Search Results - "Jeanblanc, Jerome"

Sex-specific decision-making impairments and striatal dopaminergic changes after binge drinking history in rats by Sauton, Pierre, Jeanblanc, Jerome, Benzerouk, Farid, Gierski, Fabien, Naassila, Mickael

“…Binge drinking (BD) is a harmful behavior for health and is a predictive factor for the development of alcohol addiction. Weak decision-making (DM) capacities…”
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Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking by Jeanblanc, Jerome, He, Dao-Yao, Carnicella, Sebastien, Kharazia, Viktor, Janak, Patricia H, Ron, Dorit

“…We previously found that brain-derived neurotrophic factor (BDNF)-haplodeficient mice exhibit greater ethanol-induced place preference and psychomotor…”
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Is self-compassion linked to treatment adherence in schizophrenia? by Uzer-Kremers, Laura, Bralet, Marie-Cécile, Angerville, Bernard, Jeanblanc, Jérôme, Pierrefiche, Olivier, Martinetti, Margaret P., Naassila, Mickaël, Dervaux, Alain

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GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse by Carnicella, Sebastien, Kharazia, Viktor, Jeanblanc, Jerome, Janak, Patricia H, Ron, Dorit

“…Previously, we demonstrated that the action of the natural alkaloid, ibogaine, to reduce alcohol (ethanol) consumption is mediated by the glial cell…”
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Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism by Meinhardt, Marcus W, Pfarr, Simone, Fouquet, Grégory, Rohleder, Cathrin, Meinhardt, Manuela L, Barroso-Flores, Janet, Hoffmann, Rebecca, Jeanblanc, Jérôme, Paul, Elisabeth, Wagner, Konstantin, Hansson, Anita C, Köhr, Georg, Meier, Nils, von Bohlen Und Halbach, Oliver, Bell, Richard L, Endepols, Heike, Neumaier, Bernd, Schönig, Kai, Bartsch, Dusan, Naassila, Mickaël, Spanagel, Rainer, Sommer, Wolfgang H

“…Alcohol-dependent patients commonly show impairments in executive functions that facilitate craving and can lead to relapse. However, the molecular mechanisms…”
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Plasma tau, NfL, GFAP and UCHL1 as candidate biomarkers of alcohol withdrawal‐associated brain damage: A pilot study by Clergue‐Duval, Virgile, Vrillon, Agathe, Jeanblanc, Jérôme, Questel, Frank, Azuar, Julien, Fouquet, Grégory, Mouton‐Liger, François, Rollet, Dorian, Hispard, Eric, Bouaziz‐Amar, Elodie, Bloch, Vanessa, Dereux, Alexandra, Cognat, Emmanuel, Marie‐Claire, Cynthia, Laplanche, Jean‐Louis, Bellivier, Frank, Paquet, Claire, Naassila, Mickael, Vorspan, Florence

“…In this translational study, we investigated the plasma tau protein, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP) and ubiquitin…”
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Face validity of a pre‐clinical model of operant binge drinking: just a question of speed by Jeanblanc, Jérôme, Sauton, Pierre, Jeanblanc, Virginie, Legastelois, Rémi, Echeverry‐Alzate, Victor, Lebourgeois, Sophie, Gonzalez‐Marin, Maria, Naassila, Mickaël

“…Binge drinking (BD) is often defined as a large amount of alcohol consumed in a ‘short’ period of time or ‘per occasion’. In clinical research, few researchers…”
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Interest of new alkylsulfonylhydrazide-type compound in the treatment of alcohol use disorders by Jeanblanc, Jérôme, Bourguet, Erika, Sketriené, Diana, Gonzalez, Céline, Moroy, Gautier, Legastelois, Rémi, Létévé, Mathieu, Trussardi-Régnier, Aurélie, Naassila, Mickaël

“…Rationale Recent preclinical research suggested that histone deacetylase inhibitors (HDACIs) and specifically class I HDAC selective inhibitors might be useful…”
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Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior by Wang, Jun, Carnicella, Sebastien, Phamluong, Khanhky, Jeanblanc, Jerome, Ronesi, Jennifer A, Chaudhri, Nadia, Janak, Patricia H, Lovinger, David M, Ron, Dorit

