Search Results - "Jefferies, Sarah"

COVID-19 in New Zealand and the impact of the national response: a descriptive epidemiological study by Jefferies, Sarah, French, Nigel, Gilkison, Charlotte, Graham, Giles, Hope, Virginia, Marshall, Jonathan, McElnay, Caroline, McNeill, Andrea, Muellner, Petra, Paine, Shevaun, Prasad, Namrata, Scott, Julia, Sherwood, Jillian, Yang, Liang, Priest, Patricia

“…In early 2020, during the COVID-19 pandemic, New Zealand implemented graduated, risk-informed national COVID-19 suppression measures aimed at disease…”
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Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial by Nutting, Christopher M, Dr, Morden, James P, MSc, Harrington, Kevin J, FRCR, Urbano, Teresa Guerrero, PhD, Bhide, Shreerang A, FRCR, Clark, Catharine, PhD, Miles, Elizabeth A, MPhil, Miah, Aisha B, FRCR, Newbold, Kate, FRCR, Tanay, MaryAnne, MSc, Adab, Fawzi, FRCR, Jefferies, Sarah J, FRCR, Scrase, Christopher, FRCR, Yap, Beng K, FRCR, A'Hern, Roger P, MSc, Sydenham, Mark A, BSc, Emson, Marie, BSc, Hall, Emma, PhD

“…Summary Background Xerostomia is the most common late side-effect of radiotherapy to the head and neck. Compared with conventional radiotherapy,…”
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Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial by Hanna, Catherine, Kurian, Kathreena M, Williams, Karin, Watts, Colin, Jackson, Alan, Carruthers, Ross, Strathdee, Karen, Cruickshank, Garth, Dunn, Laurence, Erridge, Sara, Godfrey, Lisa, Jefferies, Sarah, McBain, Catherine, Sleigh, Rebecca, McCormick, Alex, Pittman, Marc, Halford, Sarah, Chalmers, Anthony J

“…Abstract Background The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib potentiated radiation and temozolomide (TMZ) chemotherapy in preclinical…”
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Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042) by Weber, Damien C., Ares, Carmen, Villa, Salvador, Peerdeman, Saskia M., Renard, Laurette, Baumert, Brigitta G., Lucas, Anna, Veninga, Theo, Pica, Alessia, Jefferies, Sarah, Ricardi, Umberto, Miralbell, Raymond, Stelmes, Jean-Jacques, Liu, Yan, Collette, Laurence, Collette, Sandra

“…The therapeutic strategy for non-benign meningiomas is controversial. The objective of this study was to prospectively investigate the impact of high dose…”
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Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand by Geoghegan, Jemma L., Ren, Xiaoyun, Storey, Matthew, Hadfield, James, Jelley, Lauren, Jefferies, Sarah, Sherwood, Jill, Paine, Shevaun, Huang, Sue, Douglas, Jordan, Mendes, Fábio K., Sporle, Andrew, Baker, Michael G., Murdoch, David R., French, Nigel, Simpson, Colin R., Welch, David, Drummond, Alexei J., Holmes, Edward C., Duchêne, Sebastián, de Ligt, Joep

“…New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide ‘lockdown’ of all non-essential services to curb the…”
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Prevention of radiotherapy-induced neurocognitive dysfunction in survivors of paediatric brain tumours: the potential role of modern imaging and radiotherapy techniques by Ajithkumar, Thankamma, Dr, Price, Stephen, PhD, Horan, Gail, FRCR, Burke, Amos, PhD, Jefferies, Sarah, PhD

“…Summary Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term survivors of paediatric brain tumours. Radiotherapy is one of…”
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Evolving treatment options for melanoma brain metastases by Ajithkumar, Thankamma, Dr, Parkinson, Christine, PhD, Fife, Kate, MD, Corrie, Pippa, PhD, Jefferies, Sarah, PhD

“…Summary Melanoma is a leading cause of lost productivity due to premature cancer mortality. Melanoma frequently spreads to the brain and is associated with…”
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Genomic Evidence of In-Flight Transmission of SARS-CoV-2 Despite Predeparture Testing by Swadi, Tara, Geoghegan, Jemma L, Devine, Tom, McElnay, Caroline, Sherwood, Jillian, Shoemack, Phil, Ren, Xiaoyun, Storey, Matt, Jefferies, Sarah, Smit, Erasmus, Hadfield, James, Kenny, Aoife, Jelley, Lauren, Sporle, Andrew, McNeill, Andrea, Reynolds, G Edwin, Mouldey, Kip, Lowe, Lindsay, Sonder, Gerard, Drummond, Alexei J, Huang, Sue, Welch, David, Holmes, Edward C, French, Nigel, Simpson, Colin R, de Ligt, Joep

“…Since the first wave of coronavirus disease in March 2020, citizens and permanent residents returning to New Zealand have been required to undergo managed…”
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A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma by Hall, Peter E, Lewis, Rachel, Syed, Nelofer, Shaffer, Richard, Evanson, Jane, Ellis, Stephen, Williams, Matthew, Feng, Xiaoxing, Johnston, Amanda, Thomson, Jim A, Harris, Fiona P, Jena, Raj, Matys, Tomasz, Jefferies, Sarah, Smith, Kate, Wu, Bor-Wen, Bomalaski, John S, Crook, Timothy, O'Neill, Kevin, Paraskevopoulos, Dimitris, Khadeir, Ramsay S, Sheaff, Michael, Pacey, Simon, Plowman, Piers N, Szlosarek, Peter W

