Search Results - "Jego, Gaëtan"

Targeting heat shock proteins in cancer by Jego, Gaëtan, Hazoumé, Adonis, Seigneuric, Renaud, Garrido, Carmen

“…Abstract Heat shock proteins (HSPs) HSP27, HSP70 and HSP90 are powerful chaperones. Their expression is induced in response to a wide variety of physiological…”
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Biofilms of Lactobacillus plantarum and Lactobacillus fermentum: Effect on stress responses, antagonistic effects on pathogen growth and immunomodulatory properties by Aoudia, Nabil, Rieu, Aurélie, Briandet, Romain, Deschamps, Julien, Chluba, Johanna, Jego, Gaëtan, Garrido, Carmen, Guzzo, Jean

“…Few studies have extensively investigated probiotic functions associated with biofilms. Here, we show that strains of Lactobacillus plantarum and Lactobacillus…”
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Hsp70: A Cancer Target Inside and Outside the Cell by Boudesco, Christophe, Cause, Sebastien, Jego, Gaëtan, Garrido, Carmen

“…Heat shock protein 70 (Hsp70) is the most ubiquitous stress-inducible chaperone. It accumulates in the cells in response to a wide variety of physiological and…”
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First-in-class inhibitor of HSP110 blocks BCR activation through SYK phosphorylation in diffuse large B-cell lymphoma by Gibouin, Vincent Cabaud, Durand, Manon, Boudesco, Christophe, Hermetet, François, Nozickova, Kristyna, Chassagne-Clement, Catherine, Abdelwahed, Mayssa, Klener, Pavel, Garrido, Carmen, Jego, Gaëtan

“…Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is driven by aberrant activation of the B-cell receptor (BCR) and the TLR/MyD88 signaling…”
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The biofilm mode of life boosts the anti‐inflammatory properties of Lactobacillus by Rieu, Aurélie, Aoudia, Nabil, Jego, Gaëtan, Chluba, Johanna, Yousfi, Nadhir, Briandet, Romain, Deschamps, Julien, Gasquet, Benoît, Monedero, Vicente, Garrido, Carmen, Guzzo, Jean

“…Summary The predominant form of life for microorganisms in their natural habitats is the biofilm mode of growth. The adherence and colonization of probiotic…”
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Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer Therapy by Jego, Gaëtan, Hermetet, François, Girodon, François, Garrido, Carmen

“…While cells from multicellular organisms are dependent upon exogenous signals for their survival, growth, and proliferation, commitment to a specific cell fate…”
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A first-in-class inhibitor of HSP110 to potentiate XPO1-targeted therapy in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma by Durand, Manon, Cabaud Gibouin, Vincent, Duplomb, Laurence, Salmi, Leila, Caillot, Mélody, Sola, Brigitte, Camus, Vincent, Jardin, Fabrice, Garrido, Carmen, Jego, Gaëtan

“…Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) are distinct hematological malignancies of B-cell origin that share many…”
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Heat-Shock Proteins in Leukemia and Lymphoma: Multitargets for Innovative Therapeutic Approaches by Cabaud-Gibouin, Vincent, Durand, Manon, Quéré, Ronan, Girodon, François, Garrido, Carmen, Jego, Gaëtan

“…Heat-shock proteins (HSPs) are powerful chaperones that provide support for cellular functions under stress conditions but also for the homeostasis of basic…”
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Toll-like receptors: lessons to learn from normal and malignant human B cells by Chiron, David, Bekeredjian-Ding, Isabelle, Pellat-Deceunynck, Catherine, Bataille, Régis, Jego, Gaëtan

“…The humoral immune system senses microbes via recognition of specific microbial molecular motifs by Toll-like receptors (TLRs). These encounters promote plasma…”
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Neutralization of HSF1 in cells from PIK3CA-related overgrowth spectrum patients blocks abnormal proliferation by Da Costa, Romain, De Almeida, Steven, Chevarin, Martin, Hadj-Rabia, Smail, Leclerc-Mercier, Stéphanie, Thauvin-Robinet, Christel, Garrido, Carmen, Faivre, Laurence, Vabres, Pierre, Duplomb, Laurence, Jego, Gaëtan

“…PIK3CA-related overgrowth spectrum is caused by mosaicism mutations in the PIK3CA gene. These mutations, which are also observed in various types of cancer,…”
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TLR3 Ligand Induces NF-κB Activation and Various Fates of Multiple Myeloma Cells Depending on IFN-α Production by Chiron, David, Pellat-Deceunynck, Catherine, Amiot, Martine, Bataille, Régis, Jego, Gaëtan

