Search Results - "Jean-Marc Schlaeppi"

Biochemical characterization of USP7 reveals post‐translational modification sites and structural requirements for substrate processing and subcellular localization by Fernández‐Montalván, Amaury, Bouwmeester, Tewis, Joberty, Gerard, Mader, Robert, Mahnke, Marion, Pierrat, Benoit, Schlaeppi, Jean‐Marc, Worpenberg, Susanne, Gerhartz, Bernd

“…Ubiquitin specific protease 7 (USP7) belongs to the family of deubiquitinating enzymes. Among other functions, USP7 is involved in the regulation of stress…”
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Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection by Lavoisier, Alexandra, Schlaeppi, Jean-Marc

“…Therapeutic antibodies represent one of the fastest growing segments in the pharmaceutical market. They are used in a broad range of disease fields, such as…”
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Therapies directed at vascular endothelial growth factor by Manley, Paul W, Martiny-Baron, Georg, Schlaeppi, Jean-Marc, Wood, Jeanette M

“…The inhibition of angiogenesis through vascular endothelial growth factor (VEGF) receptor targeting is a strategy that is relatively tumour selective. The high…”
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Crystal Structure of the Human RORα Ligand Binding Domain in Complex with Cholesterol Sulfate at 2.2 Å by Kallen, Joerg, Schlaeppi, Jean-Marc, Bitsch, Francis, Delhon, Isabelle, Fournier, Brigitte

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Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors by Schlaeppi, J M, Wood, J M

“…Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is an important mediator of tumor-induced angiogenesis and represents a potential…”
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X-Ray Structure of the hRORα LBD at 1.63 Å: Structural and Functional Data that Cholesterol or a Cholesterol Derivative Is the Natural Ligand of RORα by Kallen, Joerg A., Schlaeppi, Jean-Marc, Bitsch, Francis, Geisse, Sabine, Geiser, Martin, Delhon, Isabelle, Fournier, Brigitte

“…The retinoic acid-related orphan receptor α (RORα) is an orphan member of the subfamily 1 of nuclear hormone receptors. No X-ray structure of RORα has been…”
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Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies by Holenstein, Fabian, Eriksson, Christer, Erlandsson, Ioana, Norrman, Nils, Simon, Jill, Danielsson, Åke, Milicov, Adriana, Schindler, Patrick, Schlaeppi, Jean-Marc

“…•Automated pre-capture filtration of unclarified mammalian cell-culture broths.•Staggered and parallel unattended multi-step processing of eight 1-L feeds in…”
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Exploring host-pathogen interactions through genome wide protein microarray analysis by Scietti, Luigi, Sampieri, Katia, Pinzuti, Irene, Bartolini, Erika, Benucci, Barbara, Liguori, Alessia, Haag, Andreas F., Lo Surdo, Paola, Pansegrau, Werner, Nardi-Dei, Vincenzo, Santini, Laura, Arora, Seguinde, Leber, Xavier, Rindi, Simonetta, Savino, Silvana, Costantino, Paolo, Maione, Domenico, Merola, Marcello, Speziale, Pietro, Bottomley, Matthew J., Bagnoli, Fabio, Masignani, Vega, Pizza, Mariagrazia, Scharenberg, Meike, Schlaeppi, Jean-Marc, Nissum, Mikkel, Liberatori, Sabrina

“…During bacterial pathogenesis extensive contacts between the human and the bacterial extracellular proteomes take place. The identification of novel…”
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Crystal Structure of Human Estrogen-related Receptor α in Complex with a Synthetic Inverse Agonist Reveals Its Novel Molecular Mechanism by Kallen, Joerg, Lattmann, Rene, Beerli, Rene, Blechschmidt, Anke, Blommers, Marcel J.J., Geiser, Martin, Ottl, Johannes, Schlaeppi, Jean-Marc, Strauss, Andre, Fournier, Brigitte

“…Inverse agonists of the constitutively active human estrogen-related receptorα (ERRα, NR3B1) are of potential interest for several disease indications (e.g…”
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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue by Chène, Patrick, Rudloff, Joëlle, Schoepfer, Joseph, Furet, Pascal, Meier, Peter, Qian, Zhiyan, Schlaeppi, Jean-Marc, Schmitz, Rita, Radimerski, Thomas