“…Addiction is characterized by compulsive alcohol or drug taking and seeking, and the dorsal striatum has been implicated in such maladaptive persistent habits…”
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Unexpected effect of cyclodepsipeptides bearing a sulfonylhydrazide moiety towards histone deacetylase activity by Létévé, Mathieu, Gonzalez, Céline, Moroy, Gautier, Martinez, Agathe, Jeanblanc, Jérôme, Legastelois, Rémi, Naassila, Mickaël, Sapi, Janos, Bourguet, Erika

“…[Display omitted] •Synthesis of novel cyclodepsipeptide alkyl/arylsulfonylhydrazide based derivatives.•Compounds 5 and 8 exhibited the best activities towards…”
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Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption by He, Dao-Yao, McGough, Nancy N. H, Ravindranathan, Ajay, Jeanblanc, Jerome, Logrip, Marian L, Phamluong, Khanhky, Janak, Patricia H, Ron, Dorit

“…Alcohol addiction manifests as uncontrolled drinking despite negative consequences. Few medications are available to treat the disorder. Anecdotal reports…”
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Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward by Gibb, Stuart L, Jeanblanc, Jerome, Barak, Segev, Yowell, Quinn V, Yaka, Rami, Ron, Dorit

“…We report here that the Src family tyrosine kinase Lyn negatively regulates the release of dopamine (DA) in the mesolimbic system, as well as the rewarding…”
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Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats by Jeanblanc, Jérôme, Bordy, Romain, Fouquet, Grégory, Jeanblanc, Virginie, Naassila, Mickaël

“…The use of psilocybin to treat alcohol use disorder is very promising, but the mechanisms of action remain poorly understood. We combined behavioral,…”
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Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD) by Bourguet, Erika, Ozdarska, Katarzyna, Moroy, Gautier, Jeanblanc, Jérôme, Naassila, Mickaël

“…Alcohol use disorder (AUD) represents a serious public health issue, and discovery of new therapies is a pressing necessity. Alcohol exposure has been widely…”
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Animal models of binge drinking, current challenges to improve face validity by Jeanblanc, Jérôme, Rolland, Benjamin, Gierski, Fabien, Martinetti, Margaret P., Naassila, Mickael

“…•Binge drinking (BD) is an increasing public health issue that needs to be better defined in humans.•BD is associated with brain damages and cognitive deficits…”
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GPCR and Alcohol-Related Behaviors in Genetically Modified Mice by Neasta, Jérémie, Darcq, Emmanuel, Jeanblanc, Jérôme, Carnicella, Sebastien, Ben Hamida, Sami

“…G protein–coupled receptors (GPCRs) constitute the largest class of cell surface signaling receptors and regulate major neurobiological processes. Accordingly,…”
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Validity and usefulness of the short form of the Drinking Motives Questionnaire Revised (DMQ-R SF) among patients with schizophrenia by Gierski, Fabien, Benzerouk, Farid, Jeanblanc, Jérôme, Angerville, Bernard, Dervaux, Alain, Kaladjian, Arthur, Naassila, Mickaël

“…•We investigated drinking motives among outpatients with schizophrenia.•Results supported the psychometric validity of the DMQ-R SF in schizophrenia.•Comorbid…”
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Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat by Lebourgeois, Sophie, Vilpoux, Catherine, Jeanblanc, Jérôme, Acher, Francine, Marie, Nicolas, Noble, Florence, Naassila, Mickaël

“…Addiction is a chronic and highly relapsing disorder hypothesized to be produced by an imbalance between excitatory and inhibitory neurotransmission. For more…”
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Interstrain differences in voluntary binge‐like drinking behavior and in two acute ethanol injections‐induced synaptic plasticity deficits in rats by Sauton, Pierre, Deschamps, Chloé, Jeanblanc, Virginie, Pierrefiche, Olivier, Jeanblanc, Jérôme, Naassila, Mickael

“…Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the…”
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Sex-related differences in the efficacy of Baclofen enantiomers on self-administered alcohol in a binge drinking pattern and dopamine release in the core of the nucleus accumbens by Jeanblanc, Jérôme, Sauton, Pierre, Houdant, Charles, Fernandez Rodriguez, Sandra, de Sousa, Sofia Vilelas, Jeanblanc, Virginie, Bodeau, Sandra, Labat, Laurence, Soichot, Marion, Vorspan, Florence, Naassila, Mickael

“…Clinical studies on the effectiveness of Baclofen in alcohol use disorder (AUD) yielded mixed results possibly because of differential effects of the…”
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