“…Patients with recurrent high-grade gliomas (HGG) are usually managed with alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor…”
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Use of Genomics to Track Coronavirus Disease Outbreaks, New Zealand by Geoghegan, Jemma L, Douglas, Jordan, Ren, Xiaoyun, Storey, Matthew, Hadfield, James, Silander, Olin K, Freed, Nikki E, Jelley, Lauren, Jefferies, Sarah, Sherwood, Jillian, Paine, Shevaun, Huang, Sue, Sporle, Andrew, Baker, Michael G, Murdoch, David R, Drummond, Alexei J, Welch, David, Simpson, Colin R, French, Nigel, Holmes, Edward C, de Ligt, Joep

“…Real-time genomic sequencing has played a major role in tracking the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),…”
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Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord by Noble, David J., Yeap, Ping-Lin, Seah, Shannon Y.K., Harrison, Karl, Shelley, Leila E.A., Romanchikova, Marina, Bates, Amy M., Zheng, Yaolin, Barnett, Gillian C., Benson, Richard J., Jefferies, Sarah J., Thomas, Simon J., Jena, Raj, Burnet, Neil G.

“…•A cohort of 133 head & neck cancer patients treated with TomoTherapy was examined.•Differences between planned and delivered maximum spinal cord dose were…”
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Intra-operative extracorporeal irradiation of tumour-invaded craniotomy bone flap in meningioma: a case series by Cook, William H., Burton, Katherine, Jefferies, Sarah J., Duke, Simon L., Jena, Rajesh, Burnet, Neil G., Kirollos, Ramez W., Helmy, Adel E., Santarius, Thomas

“…Background Extracorporeal irradiation of tumorous calvaria (EITC) can be performed to restore function and form of the skull after resection of bone-invasive…”
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Creating symptom-based criteria for diagnostic testing: a case study based on a multivariate analysis of data collected during the first wave of the COVID-19 pandemic in New Zealand by French, Nigel, Jones, Geoff, Heuer, Cord, Hope, Virginia, Jefferies, Sarah, Muellner, Petra, McNeill, Andrea, Haslett, Stephen, Priest, Patricia

“…Abstract Background Diagnostic testing using PCR is a fundamental component of COVID-19 pandemic control. Criteria for determining who should be tested by PCR…”
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Adult brain tumour research in 2024: Status, challenges and recommendations by Purshouse, Karin, Bulbeck, Helen J., Rooney, Alasdair G., Noble, Karen E., Carruthers, Ross D., Thompson, Gerard, Hamerlik, Petra, Yap, Christina, Kurian, Kathreena M., Jefferies, Sarah J., Lopez, Juanita S., Jenkinson, Michael D., Hanemann, C. Oliver, Stead, Lucy F.

“…In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and…”
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Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma by Booth, Thomas C, Larkin, Timothy J, Yuan, Yinyin, Kettunen, Mikko I, Dawson, Sarah N, Scoffings, Daniel, Canuto, Holly C, Vowler, Sarah L, Kirschenlohr, Heide, Hobson, Michael P, Markowetz, Florian, Jefferies, Sarah, Brindle, Kevin M

“…To develop an image analysis technique that distinguishes pseudoprogression from true progression by analyzing tumour heterogeneity in T2-weighted images using…”
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The Conditional Probability of Vestibular Schwannoma Growth at Different Time Points After Initial Stability on an Observational Protocol by Sethi, Mantegh, Borsetto, Daniele, Cho, Yeajoon, Gair, Juliette, Gamazo, Nicola, Jefferies, Sarah, Joannides, Alexis, Mannion, Richard, Helmy, Adel, Axon, Patrick, Donnelly, Neil, Tysome, James R., Bance, Manohar

“…OBJECTIVE:The natural history of vestibular schwannomas (VS) is well documented in the literature, with tumour growth being paramount to decision making for…”
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Response to BRAF and MEK1/2 inhibition in a young adult with BRAF V600E mutant epithelioid glioblastoma multiforme: A Case Report and Literature Review by Venkatesh, Ashwin, Joshi, Amol, Allinson, Kieren, Das, Tilak, Santarius, Thomas, Jefferies, Sarah J., Harris, Fiona P., Jena, Rajesh, Doherty, Gary J.

“…Epithelioid glioblastoma multiforme (eGBM) is a rare and aggressive variant of glioblastoma multiforme (GBM) that predominantly affects younger patients and…”
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Fast imaging employing steady-state acquisition (FIESTA) MRI to investigate cerebrospinal fluid (CSF) within dural reflections of posterior fossa cranial nerves by Noble, David J, Scoffings, Daniel, Ajithkumar, Thankamma, Williams, Michael V, Jefferies, Sarah J

“…There is no consensus approach to covering skull base meningeal reflections-and cerebrospinal fluid (CSF) therein-of the posterior fossa cranial nerves (CNs…”
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A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects by Barazzuol, Lara, Burnet, Neil G., Jena, Raj, Jones, Bleddyn, Jefferies, Sarah J., Kirkby, Norman F.

“…Glioblastoma is the most frequent and malignant brain tumour. For many years, the conventional treatment has been maximal surgical resection followed by…”
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PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT status by Fulton, Ben, Short, Susan C., James, Allan, Nowicki, Stefan, McBain, Catherine, Jefferies, Sarah, Kelly, Caroline, Stobo, Jon, Morris, Anna, Williamson, Aoife, Chalmers, Anthony J.

“…•The manuscript details the rationale, design and protocol for PARADIGM-2.•PARADIGM-2 comprises two parallel phase I, dose escalation studies of the PARP…”
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