Search Results - "Jen, Freda E.‐C."

Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions by Day, Christopher J, Bailly, Benjamin, Guillon, Patrice, Dirr, Larissa, Jen, Freda E-C, Spillings, Belinda L, Mak, Johnson, von Itzstein, Mark, Haselhorst, Thomas, Jennings, Michael P

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2…”
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The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria by Zhang, Yuan, Jen, Freda E.-C., Fox, Kate L., Edwards, Jennifer L., Jennings, Michael P.

“…Phosphorylcholine (ChoP) is found in a variety of prokaryotic and eukaryotic organisms. It is now recognized as a critical modification of the surface…”
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The phospholipase A of Neisseria gonorrhoeae lyses eukaryotic membranes and is necessary for survival in neutrophils and cervical epithelial cells by Apicella, Michael A, Edwards, Jennifer L, Ketterer, Margaret R, Weiss, David S, Zhang, Yuan, Jen, Freda E-C, Jennings, Michael P

“…Contact-dependent hemolysins are virulence factors in a number of human pathogens, including entero-invasive and . Here we demonstrate that produces an outer…”
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Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells by Jennings, Michael P., Jen, Freda E.‐C., Roddam, Louise F., Apicella, Michael A., Edwards, Jennifer L.

“…Summary Expression of type IV pili by Neisseria gonorrhoeae plays a critical role in mediating adherence to human epithelial cells. Gonococcal pilin is…”
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Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria by Seib, Kate L., Jen, Freda E.-C., Scott, Adeana L., Tan, Aimee, Jennings, Michael P.

“…Abstract The pathogenic Neisseria provide textbook examples of phase variation: the high frequency, random and reversible switching of gene expression…”
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The dCache Chemoreceptor TlpA of Helicobacter pylori Binds Multiple Attractant and Antagonistic Ligands via Distinct Sites by Johnson, Kevin S, Elgamoudi, Bassam A, Jen, Freda E-C, Day, Christopher J, Sweeney, Emily Goers, Pryce, Megan L, Guillemin, Karen, Haselhorst, Thomas, Korolik, Victoria, Ottemann, Karen M

“…The Helicobacter pylori chemoreceptor TlpA plays a role in dampening host inflammation during chronic stomach colonization. TlpA has a periplasmic dCache_1…”
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Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis by JEN, Freda E.-C, SEIB, Kate L, JENNINGS, Michael P

“…Phase variation is a common feature of host-adapted bacterial pathogens such as Neisseria meningitidis. Recently, we reported that this rapid on/off switching…”
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Glycointeractome of Neisseria gonorrhoeae: Identification of Host Glycans Targeted by the Gonococcus To Facilitate Adherence to Cervical and Urethral Epithelial Cells by Semchenko, Evgeny A, Everest-Dass, Arun V, Jen, Freda E-C, Mubaiwa, Tsitsi D, Day, Christopher J, Seib, Kate L

“…is a significant threat to global health for which a vaccine and novel treatment options are urgently needed. Glycans expressed by human cells are commonly…”
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Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae by Brockman, Kenneth L, Azzari, Patrick N, Branstool, M Taylor, Atack, John M, Schulz, Benjamin L, Jen, Freda E-C, Jennings, Michael P, Bakaletz, Lauren O

“…Biofilms play a critical role in the colonization, persistence, and pathogenesis of many human pathogens. Multiple mucosa-associated pathogens have evolved a…”
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Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cells by Jen, Freda E-C, Warren, Matthew J, Schulz, Benjamin L, Power, Peter M, Swords, W Edward, Weiser, Jeffery N, Apicella, Michael A, Edwards, Jennifer L, Jennings, Michael P

“…Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, auto-aggregation, and DNA transformation. Pili of N…”
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Refinement of immunizing antigens to produce functional blocking antibodies against the AniA nitrite reductase of Neisseria gonorrhoeae by Shewell, Lucy K, Jen, Freda E-C, Jennings, Michael P

“…The emergence of multi-drug resistant Neisseria gonorrhoeae has generated an urgent need for novel therapies or a vaccine to prevent gonococcal disease. In…”
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The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate by Jen, Freda E-C, Semchenko, Evgeny A, Day, Christopher J, Seib, Kate L, Jennings, Michael P

“…Control of the sexually transmitted infection gonorrhea is a major public health challenge, due to the recent emergence of multidrug resistant strains of , and…”
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Neisseria meningitidis Lacking the Major Porins PorA and PorB Is Viable and Modulates Apoptosis and the Oxidative Burst of Neutrophils by Peak, Ian R, Chen, Adrienne, Jen, Freda E.-C, Jennings, Courtney, Schulz, Benjamin L, Saunders, Nigel J, Khan, Arshad, Seifert, H. Steven, Jennings, Michael P

“…The bacterial pathogen Neisseria meningitidis expresses two major outer-membrane porins. PorA expression is subject to phase-variation (high frequency, random,…”
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The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea by Jen, Freda E-C, Ketterer, Margaret R, Semchenko, Evgeny A, Day, Christopher J, Seib, Kate L, Apicella, Michael A, Jennings, Michael P

“…The lipooligosaccharide (LOS) of plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process…”
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Phasevarions in Haemophilus influenzae biogroup aegyptius control expression of multiple proteins by Tram, Greg, Jen, Freda E-C, Phillips, Zachary N, Lancashire, John F, Timms, Jamie, Poole, Jessica, Jennings, Michael P, Atack, John M

“…biogroup is a human-adapted pathogen and the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically…”
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The glycointeractome of serogroup B Neisseria meningitidis strain MC58 by Mubaiwa, Tsitsi D., Hartley-Tassell, Lauren E., Semchenko, Evgeny A., Jen, Freda. E.-C., Srikhanta, Yogitha N., Day, Christopher J., Jennings, Michael P., Seib, Kate L.

“…Neisseria meningitidis express numerous virulence factors that enable it to interact with diverse microenvironments within the host, during both asymptomatic…”
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Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for Phosphorylcholine Modification by Zhang, Yuan, Jen, Freda E-C, Edwards, Jennifer L, Jennings, Michael P

“…Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine (ChoP), which contributes to host mimicry and can also promote…”
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Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility by Peak, Ian R, Jennings, Courtney D, Jen, Freda E-C, Jennings, Michael P

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Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2 by Jen, Freda E.-C, Everest-Dass, Arun V, El-Deeb, Ibrahim M, Singh, Sanjesh, Haselhorst, Thomas, Walker, Mark J, von Itzstein, Mark, Jennings, Michael P

“…Neisseria gonorrhoeae (N. gonorrhoeae) causes the sexually transmitted disease gonorrhea, which has a global incidence of 106 million cases per year. No…”
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New Perspectives on Escherichia coli Signal Peptidase I Substrate Specificity: Investigating Why the TasA Cleavage Site Is Incompatible with LepB Cleavage by Musik, Joanna E, Poole, Jessica, Day, Christopher J, Haselhorst, Thomas, Jen, Freda E-C, Ve, Thomas, Masic, Veronika, Jennings, Michael P, Zalucki, Yaramah M

“…Escherichia coli signal peptidase I (LepB) has been shown to inefficiently cleave secreted proteins with aromatic amino acids at the second position after the…”
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