Search Results - "Jean Delisle"

TGF-β in T Cell Biology: Implications for Cancer Immunotherapy by Dahmani, Amina, Delisle, Jean-Sébastien

“…Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large amounts within cancer microenvironments that will ultimately promote…”
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CD5 levels define functionally heterogeneous populations of naïve human CD4+ T cells by Sood, Aditi, Lebel, Marie‐Ève, Dong, Mengqi, Fournier, Marilaine, Vobecky, Suzanne J., Haddad, Élie, Delisle, Jean‐Sébastien, Mandl, Judith N., Vrisekoop, Nienke, Melichar, Heather J.

“…Studies in murine models show that subthreshold TCR interactions with self‐peptide are required for thymic development and peripheral survival of naïve T…”
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baredSC: Bayesian approach to retrieve expression distribution of single-cell data by Lopez-Delisle, Lucille, Delisle, Jean-Baptiste

“…The number of studies using single-cell RNA sequencing (scRNA-seq) is constantly growing. This powerful technique provides a sampling of the whole…”
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T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies by Janelle, Valérie, Delisle, Jean-Sébastien

“…Over the last decades, cellular immunotherapy has revealed its curative potential. However, inherent physiological characteristics of immune cells can limit…”
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BK Polyomavirus and the Transplanted Kidney: Immunopathology and Therapeutic Approaches by Lamarche, Caroline, Orio, Julie, Collette, Suzon, Senécal, Lynne, Hébert, Marie-Josée, Renoult, Édith, Tibbles, Lee Anne, Delisle, Jean-Sébastien

“…ABSTRACTBK polyomavirus is ubiquitous, with a seropositivity rate of over 75% in the adult population. Primary infection is thought to occur in the respiratory…”
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T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies by Janelle, Valérie, Rulleau, Caroline, Del Testa, Simon, Carli, Cédric, Delisle, Jean-Sébastien

“…Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell…”
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Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes by Ehx, Grégory, Larouche, Jean-David, Durette, Chantal, Laverdure, Jean-Philippe, Hesnard, Leslie, Vincent, Krystel, Hardy, Marie-Pierre, Thériault, Catherine, Rulleau, Caroline, Lanoix, Joël, Bonneil, Eric, Feghaly, Albert, Apavaloaei, Anca, Noronha, Nandita, Laumont, Céline M., Delisle, Jean-Sébastien, Vago, Luca, Hébert, Josée, Sauvageau, Guy, Lemieux, Sébastien, Thibault, Pierre, Perreault, Claude

“…Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Using an original…”
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Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study by Cohen, Sandra, Roy, Jean, Lachance, Silvy, Delisle, Jean-Sébastien, Marinier, Anne, Busque, Lambert, Roy, Denis-Claude, Barabé, Frédéric, Ahmad, Imran, Bambace, Nadia, Bernard, Léa, Kiss, Thomas, Bouchard, Philippe, Caudrelier, Pierre, Landais, Sévérine, Larochelle, Fannie, Chagraoui, Jalila, Lehnertz, Bernhard, Corneau, Sophie, Tomellini, Elisa, van Kampen, Jeroen J A, Cornelissen, Jan J, Dumont-Lagacé, Maude, Tanguay, Mégane, Li, Qi, Lemieux, Sébastien, Zandstra, Peter W, Sauvageau, Guy

“…Benefits of cord blood transplantation include low rates of relapse and chronic graft-versus-host disease (GVHD). However, the use of cord blood is rapidly…”
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Leukoreduction system chambers are a reliable cellular source for the manufacturing of T‐cell therapeutics by Boudreau, Gabrielle, Carli, Cédric, Lamarche, Caroline, Rulleau, Caroline, Bonnaure, Guillaume, Néron, Sonia, Delisle, Jean‐Sébastien

“…BACKGROUND Following solid organ or hematopoietic cell transplantation, refractory opportunistic viral reactivations are a significant cause of morbidity and…”
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Allodepleted T‐cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft‐versus‐host disease (GVHD) in the absence of GVHD prophylaxis by Roy, Denis Claude, Lachance, Sylvie, Cohen, Sandra, Delisle, Jean‐Sébastien, Kiss, Thomas, Sauvageau, Guy, Busque, Lambert, Ahmad, Imran, Bernard, Lea, Bambace, Nadia, Boumédine, Radia S., Guertin, Marie‐Claude, Rezvani, Katayoun, Mielke, Stephan, Perreault, Claude, Roy, Jean

“…Summary Graft‐versus‐host disease (GVHD) is a major cause of transplant‐related mortality (TRM) after allogeneic haematopoietic stem cell transplantation…”
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Immature and mature bone marrow-derived dendritic cells exhibit distinct intracellular mechanical properties by Leblanc-Hotte, Antoine, Audiger, Cindy, Chabot-Roy, Geneviève, Lombard-Vadnais, Félix, Delisle, Jean-Sébastien, Peter, Yves-Alain, Lesage, Sylvie

“…Dendritic cells (DCs) patrol the organism at an immature stage to detect the presence of pathogens. Once activated, these mature DCs reach the lymph nodes to…”
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Carboplatin and vincristine neurotoxicity in the treatment of pediatric low‐grade gliomas by Rosca, Lorena, Robert‐Boire, Viviane, Delisle, Jean‐François, Samson, Yvan, Perreault, Sébastien

“…Background Pediatric low‐grade gliomas (LGG) represent 30‐50% of central nervous system pediatric tumors. Over the last decades, the combination of carboplatin…”
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Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment by Serroukh, Yasmina, Hébert, Josée, Busque, Lambert, Mercier, François, Rudd, Christopher E., Assouline, Sarit, Lachance, Silvy, Delisle, Jean-Sébastien

“…Acute myeloid leukemia (AML) is a cancer that originates from the bone marrow (BM). Under physiological conditions, the bone marrow supports the homeostasis of…”
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Armstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure by Caron, Laurence, Delisle, Jean-Sébastien, Strong, James E, Deschambault, Yvon, Lombard-Vadnais, Félix, Labbé, Annie-Claude, Lesage, Sylvie

“…Lymphocytic choriomeningitis virus (LCMV) is a human pathogen naturally present in wild rodents. In addition, LCMV is routinely used in immunology research as…”
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Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy by Lamarche, Caroline, Orio, Julie, Georges-Tobar, Victoria, Pincez, Thomas, Goupil, Mathieu, Dahmani, Amina, Carli, Cedric, Brasey, Ann, Busque, Lambert, Delisle, Jean-Sébastien

“…BACKGROUNDPolyomavirus-associated nephropathy (PVAN) after BK virus reactivation in kidney transplant recipients (KTR) can compromise graft survival. Lowering…”
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Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk by Dejda, Agnieszka, Mawambo, Gaelle, Cerani, Agustin, Miloudi, Khalil, Shao, Zhuo, Daudelin, Jean-Francois, Boulet, Salix, Oubaha, Malika, Beaudoin, Felix, Akla, Naoufal, Henriques, Sullivan, Menard, Catherine, Stahl, Andreas, Delisle, Jean-Sébastien, Rezende, Flavio A, Labrecque, Nathalie, Sapieha, Przemyslaw

“…Immunological activity in the CNS is largely dependent on an innate immune response and is heightened in diseases, such as diabetic retinopathy, multiple…”
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Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation by Andriessen, Elisabeth M M A, Binet, François, Fournier, Frédérik, Hata, Masayuki, Dejda, Agnieszka, Mawambo, Gaëlle, Crespo‐Garcia, Sergio, Pilon, Frédérique, Buscarlet, Manuel, Beauchemin, