Search Results - "Jeffrey E. Lee"

Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex by Aydin, Halil, Sultana, Azmiri, Li, Sheng, Thavalingam, Annoj, Lee, Jeffrey E.

“…This study describes the structures of the IZUMO1 protein, found on sperm, and the JUNO protein, found on eggs, and sheds light on their roles in sperm–egg…”
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The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors by Howe, James R., Merchant, Nipun B., Conrad, Claudius, Keutgen, Xavier M., Hallet, Julie, Drebin, Jeffrey A., Minter, Rebecca M., Lairmore, Terry C., Tseng, Jennifer F., Zeh, Herbert J., Libutti, Steven K., Singh, Gagandeep, Lee, Jeffrey E., Hope, Thomas A., Kim, Michelle K., Menda, Yusuf, Halfdanarson, Thorvardur R., Chan, Jennifer A., Pommier, Rodney F.

“…This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine…”
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The cell biology of fertilization: Gamete attachment and fusion by Siu, Karen K, Serrão, Vitor Hugo B, Ziyyat, Ahmed, Lee, Jeffrey E

“…Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse to form a diploid zygote to initiate prenatal development. In…”
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The secret life of viral entry glycoproteins: moonlighting in immune evasion by Cook, Jonathan D, Lee, Jeffrey E

“…  The dense clustering of glycans creates an unfavorable environment for the interaction of otherwise neutralizing antibodies. [...]critical regions on EBOV…”
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Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α by Tarade, Daniel, Lee, Jeffrey E., Ohh, Michael

“…Duplication of ancestral hypoxia-inducible factor (HIF)α coincided with the evolution of vertebrate species. Paralogs HIF1α and HIF2α are the most well-known…”
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Structure-Guided Analysis of the Human APOBEC3-HIV Restrictome by Aydin, Halil, Taylor, Matthew W., Lee, Jeffrey E.

“…Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the replication of many retroviral pathogens. Restriction is believed…”
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Radiographic and Serologic Predictors of Pathologic Major Response to Preoperative Therapy for Pancreatic Cancer by Perri, Giampaolo, Prakash, Laura, Wang, Huamin, Bhosale, Priya, Varadhachary, Gauri R., Wolff, Robert, Fogelman, David, Overman, Michael, Pant, Shubham, Javle, Milind, Koay, Eugene, Herman, Joseph, Kim, Michael, Ikoma, Naruhiko, Tzeng, Ching-Wei, Lee, Jeffrey E., Katz, Matthew H. G.

“…OBJECTIVE:We sought to identify potential radiologic and serologic markers of pancreatic tumor response to therapy, using pathologic major response (pMR) as…”
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Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody by Hashiguchi, Takao, Fusco, Marnie L., Bornholdt, Zachary A., Lee, Jeffrey E., Flyak, Andrew I., Matsuoka, Rei, Kohda, Daisuke, Yanagi, Yusuke, Hammel, Michal, Crowe, James E., Saphire, Erica Ollmann

“…The filoviruses, including Marburg and Ebola, express a single glycoprotein on their surface, termed GP, which is responsible for attachment and entry of…”
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HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease by Tarade, Daniel, Robinson, Claire M., Lee, Jeffrey E., Ohh, Michael

“…It is definitively established that mutations in transcription factor HIF-2α are causative of both neuroendocrine tumors (class 1 disease) and polycythemia…”
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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor by Saphire, Erica Ollmann, Lee, Jeffrey E, Fusco, Marnie L, Hessell, Ann J, Oswald, Wendelien B, Burton, Dennis R

“…Ebola virus (EBOV) entry requires the surface glycoprotein (GP) to initiate attachment and fusion of viral and host membranes. Here we report the crystal…”
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Ninety-day Postoperative Mortality Is a Legitimate Measure of Hepatopancreatobiliary Surgical Quality by Mise, Yoshihiro, Vauthey, Jean-Nicolas, Zimmitti, Giuseppe, Parker, Nathan H, Conrad, Claudius, Aloia, Thomas A, Lee, Jeffrey E, Fleming, Jason B, Katz, Matthew Harold G

“…OBJECTIVE:To investigate the legitimacy of 90-day mortality as a measure of hepatopancreatobiliary quality. BACKGROUND:The 90-day mortality rate has been…”
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Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F by Siu, Karen K., Sultana, Azmiri, Azimi, Farshad C., Lee, Jeffrey E.

