Search Results - "Jelinsky, Scott A."
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Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
Published in Nature communications (26-03-2021)“…Crohn’s disease (CD) is a chronic transmural inflammation of intestinal segments caused by dysregulated interaction between microbiome and gut immune system…”
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2
IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes
Published in The Journal of biological chemistry (10-11-2017)“…Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity…”
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3
Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis
Published in Rheumatology (Oxford, England) (11-04-2022)“…Abstract Objectives Advances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for Rheumatoid arthritis (RA) patients. Although…”
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4
Myod1 and GR coordinate myofiber-specific transcriptional enhancers
Published in Nucleic acids research (07-05-2021)“…Abstract Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of various cues. Here, we investigated the…”
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Tendon-selective genes identified from rat and human musculoskeletal tissues
Published in Journal of orthopaedic research (01-03-2010)“…Mesenchymal stems cells have a demonstrated ability to differentiate into muscle, bone, and fat. Determining whether these same cells have the ability to…”
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Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs
Published in Scientific reports (21-06-2023)“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic inflammation and is mediated by multiple immune cell types. In this work, we aimed…”
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7
Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells
Published in Proceedings of the National Academy of Sciences - PNAS (17-06-2008)“…Mammalian spermatogenesis is a complex biological process that occurs within a highly organized tissue, the seminiferous epithelium. The coordinated maturation…”
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8
The Rat Epididymal Transcriptome: Comparison of Segmental Gene Expression in the Rat and Mouse Epididymides
Published in Biology of reproduction (01-04-2007)“…Regional differences along the epididymis are essential for the establishment of the luminal environment required for sperm maturation. In the current study,…”
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9
Regulation of gene expression in human tendinopathy
Published in BMC musculoskeletal disorders (03-05-2011)“…Chronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes. These injuries result in a significant amount…”
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10
The Mouse Epididymal Transcriptome: Transcriptional Profiling of Segmental Gene Expression in the Epididymis
Published in Biology of reproduction (01-09-2005)“…Maturation of spermatozoa, including the acquisition of motility and the ability to undergo capacitation, occurs during transit through the dynamic environment…”
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Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction
Published in PLoS genetics (01-05-2014)“…Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk…”
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What Is the Persistence to Methotrexate in Rheumatoid Arthritis, and Does Machine Learning Outperform Hypothesis‐Based Approaches to Its Prediction?
Published in ACR open rheumatology (01-07-2021)“…Objective The objectives of this study were to assess the 1‐year persistence to methotrexate (MTX) initiated as the first ever conventional synthetic…”
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13
Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy
Published in Physiological genomics (01-10-2011)“…Skeletal muscle atrophy can be a consequence of many diseases, environmental insults, inactivity, age, and injury. Atrophy is characterized by active…”
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14
Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway
Published in Cancer research (Chicago, Ill.) (01-08-2009)“…Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the…”
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Molecular signature of methotrexate response among rheumatoid arthritis patients
Published in Frontiers in medicine (2023)“…Methotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but failure of satisfying treatment response occurs in a significant proportion…”
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Differential Gene Expression among the Proximal Segments of the Rat Epididymis Is Lost after Efferent Duct Ligation
Published in Biology of reproduction (01-07-2007)“…The epididymis has traditionally been divided into the caput, corpus, and cauda regions, which are further organized into intraregional segments. In the rat…”
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17
Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
Published in Growth factors (Chur, Switzerland) (01-08-2011)“…Ectopic expression of recombinant human bone morphogenetic protein 2 (rhBMP2) induces osteogenesis, while ectopic expression of rhBMP12 and rhBMP13 induces the…”
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18
Liver X Receptor Is a Therapeutic Target for Photoaging and Chronological Skin Aging
Published in Molecular endocrinology (Baltimore, Md.) (01-11-2008)“…Liver X receptors (LXRα and -β) are liposensors that exert their metabolic effects by orchestrating the expression of macrophage genes involved in lipid…”
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19
Gene Expression During Development of Fetal and Adult Leydig Cells
Published in Annals of the New York Academy of Sciences (01-12-2007)“…: In rats and mice, Leydig cells are formed as two morphologically and functionally different generations. The first generation develops in utero, from…”
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Identification of Rat Cysteine-Rich Secretory Protein 4 (Crisp4) as the Ortholog to Human CRISP1 and Mouse Crisp4
Published in Biology of reproduction (01-05-2006)“…Cysteine-rich secretory proteins (CRISPs) are present in a diverse population of organisms and are defined by 16 conserved cysteine residues spanning a plant…”
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