Search Results - "Jean Gabriel de Souza"

Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin by Iqbal, Asif, Goldfeder, Mauricio Barbugiani, Marques-Porto, Rafael, Asif, Huma, Souza, Jean Gabriel de, Faria, Fernanda, Chudzinski-Tavassi, Ana Marisa

“…Thrombin is a multifunctional enzyme with a key role in the coagulation cascade. Its functional modulation can culminate into normal blood coagulation or…”
Get full text

Comparative Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by Destabilization of Medial Meniscus by Dias de Oliveira, Felipe Bruno, Antonioli, Eliane, Dias, Olívia Furiama Metropolo, de Souza, Jean Gabriel, Agarwal, Sudha, Chudzinski-Tavassi, Ana Marisa, Ferretti, Mario

“…Transplanted mesenchymal stromal cells (MSCs) exhibit a robust anti-inflammatory and homing capacity in response to high inflammatory signals, as observed in…”
Get full text

Snake and arthropod venoms: Search for inflammatory activity in human cells involved in joint diseases by Alvarez-Flores, Miryam Paola, de Fatima Correia Batista, Isabel, Villas Boas, Isadora Maria, Bufalo, Michelle Cristiane, Gabriel de Souza, Jean, Oliveira, Douglas Souza, Bonfá, Giuliano, Fernandes, Cristina Maria, Porto, Rafael Marques, Lichtenstein, Flavio, Picolo, Gisele, Tambourgi, Denise V, Chudzinski-Tavassi, Ana Marisa, Martinez Ibañez, Olga Célia, Teixeira, Catarina

“…Most anti-inflammatory drugs currently adopted to treat chronic inflammatory joint diseases can alleviate symptoms but they do not lead to remission…”
Get full text

Tropism of mesenchymal stem cell toward CD133 + stem cell of glioblastoma in vitro and promote tumor proliferation in vivo by Pavon, Lorena Favaro, Sibov, Tatiana Tais, de Souza, Andrea Vieira, da Cruz, Edgar Ferreira, Malheiros, Suzana M F, Cabral, Francisco Romero, de Souza, Jean Gabriel, Boufleur, Pamela, de Oliveira, Daniela Mara, de Toledo, Silvia Regina Caminada, Marti, Luciana C, Malheiros, Jackeline Moraes, Paiva, Fernando F, Tannús, Alberto, de Oliveira, Sérgio Mascarenhas, Chudzinski-Tavassi, Ana Marisa, de Paiva Neto, Manoel A, Cavalheiro, Sérgio

“…Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for…”
Get full text

Seroepidemiological study of human cysticercosis with blood samples collected on filter paper, in Lages, State of Santa Catarina, Brazil, 2004-2005 by Ishida, Maria Márcia Imenes, Almeida, Marília Sirianni Dos Santos, Espíndola, Noeli Maria, Iha, Alberto, Pereira, Diana Ana, Souza, Jean Gabriel de, Varvakis, Theopi Rados, Vaz, Adelaide José

“…Human serofrequency of antibodies against Taenia solium antigens was determined and risk factors for cysticercosis transmission were identified. Individuals…”
Get full text

Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage by Oliveira, Douglas Souza, de Souza, Jean Gabriel, Alvarez-Flores, Miryam Paola, Cunegundes, Priscila S, DeOcesano-Pereira, Carlos, Lobba, Aline Maia, Gomes, Renata N, Chudzinski-Tavassi, Ana Marisa

“…Envenomation caused by contact with bristles is characterized by pain, an intense systemic proinflammatory reaction and disturbances in the coagulation cascade…”
Get full text

Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model by Lichtenstein, Flavio, Iqbal, Asif, de Lima Will, Sonia Elisabete Alves, Bosch, Rosemary Viola, DeOcesano-Pereira, Carlos, Goldfeder, Mauricio Barbugiani, Chammas, Roger, Trufen, Carlos Eduardo Madureira, Morais, Katia Luciano Pereira, de Souza, Jean Gabriel, Natalino, Renato Jose Mendonça, de Azevedo, Inacio Junqueira, Nishiyama Junior, Milton Yutaka, Oliveira, Ursula, Alves, Francisco Ivanio Arruda, Araujo, Jaqueline Mayara, Lobba, Aline Ramos Maia, Chudzinski-Tavassi, Ana Marisa

“…We have investigated Amblyomin-X-treated horse melanomas to better understand its mode of action through transcriptome analysis and the in vivo model…”
Get full text

Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production by Borrego, Andrea, Colombo, Francesca, de Souza, Jean Gabriel, Jensen, José Ricardo, Dassano, Alice, Piazza, Rocco, Rodrigues dos Santos, Barbara Anaís, Ribeiro, Orlando Garcia, De Franco, Marcelo, Cabrera, Wafa Hanna Koury, Icimoto, Marcelo Yudi, Starobinas, Nancy, Magalhães, Geraldo, Monteleone, Leticia Figueiredo, Eto, Silas Fernandes, DeOcesano-Pereira, Carlos, Goldfeder, Mauricio Barbugiani, Pasqualoto, Kerly Fernanda Mesquita, Dragani, Tommaso A., Ibañez, Olga Célia Martinez

“…We identified Pycard and BC017158 genes as putative effectors of the Quantitative Trait locus (QTL) that we mapped at distal chromosome 7 named Irm1 for…”
Get full text

Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke by Sibov, Tatiana Taís, Pavon, Lorena Favaro, Cabral, Francisco Romero, Cunha, Ivone Farias, de Oliveira, Daniela Mara, de Souza, Jean Gabriel, Marti, Luciana Cavalheiro, da Cruz, Edgar Ferreira, Malheiros, Jackeline Moraes, Paiva, Fernando F., Tannús, Alberto, de Oliveira, Sérgio Mascarenhas, da Costa, Marcos Devanir Silva, Dastoli, Patrícia A., Mendonça, Jardel N., de Toledo, Silvia Regina Caminada, Malheiros, Suzana M. Fleury, de Paiva Neto, Manoel Antonio, Rego, Nelma Bastos Bezerra, Moron, Antônio Fernandes, Cavalheiro, Sérgio

