Search Results - "Jeggo, Penelope A"

The Repair and Signaling Responses to DNA Double-Strand Breaks by Goodarzi, Aaron A., Jeggo, Penelope A.

“…A DNA double-strand break (DSB) has long been recognized as a severe cellular lesion, potentially representing an initiating event for carcinogenesis or cell…”
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53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair by Löbrich, Markus, Jeggo, Penelope A, Noon, Angela T, Rief, Nicole, Goodarzi, Aaron A, Shibata, Atsushi, Stewart, Grant S

“…DNA double-strand breaks (DSBs) trigger ATM (ataxia telangiectasia mutated) signalling and elicit genomic rearrangements and chromosomal fragmentation if…”
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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX by Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.

“…53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin…”
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The complexity of DNA double strand breaks is a critical factor enhancing end-resection by Yajima, Hirohiko, Fujisawa, Hiroshi, Nakajima, Nakako Izumi, Hirakawa, Hirokazu, Jeggo, Penelope A., Okayasu, Ryuichi, Fujimori, Akira

“…•Heavy ion beam-induced complex DSBs efficiently activate DNA end resection.•Up to 85% of complex DSBs undergo resection in G2 cells.•Around 20–40% of human G1…”
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Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage by Burkhalter, Martin D., Stiff, Tom, Maerz, Lars D., Casar Tena, Teresa, Wiese, Heike, Gerhards, Julian, Sailer, Steffen A., Vu, Linh Anna Trúc, Duong Phu, Max, Donow, Cornelia, Alupei, Marius, Iben, Sebastian, Groth, Marco, Wiese, Sebastian, Church, Joseph A., Jeggo, Penelope A., Philipp, Melanie

“…The WD repeat-containing protein 4 (WDR4) has repeatedly been associated with primary microcephaly, a condition of impaired brain and skull growth. Often,…”
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Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress by Zimmerman, Kristin M, Jones, Rebecca M, Petermann, Eva, Jeggo, Penelope A

“…Previous studies have shown that dormant licensed replication origins can be exploited to enhance recovery from replication stress. Since tumor cells express…”
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KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response by Goodarzi, Aaron A, Jeggo, Penelope A, Kurka, Thomas

“…Heterochromatin factor KAP-1 is phosphorylated by ATM during the DNA damage response. Now the functional consequences of this modification are explored,…”
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Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome by Nijnik, Anastasia, Dawson, Sara, Crockford, Tanya L, Woodbine, Lisa, Visetnoi, Supawan, Bennett, Sophia, Jones, Margaret, Turner, Gareth D, Jeggo, Penelope A, Goodnow, Christopher C, Cornall, Richard J

“…Hypomorphic mutations in DNA ligase IV (LIG4) cause a human syndrome of immunodeficiency, radiosensitivity, and growth retardation due to defective DNA repair…”
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Distinct response of adult neural stem cells to low versus high dose ionising radiation by Barazzuol, Lara, Hopkins, Suzanna R., Ju, Limei, Jeggo, Penelope A.

“…•Apoptosis arises linearly with the radiation dose in adult neural progenitor cells.•Proliferation arrest and differentiation are inefficiently activated at…”
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DNA repair is limiting for haematopoietic stem cells during ageing by Nijnik, Anastasia, Liu, Cong, Dawson, Sara, Jeggo, Penelope A, Woodbine, Lisa, Lambe, Teresa, Goodnow, Christopher C, Enver, Tariq, Bell, John I, Crockford, Tanya L, Cornall, Richard J, Marchetti, Caterina, Rodrigues, Neil P, Cabuy, Erik, Vindigni, Alessandro, Slijepcevic, Predrag

“…Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of ageing. Here we address this question by…”
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Establishing mechanisms affecting the individual response to ionizing radiation by Averbeck, Dietrich, Candéias, Serge, Chandna, Sudhir, Foray, Nicolas, Friedl, Anna A., Haghdoost, Siamak, Jeggo, Penelope A., Lumniczky, Katalin, Paris, Francois, Quintens, Roel, Sabatier, Laure

“…Purpose: Humans are increasingly exposed to ionizing radiation (IR). Both low (<100 mGy) and high doses can cause stochastic effects, including cancer; whereas…”
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Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response by Lee, Dong-Hyun, Goodarzi, Aaron A, Adelmant, Guillaume O, Pan, Yunfeng, Jeggo, Penelope A, Marto, Jarrod A, Chowdhury, Dipanjan

“…Protein phosphatase PP4C has been implicated in the DNA damage response (DDR), but its substrates in DDR remain largely unknown. We devised a novel proteomic…”
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Resting cells rely on the DNA helicase component MCM2 to build cilia by Casar Tena, Teresa, Maerz, Lars D, Szafranski, Karol, Groth, Marco, Blätte, Tamara J, Donow, Cornelia, Matysik, Sabrina, Walther, Paul, Jeggo, Penelope A, Burkhalter, Martin D, Philipp, Melanie

“…Abstract Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number…”
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Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors by Maerz, Lars D, Casar Tena, Teresa, Gerhards, Julian, Donow, Cornelia, Jeggo, Penelope A, Philipp, Melanie

“…Meier-Gorlin syndrome (MGS) is a rare, congenital primordial microcephalic dwarfism disorder. MGS is caused by genetic variants of components of the origin…”
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The life and death of DNA-PK by COLLIS, Spencer J, DEWEESE, Theodore L, JEGGO, Penelope A, PARKER, Antony R

“…Double-strand breaks (DSBs) arise endogenously during normal cellular processes and exogenously by genotoxic agents such as ionizing radiation (IR). DSBs are…”
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Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity by Marcou, Yiola, D'Andrea, Andrew, Jeggo, Penelope A, Plowman, Piers N

“…Background: Fanconi anaemia is a rare disease associated with cellular sensitivity to chemicals (e.g. mitomycin C and diepoxybutane); variable but mild…”
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Reduced joining of DNA ends correlates with chromosomal instability in three melanoma cell lines by Rünger, Thomas M, Kotas, Markus, Poot, Martin, Leverkus, Martin, Epe, Bernd, Jeggo, Penelope A, Hellfritsch, Doris

“…Chromosomal instability plays a pivotal role in multistep carcinogenesis by facilitating the acquisition of the multiple genetic alterations necessary for…”
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Chapter One - The Repair and Signaling Responses to DNA Double-Strand Breaks by Goodarzi, Aaron A, Jeggo, Penelope A

“…A DNA double-strand break (DSB) has long been recognized as a severe cellular lesion, potentially representing an initiating event for carcinogenesis or cell…”
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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT 2 Domain with γH2AX by Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.

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Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response: PP4 regulates KAP-1 function in DDR by Lee, Dong-Hyun, Goodarzi, Aaron A, Adelmant, Guillaume O, Pan, Yunfeng, Jeggo, Penelope A, Marto, Jarrod A, Chowdhury, Dipanjan

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