Search Results - "Jeff, Janina M."

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis by Fernández-Rhodes, Lindsay, Malinowski, Jennifer R, Wang, Yujie, Tao, Ran, Pankratz, Nathan, Jeff, Janina M, Yoneyama, Sachiko, Carty, Cara L, Setiawan, V Wendy, Le Marchand, Loic, Haiman, Christopher, Corbett, Steven, Demerath, Ellen, Heiss, Gerardo, Gross, Myron, Buzkova, Petra, Crawford, Dana C, Hunt, Steven C, Rao, D C, Schwander, Karen, Chakravarti, Aravinda, Gottesman, Omri, Abul-Husn, Noura S, Bottinger, Erwin P, Loos, Ruth J F, Raffel, Leslie J, Yao, Jie, Guo, Xiuqing, Bielinski, Suzette J, Rotter, Jerome I, Vaidya, Dhananjay, Chen, Yii-Der Ida, Castañeda, Sheila F, Daviglus, Martha, Kaplan, Robert, Talavera, Gregory A, Ryckman, Kelli K, Peters, Ulrike, Ambite, Jose Luis, Buyske, Steven, Hindorff, Lucia, Kooperberg, Charles, Matise, Tara, Franceschini, Nora, North, Kari E

“…Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European…”
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A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans by Pendergrass, Sarah A, Buyske, Steven, Jeff, Janina M, Frase, Alex, Dudek, Scott, Bradford, Yuki, Ambite, Jose-Luis, Avery, Christy L, Buzkova, Petra, Deelman, Ewa, Fesinmeyer, Megan D, Haiman, Christopher, Heiss, Gerardo, Hindorff, Lucia A, Hsu, Chun-Nan, Jackson, Rebecca D, Lin, Yi, Le Marchand, Loic, Matise, Tara C, Monroe, Kristine R, Moreland, Larry, North, Kari E, Park, Sungshim L, Reiner, Alex, Wallace, Robert, Wilkens, Lynne R, Kooperberg, Charles, Ritchie, Marylyn D, Crawford, Dana C

“…We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is…”
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Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans by Delaney, Jessica T, Jeff, Janina M, Brown, Nancy J, Pretorius, Mias, Okafor, Henry E, Darbar, Dawood, Roden, Dan M, Crawford, Dana C

“…Despite a greater burden of risk factors, atrial fibrillation (AF) is less common among African Americans than European-descent populations. Genome-wide…”
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Genetic variation in the β1 -adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery by Jeff, Janina M., PhD, Donahue, Brian S., MD, PhD, Brown-Gentry, Kristin, MS, Roden, Dan M., MD, Crawford, Dana C., PhD, Stein, C. Michael, MD, Kurnik, Daniel, MD

“…Background Postoperative atrial fibrillation (PoAF) after cardiac surgery is common and associated with increased morbidity and mortality. Increased…”
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Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans by Jeff, Janina M, Armstrong, Loren L, Ritchie, Marylyn D, Denny, Joshua C, Kho, Abel N, Basford, Melissa A, Wolf, Wendy A, Pacheco, Jennifer A, Li, Rongling, Chisholm, Rex L, Roden, Dan M, Hayes, M Geoffrey, Crawford, Dana C

“…Type 2 diabetes (T2D) is a complex metabolic disease that disproportionately affects African Americans. Genome-wide association studies (GWAS) have identified…”
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Fine-mapping and initial characterization of QT interval loci in African Americans by Avery, Christy L, Sethupathy, Praveen, Buyske, Steven, He, Qianchuan, Lin, Dan-Yu, Arking, Dan E, Carty, Cara L, Duggan, David, Fesinmeyer, Megan D, Hindorff, Lucia A, Jeff, Janina M, Klein, Liviu, Patton, Kristen K, Peters, Ulrike, Shohet, Ralph V, Sotoodehnia, Nona, Young, Alicia M, Kooperberg, Charles, Haiman, Christopher A, Mohlke, Karen L, Whitsel, Eric A, North, Kari E

“…The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have…”
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What can we learn about lipoprotein metabolism and coronary heart disease from studying rare variants? by Jeff, Janina M, Peloso, Gina M, Do, Ron

“…Rare variant association studies (RVAS) target the class of genetic variation with frequencies less than 1%. Recently, investigators have used exome sequencing…”
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Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry by Wenric, Stephane, Jeff, Janina M., Joseph, Thomas, Yee, Muh-Ching, Belbin, Gillian M., Owusu Obeng, Aniwaa, Ellis, Stephen B., Bottinger, Erwin P., Gottesman, Omri, Levin, Matthew A., Kenny, Eimear E.

