Search Results - "Jeffers, Victoria"

Seeing the unseen: illuminating Toxoplasma gondii's metabolic manipulation by Huet, Diego, Jeffers, Victoria

“…Intracellular infection by a pathogen induces significant rewiring of host cell signaling and biological processes. Understanding how an intracellular pathogen…”
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Satellite tracking in sea turtles: How do we find our way to the conservation dividends? by Jeffers, Victoria F., Godley, Brendan J.

“…As species of conservation concern, sea turtles have historically been difficult to study because of their elusive nature and extensive ranges, but…”
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"Reading" a new chapter in protozoan parasite transcriptional regulation by Fleck, Krista, Nitz, Malorie, Jeffers, Victoria

“…Protozoan parasites continue to cause a significant health and economic burden worldwide. As infectious organisms, they pose unique and difficult challenges…”
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An apicomplexan bromodomain protein, TgBDP1, associates with diverse epigenetic factors to regulate essential transcriptional processes in Toxoplasma gondii by Fleck, Krista, McNutt, Seth, Chu, Feixia, Jeffers, Victoria

“…The protozoan pathogen relies on tight regulation of gene expression to invade and establish infection in its host. The divergent gene regulatory mechanisms of…”
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Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii by Jeffers, Victoria, Sullivan, William J., Jr

“…While histone proteins are the founding members of lysine acetylation substrates, it is now clear that hundreds of other proteins can be acetylated in multiple…”
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Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii by Bouchut, Anne, Chawla, Aarti R, Jeffers, Victoria, Hudmon, Andy, Sullivan, Jr, William J

“…Lysine acetylation is a reversible post-translational modification (PTM) that has been detected on thousands of proteins in nearly all cellular compartments…”
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Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation by Wang, Jiachen, Dixon, Stacy E, Ting, Li-Min, Liu, Ting-Kai, Jeffers, Victoria, Croken, Matthew M, Calloway, Myrasol, Cannella, Dominique, Hakimi, Mohamed Ali, Kim, Kami, Sullivan, Jr, William J

“…Histone acetylation has been linked to developmental changes in gene expression and is a validated drug target of apicomplexan parasites, but little is known…”
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Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites by Jeffers, Victoria

“…Apicomplexan parasites have complex life cycles, often requiring transmission between two different hosts, facing periods of dormancy within the host or in the…”
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TgPRELID, a Mitochondrial Protein Linked to Multidrug Resistance in the Parasite Toxoplasma gondii by Jeffers, Victoria, Kamau, Edwin T, Srinivasan, Ananth R, Harper, Jonathan, Sankaran, Preethi, Post, Sarah E, Varberg, Joseph M, Sullivan, Jr, William J, Boyle, Jon P

“…New drugs to control infection with the protozoan parasite are needed as current treatments exert toxic side effects on patients. Approaches to develop novel…”
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A latent ability to persist: differentiation in Toxoplasma gondii by Jeffers, Victoria, Tampaki, Zoi, Kim, Kami, Sullivan, William J.

“…A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to convert from an acute disease-causing, proliferative stage…”
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Mechanisms of Toxoplasma gondii persistence and latency by Sullivan, William J., Jeffers, Victoria

“…Abstract Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic disease, particularly in immunocompromised individuals…”
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No acetyl-CoA keeps Plasmodium at bay by Jeffers, Victoria, Child, Matthew A

“…Acetyl-coenzyme A is an important metabolite and regulates diverse cellular processes, including metabolism and epigenetics. In this issue of Cell Chemical…”
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Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development by Jeffers, Victoria, Yang, Chunlin, Huang, Sherri, Sullivan, Jr, William J

“…Parasitic infections remain one of the most pressing global health concerns of our day, affecting billions of people and producing unsustainable economic…”
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Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii by Hanquier, Jocelyne, Gimeno, Thomas, Jeffers, Victoria, Sullivan, William J.

“…Toxoplasma gondii is a protozoan parasite of great importance in human and veterinary health. The frontline treatment of antifolates suffers a variety of…”
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Trialling the use of smartphones as a tool to address gaps in small-scale fisheries catch data in southwest Madagascar by Jeffers, Victoria F., Humber, Frances, Nohasiarivelo, Thierry, Botosoamananto, Radonirina, Anderson, Lucy G.

“…Worldwide, small-scale fisheries (SSFs) contribute over half of global fish and invertebrate catch and generate employment for 90% of those working in the…”
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Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite‐specific functions during Plasmodium falciparum intraerythrocytic development by Miao, Jun, Lawrence, Matthew, Jeffers, Victoria, Zhao, Fangqing, Parker, Daniel, Ge, Ying, Sullivan, William J., Cui, Liwang

“…Summary Lysine acetylation has emerged as a major post‐translational modification involved in diverse cellular functions. Using a combination of…”
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Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii by Jeffers, Victoria, Gao, Hongyu, Checkley, Lisa A, Liu, Yunlong, Ferdig, Michael T, Sullivan, Jr, William J

“…Lysine acetylation is a critical posttranslational modification that influences protein activity, stability, and binding properties. The acetylation of histone…”
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Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains by Phillips, Margaret, Malone, Kiera L., Boyle, Brian W., Montgomery, Cameron, Kressy, Isabelle A., Joseph, Faith M., Bright, Kathleen M., Boyson, Samuel P., Chang, Sunsik, Nix, Jay C., Young, Nicolas L., Jeffers, Victoria, Frietze, Seth, Glass, Karen C.

“…The ATPase family AAA+ domain containing 2 (ATAD2) protein and its paralog ATAD2B have a C-terminal bromodomain (BRD) that functions as a reader of acetylated…”
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The Toxoplasma gondii F-Box Protein L2 Functions as a Repressor of Stage Specific Gene Expression by Baptista, Carlos G, Hosking, Sarah, Gas-Pascual, Elisabet, Ciampossine, Loic, Abel, Steven, Hakimi, Mohamed-Ali, Jeffers, Victoria, Le Roch, Karine, West, Christopher M, Blader, Ira J

“…Toxoplasma gondii is a foodborne pathogen that can cause severe and life-threatening infections in fetuses and immunocompromised patients. Felids are its only…”
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Protein acetylation in the critical biological processes in protozoan parasites by Maran, Suellen Rodrigues, Fleck, Krista, Monteiro-Teles, Natália Melquie, Isebe, Tony, Walrad, Pegine, Jeffers, Victoria, Cestari, Igor, Vasconcelos, Elton J.R., Moretti, Nilmar

“…Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins…”
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