Search Results - "Jeffers, R."

Applying machine learning methods to enable automatic customisation of knee replacement implants from CT data by Burge, Thomas A., Jeffers, Jonathan R. T., Myant, Connor W.

“…The aim of this study was to develop an automated pipeline capable of designing custom total knee replacement implants from CT scans. The developed pipeline…”
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Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis by Kim, Hyungjin, Tu, Ho-Chou, Ren, Decheng, Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.

“…While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we…”
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BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program by Ren, Decheng, Tu, Ho-Chou, Kim, Hyungjin, Wang, Gary X, Bean, Gregory R, Takeuchi, Osamu, Jeffers, John R, Zambetti, Gerard P, Hsieh, James J.-D, Cheng, Emily H.-Y

“…Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in…”
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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies by Cheng, Emily H.-Y, Kim, Hyungjin, Rafiuddin-Shah, Mubina, Tu, Ho-Chou, Jeffers, John R, Zambetti, Gerard P, Hsieh, James J.-D

“…Although the BCL-2 family constitutes a crucial checkpoint in apoptosis, the intricate interplay between these family members remains elusive. Here, we…”
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Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B by Rao, Shuyun, Lee, Sang-Yun, Gutierrez, Alejandro, Perrigoue, Jacqueline, Thapa, Roshan J., Tu, Zhigang, Jeffers, John R., Rhodes, Michele, Anderson, Stephen, Oravecz, Tamas, Hunger, Stephen P., Timakhov, Roman A., Zhang, Rugang, Balachandran, Siddharth, Zambetti, Gerard P., Testa, Joseph R., Look, A. Thomas, Wiest, David L.

“…Ribosomal protein (RP) mutations in diseases such as 5q− syndrome both disrupt hematopoiesis and increase the risk of developing hematologic malignancy…”
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Design and clinical application of injectable hydrogels for musculoskeletal therapy by Øvrebø, Øystein, Perale, Giuseppe, Wojciechowski, Jonathan P., Echalier, Cécile, Jeffers, Jonathan R. T., Stevens, Molly M., Haugen, Håvard J., Rossi, Filippo

“…Musculoskeletal defects are an enormous healthcare burden and source of pain and disability for individuals. With an aging population, the proportion of…”
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A low friction, biphasic and boundary lubricating hydrogel for cartilage replacement by Milner, Piers E., Parkes, Maria, Puetzer, Jennifer L., Chapman, Robert, Stevens, Molly M., Cann, Philippa, Jeffers, Jonathan R.T.

“…[Display omitted] Partial joint repair is a surgical procedure where an artificial material is used to replace localised chondral damage. These artificial…”
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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways by Jeffers, John R., Parganas, Evan, Lee, Youngsoo, Yang, Chunying, Wang, JinLing, Brennan, Jennifer, MacLean, Kirsteen H., Han, Jiawen, Chittenden, Thomas, Ihle, James N., McKinnon, Peter J., Cleveland, John L., Zambetti, Gerard P.

“…Puma encodes a BH3-only protein that is induced by the p53 tumor suppressor and other apoptotic stimuli. To assess its physiological role in apoptosis, we…”
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Does Capsular Laxity Lead to Microinstability of the Native Hip? by Han, Shuyang, Alexander, Jerry W., Thomas, Vijai S., Choi, Joshua, Harris, Joshua D., Doherty, David B., Jeffers, Jonathan R.T., Noble, Philip C.

“…Background: Hip “microinstability” is commonly cited as the cause of symptoms that occur in the presence of translation of the femoral head away from…”
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The correlation between metabolic and individual leg mechanical power during walking at different slopes and velocities by Jeffers, Jana R, Auyang, Arick G, Grabowski, Alena M

“…Abstract During level-ground walking, mechanical work from each leg is required to redirect and accelerate the center of mass. Previous studies show a linear…”
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Anatomic Predictors of Sagittal Hip and Pelvic Motions in Patients With a Cam Deformity by Ng, K.C. Geoffrey, Lamontagne, Mario, Jeffers, Jonathan R.T., Grammatopoulos, George, Beaulé, Paul E.

“…Background: As there is a high prevalence of patients with cam deformities and no ongoing hip dysfunction, understanding the biomechanical factors predicting…”
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Validity of repeated-measures analyses of in vitro arthroplasty kinematics and kinetics by Dandridge, Oliver, Garner, Amy, Jeffers, Jonathan R.T., Amis, Andrew A., Cobb, Justin P., van Arkel, Richard J.

“…In vitro models of arthroplasty enable pre-clinical testing and inform clinical decision making. Repeated-measures comparisons maximise resource efficiency,…”
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Total and partial knee arthroplasty implants that maintain native load transfer in the tibia by Munford, Maxwell J, Stoddart, Jennifer C, Liddle, Alexander D, Cobb, Justin P, Jeffers, Jonathan R T

“…Unicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural…”
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The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo by Kuribayashi, Kageaki, Finnberg, Niklas K., Jeffers, John R., Zambetti, Gerard P., El-Deiry, Wafik S.

“…The p53 pathway displays a large degree of redundancy in the expression of a number of pro-apoptotic mechanisms following DNA damage that, among others,…”
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Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis by Garrison, Sean P., Jeffers, John R., Yang, Chunying, Nilsson, Jonas A., Hall, Mark A., Rehg, Jerold E., Yue, Wen, Yu, Jian, Zhang, Lin, Onciu, Mihaela, Sample, Jeffery T., Cleveland, John L., Zambetti, Gerard P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Quantifying 3D Strain in Scaffold Implants for Regenerative Medicine by Clark, Jeffrey N, Tavana, Saman, Heyraud, Agathe, Tallia, Francesca, Jones, Julian R, Hansen, Ulrich, Jeffers, Jonathan R T

“…Regenerative medicine solutions require thoughtful design to elicit the intended biological response. This includes the biomechanical stimulus to generate an…”
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An in vitro model of impaction during hip arthroplasty by Doyle, Ruben, Boughton, Oliver, Plant, Daniel, Desoutter, George, Cobb, Justin P., Jeffers, Jonathan R.T.

“…Impaction is required to properly seat press-fit implants and ensure initial implant stability and long term bone ingrowth, however excessive impaction or…”
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Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue-Biomaterial Interface in an Ovine Model by Clark, Jeffrey N, Heyraud, Agathe, Tavana, Saman, Al-Jabri, Talal, Tallia, Francesca, Clark, Brett, Blunn, Gordon W, Cobb, Justin P, Hansen, Ulrich, Jones, Julian R, Jeffers, Jonathan R T

“…Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new…”
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Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion by Toth, Ambrus, Jeffers, John R, Nickson, Philip, Min, Jiang-Yong, Morgan, James P, Zambetti, Gerard P, Erhardt, Peter

“…The p53-upregulated modulator of apoptosis (Puma), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of…”
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Capsular ligaments provide a passive stabilizing force to protect the hip against edge loading by Karunaseelan, Kabelan J., Dandridge, Oliver, Muirhead-Allwood, Sarah K., van Arkel, Richard J., Jeffers, Jonathan R. T.

“…Aims In the native hip, the hip capsular ligaments tighten at the limits of range of hip motion and may provide a passive stabilizing force to protect the hip…”
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