“…The emergence of genomic data in biobanks and health systems offers new ways to derive medically important phenotypes, including acute phenotypes occurring…”
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Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system by Belbin, Gillian Morven, Odgis, Jacqueline, Sorokin, Elena P, Yee, Muh-Ching, Kohli, Sumita, Glicksberg, Benjamin S, Gignoux, Christopher R, Wojcik, Genevieve L, Van Vleck, Tielman, Jeff, Janina M, Linderman, Michael, Schurmann, Claudia, Ruderfer, Douglas, Cai, Xiaoqiang, Merkelson, Amanda, Justice, Anne E, Young, Kristin L, Graff, Misa, North, Kari E, Peters, Ulrike, James, Regina, Hindorff, Lucia, Kornreich, Ruth, Edelmann, Lisa, Gottesman, Omri, Stahl, Eli Ea, Cho, Judy H, Loos, Ruth Jf, Bottinger, Erwin P, Nadkarni, Girish N, Abul-Husn, Noura S, Kenny, Eimear E

“…Achieving confidence in the causality of a disease locus is a complex task that often requires supporting data from both statistical genetics and clinical…”
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A multi-stage genome-wide association study of uterine fibroids in African Americans by Hellwege, Jacklyn N., Jeff, Janina M., Wise, Lauren A., Gallagher, C. Scott, Wellons, Melissa, Hartmann, Katherine E., Jones, Sarah F., Torstenson, Eric S., Dickinson, Scott, Ruiz-Narváez, Edward A., Rohland, Nadin, Allen, Alexander, Reich, David, Tandon, Arti, Pasaniuc, Bogdan, Mancuso, Nicholas, Im, Hae Kyung, Hinds, David A., Palmer, Julie R., Rosenberg, Lynn, Denny, Joshua C., Roden, Dan M., Stewart, Elizabeth A., Morton, Cynthia C., Kenny, Eimear E., Edwards, Todd L., Velez Edwards, Digna R.

“…Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by menopause. They are the leading indication for hysterectomy, and account for…”
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A Trans -Ethnic Genome-Wide Association Study of Uterine Fibroids by Edwards, Todd L, Giri, Ayush, Hellwege, Jacklyn N, Hartmann, Katherine E, Stewart, Elizabeth A, Jeff, Janina M, Bray, Michael J, Pendergrass, Sarah A, Torstenson, Eric S, Keaton, Jacob M, Jones, Sarah H, Gogoi, Radhika P, Kuivaniemi, Helena, Jackson, Kathryn L, Kho, Abel N, Kullo, Iftikhar J, McCarty, Catherine A, Im, Hae Kyung, Pacheco, Jennifer A, Pathak, Jyotishman, Williams, Marc S, Tromp, Gerard, Kenny, Eimear E, Peissig, Peggy L, Denny, Joshua C, Roden, Dan M, Velez Edwards, Digna R

“…Uterine fibroids affect up to 77% of women by menopause and account for up to $34 billion in healthcare costs each year. Although fibroid risk is heritable,…”
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Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin by Xu, Hua, Jiang, Min, Oetjens, Matt, Bowton, Erica A, Ramirez, Andrea H, Jeff, Janina M, Basford, Melissa A, Pulley, Jill M, Cowan, James D, Wang, Xiaoming, Ritchie, Marylyn D, Masys, Daniel R, Roden, Dan M, Crawford, Dana C, Denny, Joshua C

“…DNA biobanks linked to comprehensive electronic health records systems are potentially powerful resources for pharmacogenetic studies. This study sought to…”
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Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations by Avery, Christy L., Wassel, Christina L., Richard, Melissa A., Highland, Heather M., Bien, Stephanie, Zubair, Niha, Soliman, Elsayed Z., Fornage, Myriam, Bielinski, Suzette J., Tao, Ran, Seyerle, Amanda A., Shah, Sanjiv J., Lloyd-Jones, Donald M., Buyske, Steven, Rotter, Jerome I., Post, Wendy S., Rich, Stephen S., Hindorff, Lucia A., Jeff, Janina M., Shohet, Ralph V., Sotoodehnia, Nona, Lin, Dan Yu, Whitsel, Eric A., Peters, Ulrike, Haiman, Christopher A., Crawford, Dana C., Kooperberg, Charles, North, Kari E.

