o, Oshima, Hiroko, Bhathal, Prithi S., Parker, Andrew E., Oshima, Masanobu, Tan, Patrick, Jenkins, Brendan J.

“…Gastric cancer (GC) is associated with chronic inflammation; however, the molecular mechanisms promoting tumorigenesis remain ill defined. Using a GC mouse…”
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IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis by Brooks, Gavin D, McLeod, Louise, Alhayyani, Sultan, Miller, Alistair, Russell, Prudence A, Ferlin, Walter, Rose-John, Stefan, Ruwanpura, Saleela, Jenkins, Brendan J

“…Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis…”
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Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice by Bozinovski, Steven, Seow, Huei Jiunn, Chan, Sheau Pyng Jamie, Anthony, Desiree, McQualter, Jonathan, Hansen, Michelle, Jenkins, Brendan J, Anderson, Gary P, Vlahos, Ross

“…Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung…”
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Multifaceted Role of IRAK-M in the Promotion of Colon Carcinogenesis via Barrier Dysfunction and STAT3 Oncoprotein Stabilization in Tumors by Jenkins, Brendan J.

“…Dysregulated interactions between the host immune system and gut microbiota can underpin inflammation, leading to colorectal cancer (CRC). In this issue of…”
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IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 by Greenhill, Claire J, Rose-John, Stefan, Lissilaa, Rami, Ferlin, Walter, Ernst, Matthias, Hertzog, Paul J, Mansell, Ashley, Jenkins, Brendan J

“…Innate immune responses triggered by the prototypical inflammatory stimulus LPS are mediated by TLR4 and involve the coordinated production of a multitude of…”
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The Role of Inflammasome-Associated Innate Immune Receptors in Cancer by Dawson, Ruby E., Jenkins, Brendan J.

“…Dysregulated activation of the innate immune system is a critical driver of chronic inflammation that is associated with at least 30% of all cancers. Innate…”
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The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis by Saad, Mohamed I, McLeod, Louise, Yu, Liang, Ebi, Hiromichi, Ruwanpura, Saleela, Sagi, Irit, Rose-John, Stefan, Jenkins, Brendan J

“…Abstract Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine…”
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Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism by Deswaerte, Virginie, Nguyen, Paul, West, Alison, Browning, Alison F, Yu, Liang, Ruwanpura, Saleela M, Balic, Jesse, Livis, Thaleia, Girard, Charlotte, Preaudet, Adele, Oshima, Hiroko, Fung, Ka Yee, Tye, Hazel, Najdovska, Meri, Ernst, Matthias, Oshima, Masanobu, Gabay, Cem, Putoczki, Tracy, Jenkins, Brendan J

“…Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated…”
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Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis by Jones, Gareth W, Bombardieri, Michele, Greenhill, Claire J, McLeod, Louise, Nerviani, Alessandra, Rocher-Ros, Vidalba, Cardus, Anna, Williams, Anwen S, Pitzalis, Costantino, Jenkins, Brendan J, Jones, Simon A

“…Ectopic lymphoid-like structures (ELSs) reminiscent of secondary lymphoid organs often develop at sites of chronic inflammation where they contribute to…”
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IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3 by Fielding, Ceri A, McLoughlin, Rachel M, McLeod, Louise, Colmont, Chantal S, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon A, Topley, Nicholas, Jenkins, Brendan J

“…The successful resolution of inflammation is dependent upon the coordinated transition from the initial recruitment of neutrophils to a more sustained…”
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Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice by Han, Tae-Su, Voon, Dominic Chih-Cheng, Oshima, Hiroko, Nakayama, Mizuho, Echizen, Kanae, Sakai, Eri, Yong, Zachary Wei Ern, Murakami, Kazuhiro, Yu, Liang, Minamoto, Toshinari, Ock, Chan-Young, Jenkins, Brendan J., Kim, Seong-Jin, Yang, Han-Kwang, Oshima, Masanobu

“…Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation…”
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Tying the knot between cytokine and toll‐like receptor signaling in gastrointestinal tract cancers by Tye, Hazel, Jenkins, Brendan J.

“…Inflammation‐associated malignancies of the gastrointestinal tract (GI), including those of the stomach and colon, collectively rank as the highest cause of…”
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A Method for the Establishment of Human Lung Adenocarcinoma Patient-Derived Xenografts in Mice by Lundy, Joanne, Jenkins, Brendan J, Saad, Mohamed I

“…Patient-derived xenografts (PDXs) are created by implanting human tumor tissue or cells into immunodeficent mice, and enable the study of tumor biology,…”
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Hyperactive gp130/STAT3‐driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development by Hill, David G., Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen, D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J., Jones, Gareth W.

“…Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often develop in tissues affected by…”
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Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity by Balic, Jesse J, Garama, Daniel J, Saad, Mohamed I, Yu, Liang, West, Alison C, West, Alice J, Livis, Thaleia, Bhathal, Prithi S, Gough, Daniel J, Jenkins, Brendan J

“…Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric cancer, has invariably been…”
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ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer by Saad, Mohamed I, Alhayyani, Sultan, McLeod, Louise, Yu, Liang, Alanazi, Mohammad, Deswaerte, Virginie, Tang, Ke, Jarde, Thierry, Smith, Julian A, Prodanovic, Zdenka, Tate, Michelle D, Balic, Jesse J, Watkins, D Neil, Cain, Jason E, Bozinovski, Steven, Algar, Elizabeth, Kohmoto, Tomohiro, Ebi, Hiromichi, Ferlin, Walter, Garbers, Christoph, Ruwanpura, Saleela, Sagi, Irit, Rose‐John, Stefan, Jenkins, Brendan J

“…Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct therapeutic targeting of KRAS has been problematic. Here, we reveal an…”
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Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease by Balic, Jesse J., Saad, Mohamed I., Dawson, Ruby, West, Alice J., McLeod, Louise, West, Alison C., D'Costa, Kimberley, Deswaerte, Virginie, Dev, Anouk, Sievert, William, Gough, Daniel J., Bhathal, Prithi S., Ferrero, Richard L., Jenkins, Brendan J.

“…Gastric cancer is associated with chronic inflammation (gastritis) triggered by persistent Helicobacter pylori (H. pylori) infection. Elevated tyrosine…”
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Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis by Deswaerte, Virginie, Ruwanpura, Saleela M., Jenkins, Brendan J.

“…•Pleiotropic ALR- and NLR-associated inflammasomes modulate numerous cellular processes.•Inflammasomes promote chronic autoinflammatory, autoimmune and…”
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Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer by Jones, Simon A., Jenkins, Brendan J.

“…The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF),…”
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