Search Results - "Jeffrey, Danielle A"
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Optimization of phenol-chloroform RNA extraction
Published in MethodsX (01-01-2018)“…[Display omitted] Accurate and reliable analysis of gene expression depends on the extraction of pure and high-quality RNA. However, while the conventional…”
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LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction
Published in eLife (23-04-2024)“…Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel…”
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Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness
Published in JCI insight (08-10-2021)“…Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and main indication for heart transplantation in children. Therapies specific to…”
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Pediatric dilated cardiomyopathy hearts display a unique gene expression profile
Published in JCI insight (20-07-2017)“…Our previous work showed myocellular differences in pediatric and adult dilated cardiomyopathy (DCM). However, a thorough characterization of the molecular…”
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Ex vivo capillary-parenchymal arteriole approach to study brain pericyte physiology
Published in Neurophotonics (Print) (01-07-2022)“…Significance: Vascular mural cells, defined as smooth muscle cells (SMCs) and pericytes, influence brain microcirculation, but how they contribute is not fully…”
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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism
Published in Neuron (Cambridge, Mass.) (04-09-2024)“…Microglia, the resident immune cells of the central nervous system, are intimately involved in the brain's most basic processes, from pruning neural synapses…”
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Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease
Published in American journal of physiology. Heart and circulatory physiology (01-04-2020)“…Despite advances in both medical and surgical therapies, individuals with single ventricle heart disease (SV) remain at high risk for the development of heart…”
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Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake
Published in Journal of molecular and cellular cardiology (01-10-2021)“…Pediatric dilated cardiomyopathy (pDCM) is characterized by unique age-dependent molecular mechanisms that include myocellular responses to therapy. We…”
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LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction
Published in eLife (23-04-2024)“…Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel…”
Get full text
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Abstract 15529: Age-Specific Expression of Serum Response Factor Deletion 5 Isoform Affects Cardiomyocyte Calcium Reuptake and Whole Cell Relaxation
Published in Circulation (New York, N.Y.) (19-11-2019)“…ObjectivePediatric dilated cardiomyopathy patients respond differently to therapies that are effective in adult dilated cardiomyopathy patients suggesting an…”
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