“…The human APOBEC3 family of DNA cytosine deaminases serves as a front-line intrinsic immune response to inhibit the replication of diverse retroviruses…”
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Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients by RADVANYI, Laszlo G, BERNATCHEZ, Chantale, GLASS, Michelle, JOHNSON, Valen E, MCMANNIS, John D, SHPALL, Elizabeth, PRIETO, Victor, PAPADOPOULOS, Nicholas, KIM, Kevin, HOMSI, Jade, BEDIKIAN, Agop, HWU, Wen-Jen, MINYING ZHANG, PATEL, Sapna, ROSS, Merrick I, LEE, Jeffrey E, GERSHENWALD, Jeffrey E, LUCCI, Anthony, ROYAL, Richard, CORMIER, Janice N, DAVIES, Michael A, MANSARAY, Rahmatu, FULBRIGHT, Orenthial J, FOX, Patricia S, TOTH, Christopher, RAMACHANDRAN, Renjith, WARDELL, Seth, GONZALEZ, Audrey, HWU, Patrick, MILLER, Priscilla, CHACON, Jessica, WU, Richard, LIZEE, Gregory, MAHONEY, Sandy, ALVARADO, Gladys

“…Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is a promising treatment for metastatic melanoma unresponsive to conventional…”
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Measuring protein-protein and protein-nucleic Acid interactions by biolayer interferometry by Sultana, Azmiri, Lee, Jeffrey E

“…Biolayer interferometry (BLI) is a simple, optical dip-and-read system useful for measuring interactions between proteins, peptides, nucleic acids, small…”
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Mitochondrial DNA copy number in peripheral blood and melanoma risk by Shen, Jie, Gopalakrishnan, Vancheswaran, Lee, Jeffrey E, Fang, Shenying, Zhao, Hua

“…Mitochondrial DNA (mtDNA) copy number in peripheral blood has been suggested as risk modifier in various types of cancer. However, its influence on melanoma…”
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Validation of a Proposed Tumor Regression Grading Scheme for Pancreatic Ductal Adenocarcinoma After Neoadjuvant Therapy as a Prognostic Indicator for Survival by Lee, Sun Mi, Katz, Matthew H.G, Liu, Li, Sundar, Manonmani, Wang, Hua, Varadhachary, Gauri R, Wolff, Robert A, Lee, Jeffrey E, Maitra, Anirban, Fleming, Jason B, Rashid, Asif, Wang, Huamin

“…Neoadjuvant therapy has been increasingly used to treat patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC). Although the College of…”
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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation by Kano, Yoshihito, Gebregiworgis, Teklab, Marshall, Christopher B., Radulovich, Nikolina, Poon, Betty P. K., St-Germain, Jonathan, Cook, Jonathan D., Valencia-Sama, Ivette, Grant, Benjamin M. M., Herrera, Silvia Gabriela, Miao, Jinmin, Raught, Brian, Irwin, Meredith S., Lee, Jeffrey E., Yeh, Jen Jen, Zhang, Zhong-Yin, Tsao, Ming-Sound, Ikura, Mitsuhiko, Ohh, Michael

“…Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2…”
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Surgeon symptoms, strain, and selections: Systematic review and meta-analysis of surgical ergonomics by Stucky, Chee-Chee H., Cromwell, Kate D., Voss, Rachel K., Chiang, Yi-Ju, Woodman, Karin, Lee, Jeffrey E., Cormier, Janice N.

“…Many surgeons experience work-related pain and musculoskeletal symptoms; however, comprehensive reporting of surgeon ailments is lacking in the literature. We…”
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Phase II Trial of Cetuximab, Gemcitabine, and Oxaliplatin Followed by Chemoradiation With Cetuximab for Locally Advanced (T4) Pancreatic Adenocarcinoma: Correlation of Smad4(Dpc4) Immunostaining With Pattern of Disease Progression by CRANE, Christopher H, VARADHACHARY, Gauri R, DAS, Prajnan, LEE, Jeffrey E, ABBRUZZESE, James L, WOLFF, Robert A, YORDY, John S, STAERKEL, Gregg A, JAVLE, Milind M, SAFRAN, Howard, HAQUE, Waqar, HOBBS, Bridgett D, KRISHNAN, Sunil, FLEMING, Jason B

“…This phase II trial was designed to assess the efficacy and safety of cetuximab, gemcitabine, and oxaliplatin followed by cetuximab, capecitabine, and…”
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Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis by Xu, Xiaohong Ruby, Wang, Yiming, Adili, Reheman, Ju, Lining, Spring, Christopher M., Jin, Joseph Wuxun, Yang, Hong, Neves, Miguel A. D., Chen, Pingguo, Yang, Yan, Lei, Xi, Chen, Yunfeng, Gallant, Reid C., Xu, Miao, Zhang, Hailong, Song, Jina, Ke, Peifeng, Zhang, Dan, Carrim, Naadiya, Yu, Si-Yang, Zhu, Guangheng, She, Yi-Min, Cyr, Terry, Fu, Wenbin, Liu, Guoqing, Connelly, Philip W., Rand, Margaret L., Adeli, Khosrow, Freedman, John, Lee, Jeffrey E., Tso, Patrick, Marchese, Patrizia, Davidson, W. Sean, Jackson, Shaun P., Zhu, Cheng, Ruggeri, Zaverio M., Ni, Heyu

“…Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play key roles in myocardial infarction and stroke. Here we show that…”
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