“…Multiple myeloma (MM) cells express TLR. It has been shown that TLR ligands induce the proliferation, survival, and immune surveillance escape of MM cells…”
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Cohen syndrome is associated with major glycosylation defects by Duplomb, Laurence, Duvet, Sandrine, Picot, Damien, Jego, Gaëtan, El Chehadeh-Djebbar, Salima, Marle, Nathalie, Gigot, Nadège, Aral, Bernard, Carmignac, Virginie, Thevenon, Julien, Lopez, Estelle, Rivière, Jean-Baptiste, Klein, André, Philippe, Christophe, Droin, Nathalie, Blair, Edward, Girodon, François, Donadieu, Jean, Bellanné-Chantelot, Christine, Delva, Laurent, Michalski, Jean-Claude, Solary, Eric, Faivre, Laurence, Foulquier, François, Thauvin-Robinet, Christel

“…Cohen syndrome (CS) is a rare autosomal recessive disorder with multisytemic clinical features due to mutations in the VPS13B gene, which has recently been…”
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The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapy by Bataille, R, Jego, G, Robillard, N, Barille-Nion, S, Harousseau, JL, Moreau, P, Amiot, M, Pellat-Deceunynck, C

“…INSERM, U601, Nantes, France. The aim of this review is to integrate non-exhaustive relevant data on the phenotype of human plasma cells (PC), including…”
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Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms by De Almeida, Steven, Regimbeau, Mathilde, Jego, Gaëtan, Garrido, Carmen, Girodon, François, Hermetet, François

“…Myeloproliferative neoplasms (MPN) are a group of clonal disorders that affect hematopoietic stem/progenitor cells. These disorders are often caused by…”
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Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia by Duplomb, Laurence, Rivière, Julie, Jego, Gaëtan, Da Costa, Romain, Hammann, Arlette, Racine, Jessica, Schmitt, Alain, Droin, Nathalie, Capron, Claude, Gougerot-Pocidalo, Marie-Anne, Dubrez, Laurence, Aral, Bernard, Lafon, Arnaud, Edery, Patrick, Ghoumid, Jamal, Blair, Edward, El Chehadeh-Djebbar, Salima, Carmignac, Virginie, Thevenon, Julien, Guy, Julien, Girodon, François, Bastie, Jean-Noël, Delva, Laurent, Faivre, Laurence, Thauvin-Robinet, Christel, Solary, Eric

“…Cohen syndrome (CS) is a rare genetic disorder due to mutations in VPS13B gene. Among various clinical and biological features, CS patients suffer from…”
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Phosphorothioate-Modified TLR9 Ligands Protect Cancer Cells against TRAIL-Induced Apoptosis by Chiron, David, Pellat-Deceunynck, Catherine, Maillasson, Mike, Bataille, Regis, Jego, Gaetan

“…Hypomethylated CpG oligodeoxynucleotides (CpG ODNs) target TLR9 expressed by immune cells and are currently being evaluated as adjuvants in clinical trials…”
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Insulin response dysregulation explains abnormal fat storage and increased risk of diabetes mellitus type 2 in Cohen Syndrome by Limoge, Floriane, Faivre, Laurence, Gautier, Thomas, Petit, Jean-Michel, Gautier, Elodie, Masson, David, Jego, Gaëtan, El Chehadeh-Djebbar, Salima, Marle, Nathalie, Carmignac, Virginie, Deckert, Valérie, Brindisi, Marie-Claude, Edery, Patrick, Ghoumid, Jamal, Blair, Edward, Lagrost, Laurent, Thauvin-Robinet, Christel, Duplomb, Laurence

“…Cohen Syndrome (CS) is a rare autosomal recessive disorder, with defective glycosylation secondary to mutations in the VPS13B gene, which encodes a protein of…”
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Interleukin-6 is a growth factor for nonmalignant human plasmablasts by Jego, Gaëtan, Bataille, Régis, Pellat-Deceunynck, Catherine

“…Interleukin-6 (IL-6), although often regarded as a B-cell differentiation factor, was recently described as the essential survival factor for human…”
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XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-Cell Lymphoma by Miloudi, Hadjer, Bohers, Élodie, Guillonneau, François, Taly, Antoine, Gibouin, Vincent Cabaud, Viailly, Pierre-Julien, Jego, Gaëtan, Grumolato, Luca, Jardin, Fabrice, Sola, Brigitte

“…The XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL)…”
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Hsp70: anti-apoptotic and tumorigenic protein by Rérole, Anne-Laure, Jego, Gaëtan, Garrido, Carmen

“…Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression is induced in response to a wide variety of physiological and environmental insults,…”
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