“…The electrocardiographically measured QT interval (QT) is heritable and its prolongation is an established risk factor for several cardiovascular diseases…”
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Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations by Jeff, Janina M, Brown-Gentry, Kristin, Crawford, Dana C

“…Elevated levels of plasma fibrinogen are associated with clot formation in the absence of inflammation or injury and is a biomarker for arterial clotting, the…”
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iGAS: A framework for using electronic intraoperative medical records for genomic discovery by Levin, Matthew A., Joseph, Thomas T., Jeff, Janina M., Nadukuru, Rajiv, Ellis, Stephen B., Bottinger, Erwin P., Kenny, Eimear E.

“…[Display omitted] •Genetic variation may play an important role in the physiologic response to anesthesia.•An automated pipeline was built to link anesthetic…”
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Evidence of Heterogeneity by Race/Ethnicity in Genetic Determinants of QT Interval by Seyerle, Amanda A., Young, Alicia M., Jeff, Janina M., Melton, Phillip E., Jorgensen, Neal W., Lin, Yi, Carty, Cara L., Deelman, Ewa, Heckbert, Susan R., Hindorff, Lucia A., Jackson, Rebecca D., Martin, Lisa W., Okin, Peter M., Perez, Marco V., Psaty, Bruce M., Soliman, Elsayed Z., Whitsel, Eric A., North, Kari E., Laston, Sandra, Kooperberg, Charles, Avery, Christy L.

“…Background: QT interval (QT) prolongation is an established risk factor for ventricular tachyarrhythmia and sudden cardiac death. Previous genome-wide…”
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Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey by Jeff, Janina M, Brown-Gentry, Kristin, Crawford, Dana C

“…Previous genetic association studies of the fibrinogen gene cluster have identified associations with plasma fibrinogen levels. These studies are typically…”
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Generalization of Variants Identified by Genome‐Wide Association Studies for Electrocardiographic Traits in African Americans by Jeff, Janina M., Ritchie, Marylyn D., Denny, Joshua C., Kho, Abel N., Ramirez, Andrea H., Crosslin, David, Armstrong, Loren, Basford, Melissa A., Wolf, Wendy A., Pacheco, Jennifer A., Chisholm, Rex L., Roden, Dan M., Hayes, M. Geoffrey, Crawford, Dana C.

“…Summary Electrocardiographic (ECG) measurements vary by ancestry. Genome‐wide association studies (GWAS) have identified loci that contribute to ECG…”
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Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans by Hellwege, Jacklyn N., Jeff, Janina M., Wise, Lauren A., Gallagher, C. Scott, Wellons, Melissa, Hartmann, Katherine E., Jones, Sarah F., Torstenson, Eric S., Dickinson, Scott, Ruiz-Narváez, Edward A., Rohland, Nadin, Allen, Alexander, Reich, David, Tandon, Arti, Pasaniuc, Bogdan, Mancuso, Nicholas, Im, Hae Kyung, Hinds, David A., Palmer, Julie R., Rosenberg, Lynn, Denny, Joshua C., Roden, Dan M., Stewart, Elizabeth A., Morton, Cynthia C., Kenny, Eimear E., Edwards, Todd L., Velez Edwards, Digna R.

“…The article “A multi-stage genome-wide association study of uterine fibroids in African Americans”, written by Jacklyn N. Hellwege, was originally published…”
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Fine mapping of QT regions in global populations refines previously identified QT loci and identifies signals unique to African and Hispanic descent populations by Avery, Christy L., PhD, Wassel, Christina L., PhD, Richard, Melissa A., PhD, Highland, Heather M., PhD, Bien, Stephanie, PhD, Zubair, Niha, PhD, Soliman, Elsayed Z., MD, Fornage, Myriam, PhD, Bielinski, Suzette J., PhD, Tao, Ran, PhD, Seyerle, Amanda A., PhD, Shah, Sanjiv J., MD, Lloyd-Jones, Donald M., MD, ScM, Buyske, Steven, PhD, Rotter, Jerome I., MD, Post, Wendy S., MD, MS, Rich, Stephen S., PhD, Hindorff, Lucia A., PhD, Jeff, Janina M., PhD, Shohet, Ralph V., MD, Sotoodehnia, Nona, MD, MPH, Lin, Dan Yu, PhD, Whitsel, Eric A., MD, MPH, Peters, Ulrike, PhD, Haiman, Christopher A., PhD, Crawford, Dana C., PhD, Kooperberg, Charles, PhD, North, Kari E., PhD, MS

“…Background The electrocardiographically measured QT interval (QT) is heritable and its prolongation is an established risk factor for several cardiovascular…”
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