“…Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation of…”
Get full text

Establishment of primary cell culture and an intracranial xenograft model of pediatric ependymoma: a prospect for therapy development and understanding of tumor biology by Pavon, Lorena Favaro, Sibov, Tatiana Tais, Caminada de Toledo, Silvia Regina, Mara de Oliveira, Daniela, Cabral, Francisco Romero, Gabriel de Souza, Jean, Boufleur, Pamela, Marti, Luciana C, Malheiros, Jackeline Moraes, Ferreira da Cruz, Edgar, Paiva, Fernando F, Malheiros, Suzana M F, de Paiva Neto, Manoel A, Tannús, Alberto, Mascarenhas de Oliveira, Sérgio, Silva, Nasjla Saba, Cappellano, Andrea Maria, Petrilli, Antonio Sérgio, Chudzinski-Tavassi, Ana Marisa, Cavalheiro, Sérgio

“…Ependymoma (EPN), the third most common pediatric brain tumor, is a central nervous system (CNS) malignancy originating from the walls of the ventricular…”
Get full text

Unknown/enigmatic functions of extracellular ASC by Souza, Jean Gabriel, Starobinas, Nancy, Ibañez, Olga Celia Martinez

“…Apoptosis‐associated speck‐like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small molecule, which aggregates into…”
Get full text

A new differentiation method for THP-1-derived Dendritic Cells by Cunegundes, Priscila Silva, De Souza, Jean Gabriel, Oliveira, Douglas Souza, Chudzinski-Tavassi, Ana Marisa

Get full text

Lonomia Obliqua crude bristle extract induce NFkB translocation in THP-1 macrophage by Oliveira, Douglas Souza, Francelin, Helena, De Souza, Jean Gabriel, Alvarez Flores, Miryam Paola, Chudzinski-Tavassi, Ana Marisa

Get full text

Effect of protein rLOPAP and peptide derived on human chondrocytes in the inflammatory model with interleucin-1β by Pazelli, Gabriela Simões, Alvarez Flores, Miryam Paola, De Ocesano Pereira, Carlos, De Souza, Jean Gabriel, Chudzinski-Tavassi, Ana Marisa

Get full text

Centre of Excellence in New Target Discovery: a Biobank establishment by Fátima Correia Batista, Isabel de, Trufen, Carlos Eduardo Madureira, Souza, Jean Gabriel de, Marques-Porto, Rafael, Portas, Viviane Barbosa, Jared, Carlos, Chudzinski-Tavassi, Ana Marisa

Get full text

Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates by Chudzinski-Tavassi, Ana Marisa, Morais, Katia L.P, Pacheco, Mário Thiego Fernandes, Pasqualoto, Kerly Fernanda Mesquita, de Souza, Jean Gabriel

“…Abstract Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has…”
Get full text

New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X by Pavon, Lorena Favaro, Capper, David, Sibov, Tatiana Tais, de Toledo, Silvia Regina Caminada, Thomale, Ulrich-W., de Souza, Jean Gabriel, Cabral, Francisco Romero, Berra, Carolina Maria, Silva da Costa, Marcos Devanir, Mendonça Niçacio, Jardel, Dastoli, Patrícia Alessandra, de Oliveira, Daniela Mara, Malheiros, Suzana M. F., da Cruz, Edgar Ferreira, Malheiros, Jackeline Moraes, de Oliveira, Sérgio Mascarenhas, Silva, Nasjla Saba, Petrilli, Antonio Sérgio, Cappellano, Andrea Maria, Brunialti, Milena Colò, Salomão, Reinaldo, de Paiva Neto, Manoel A., Chudzinski-Tavassi, Ana Marisa, Cavalheiro, Sérgio

“…EPNs comprise a heterogeneous group of neuroepithelial tumors, accounting for about 10% of all intracranial tumors in children and up to 30% of brain tumors in…”
Get full text

Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model by de Souza, Jean Gabriel, Morais, Katia L.P., Anglés-Cano, Eduardo, Boufleur, Pamela, de Mello, Evandro Sobroza, Maria, Durvanei Augusto, Origassa, Clarice Silvia Taemi, de Campos Zampolli, Hamilton, Câmara, Niels Olsen Saraiva, Berra, Carolina Maria, Bosch, Rosemary Viola, Chudzinski-Tavassi, Ana Marisa

“…Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly resistant to current treatments. It has been previously reported that…”
Get full text

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production by Maria, Durvanei Augusto, de Souza, Jean Gabriel, Morais, Katia L. P., Berra, Carolina Maria, Zampolli, Hamilton de Campos, Demasi, Marilene, Simons, Simone Michaela, de Freitas Saito, Renata, Chammas, Roger, Chudzinski-Tavassi, Ana Marisa

“…Summary In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2…”
Get full text

Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells by Pavon, Lorena Favaro, Sibov, Tatiana Tais, de Oliveira, Daniela Mara, Marti, Luciana C, Cabral, Francisco Romero, de Souza, Jean Gabriel, Boufleur, Pamela, Malheiros, Suzana M F, de Paiva Neto, Manuel A, da Cruz, Edgard Ferreira, Chudzinski-Tavassi, Ana Marisa, Cavalheiro, Sérgio

“…Glioblastoma is composed of dividing tumor cells, stromal cells and tumor initiating CD133+ cells. Recent reports have discussed the origin of the glioblastoma…”
Get full text