“…Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic…”
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Estrogen Receptor Modulators:  Identification and Structure−Activity Relationships of Potent ERα-Selective Tetrahydroisoquinoline Ligands by Renaud, Johanne, Bischoff, Serge François, Buhl, Thomas, Floersheim, Philipp, Fournier, Brigitte, Halleux, Christine, Kallen, Joerg, Keller, Hansjoerg, Schlaeppi, Jean-Marc, Stark, Wilhelm

“…As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), tetrahydroisoquinoline derivative 27 was discovered by high…”
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Identification of natural ligands of retinoic acid receptor-related orphan receptor α ligand-binding domain expressed in Sf9 cells––a mass spectrometry approach by Bitsch, Francis, Aichholz, Reiner, Kallen, Joerg, Geisse, Sabine, Fournier, Brigitte, Schlaeppi, Jean-Marc

“…The ligand-binding domain (LBD) of the human retinoic acid receptor-related orphan receptor (RORα-LBD), expressed in Sf9 cells, was purified and analyzed by…”
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Development of a Magnetic Particle-Based Automated Chemiluminescent Immunoassay for Triasulfuron by Schlaeppi, Jean-Marc A, Kessler, Anton, Foery, Werner

“…A fully automated immunoassay with high sample throughput for the quantitative analysis of triasulfuron in soil has been developed. The competitive assay was…”
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A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system by Schlaeppi, Jean-Marc, Henke, Mario, Mahnke, Marion, Hartmann, Steffen, Schmitz, Rita, Pouliquen, Yann, Kerins, Brendan, Weber, Eric, Kolbinger, Frank, Kocher, Hans P.

“…The efficient preparation of recombinant proteins at the lab-scale level is essential for drug discovery, in particular for structural biology, protein…”
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Improved expression of kinases in Baculovirus-infected insect cells upon addition of specific kinase inhibitors to the culture helpful for structural studies by Strauss, André, Fendrich, Gabriele, Horisberger, Michel André, Liebetanz, Janis, Meyhack, Bernd, Schlaeppi, Jean-Marc, Schmitz, Rita

“…As exemplified by three cases, we show that the addition of a small molecular weight inhibitor to the culture of Baculovirus-infected insect cells can…”
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1,25-DIHYDROXYVITAMIN D3 Induces the expression of vascular endothelial growth factor in osteoblastic cells by Schlaeppi, Jean-Marc, Gutzwiller, Sabine, Finkenzeller, Günter, Fournier, Brigitte

“…Angiogenesis is a fundamental process in skeletal development and repair, and previous studies indicate that vascular endothelial growth factor (VEGF), an…”
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Hydroxyatrazine and atrazine determination in soil and water by enzyme-linked immunosorbent assay using specific monoclonal antibodies by Schlaeppi, Jean Marc, Foery, Werner, Ramsteiner, Klaus

“…An immunoassay was developed for atrazine and hydroxyatrazine. Hybridoma technology was used to obtain monoclonal antibodies (MAB) against these compounds by…”
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Characterization of a new potent, in vivo neutralizing monoclonal antibody to human vascular endothelial growth factor by SCHLAEPPI, J.-M, SIEMEISTER, G, WEINDEL, K, SCHNELL, C, WOOD, J

“…Vascular endothelial growth factor (VEGF) is an important mediator of tumor-induced angiogenesis and represents a potential target for anticancer therapy…”
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Determination of triasulfuron in soil by monoclonal antibody-based enzyme immunoassay by Schlaeppi, Jean Marc A, Meyer, Willy, Ramsteiner, Klaus A

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Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis by Viloria-Petit, A, Crombet, T, Jothy, S, Hicklin, D, Bohlen, P, Schlaeppi, J M, Rak, J, Kerbel, R S

“…Inhibitors of epidermal growth factor receptor (EGFR) signaling are among the novel drugs showing great promise for cancer treatment in the clinic. However,…”
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