Search Results - "Jelen, Luke"

Ketamine: A tale of two enantiomers by Jelen, Luke A, Young, Allan H, Stone, James M

“…The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine, an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is…”
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Ketamine for depression by Jelen, Luke A., Stone, James M.

“…Over the last two decades, the dissociative anaesthetic agent ketamine, an uncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist, has emerged as a…”
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The anterior cingulate cortex as a key locus of ketamine’s antidepressant action by Alexander, Laith, Jelen, Luke A., Mehta, Mitul A., Young, Allan H.

“…•Ketamine modulates anterior cingulate cortex (ACC) activity over minutes and hours.•Changes in ACC activity correlate with ketamine’s antidepressant…”
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The opioid system in depression by Jelen, Luke A., Stone, James M., Young, Allan H., Mehta, Mitul A.

“…Opioid receptors are widely distributed throughout the brain and play an essential role in modulating aspects of human mood, reward, and well-being…”
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New antidepressants: New day or false dawn? by Jelen, Luke A., Young, Allan H.

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Psychedelics in the treatment of unipolar mood disorders: a systematic review by Rucker, James JH, Jelen, Luke A, Flynn, Sarah, Frowde, Kyle D, Young, Allan H

“…Unipolar mood disorders, including major depressive disorder and persistent depressive disorder (dysthymia), confer high rates of disability and mortality and…”
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A comparison of MDMA-assisted psychotherapy to non-assisted psychotherapy in treatment-resistant PTSD: A systematic review and meta-analysis by Illingworth, Benjamin JG, Lewis, Declan J, Lambarth, Andrew T, Stocking, Kate, Duffy, James MN, Jelen, Luke A, Rucker, James J

“…Rationale: Novel, evidence-based treatments are required for treatment-resistant post-traumatic stress disorder (PTSD). 3,4-Methylenedioxymethamphetamine…”
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Beyond static measures: A review of functional magnetic resonance spectroscopy and its potential to investigate dynamic glutamatergic abnormalities in schizophrenia by Jelen, Luke A, King, Sinead, Mullins, Paul G, Stone, James M

“…Abnormalities of the glutamate system are increasingly implicated in schizophrenia but their exact nature remains unknown. Proton magnetic resonance…”
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A transdiagnostic systematic review and meta-analysis of ketamine’s anxiolytic effects by Hartland, Hannah, Mahdavi, Kimia, Jelen, Luke A, Strawbridge, Rebecca, Young, Allan H, Alexander, Laith

“…Background: Ketamine may be effective in treating symptoms of anxiety, but the time profile of ketamine’s anxiolytic effect is ill-defined. This systematic…”
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Opioid Mechanisms and the Treatment of Depression by Jelen, Luke A, Young, Allan H, Mehta, Mitul A

“…Opioid receptors are widely expressed in the brain, and the opioid system has a key role in modulating mood, reward processing and stress responsivity. There…”
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RE: Proposed Assisted Dying Bill: implications for mental healthcare and psychiatrists by Jelen, Luke A, de Silva, Upeka, Rucker, James J H, Young, Allan H

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Guidelines for ketamine use in clinical psychiatry practice by Jelen, Luke A, McShane, Rupert, Young, Allan H

“…In this editorial, we emphasise the efficacy and challenges of using ketamine in treatment-resistant depression. We highlight the need for comprehensive…”
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Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis by Livingston, Nicholas R, Kiemes, Amanda, Devenyi, Gabriel A, Knight, Samuel, Lukow, Paulina B, Jelen, Luke A, Reilly, Thomas, Dima, Aikaterini, Nettis, Maria Antonietta, Casetta, Cecilia, Agyekum, Tyler, Zelaya, Fernando, Spencer, Thomas, De Micheli, Andrea, Fusar-Poli, Paolo, Grace, Anthony A, Williams, Steve C R, McGuire, Philip, Egerton, Alice, Chakravarty, M Mallar, Modinos, Gemma

“…Elevated hippocampal perfusion has been observed in people at clinical high risk for psychosis (CHR-P). Preclinical evidence suggests that hippocampal…”
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Historic psychedelic drug trials and the treatment of anxiety disorders by Weston, Neil M., Gibbs, Damian, Bird, Catherine I. V., Daniel, Aster, Jelen, Luke A., Knight, Gemma, Goldsmith, David, Young, Allan H., Rucker, James J.

“…Introduction In this paper, we systematically review literature from 1940 to 2000 relating to the combined use of psychological therapies and psychedelic drugs…”
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Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task by Jelen, Luke A., King, Sinead, Horne, Charlotte M., Lythgoe, David J., Young, Allan H., Stone, James M.

“…The glutamate system is implicated in the pathophysiology of schizophrenia and mood disorders. Using functional magnetic resonance spectroscopy (1H-fMRS), it…”
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Inflammation, Glutamate, and Cognition in Bipolar Disorder Type II: A Proof of Concept Study by King, Sinead, Jelen, Luke A, Horne, Charlotte M, Cleare, Anthony, Pariante, Carmine M, Young, Allan H, Stone, James M

“…Two current theories regarding the neuroscientific bases of mood disorders involve alterations in glutamatergic neurotransmission and excessive activation of…”
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Variants in the zinc transporter-3 encoding gene (SLC30A3) in schizophrenia and bipolar disorder: Effects on brain glutamate-A pilot study by Jelen, Luke A, Green, Mark S, King, Sinead, Morris, Alex G, Zhang, Xinyuan, Lythgoe, David J, Young, Allan H, De Belleroche, Jacqueline, Stone, James M

“…Zinc transporter 3 (ZnT3) has been implicated in the aetiopathology of schizophrenia. In this pilot study, we tested the hypothesis that the presence of a…”
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New Pharmacological Interventions in Bipolar Disorder by Juruena, Mario F, Jelen, Luke A, Young, Allan H, Cleare, Anthony J

“…The biological bases of bipolar disorder include aspects related, among others, to neurohormonal pathways, neurotransmission, signal transduction, regulation…”
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Imaging Brain Glx Dynamics in Response to Pressure Pain Stimulation: A 1H-fMRS Study by Jelen, Luke A., Lythgoe, David J., Jackson, Jade B., Howard, Matthew A., Stone, James M., Egerton, Alice

“…Glutamate signalling is increasingly implicated across a range of psychiatric, neurological and pain disorders. Reliable methodologies are needed to probe the…”
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The Treatment of Bipolar Depression: Current Status and Future Perspectives by Jelen, Luke A., Young, Allan H.

“…Purpose of Review This paper aims to review current available treatment options and to consider future directions in the treatment of bipolar depression…”
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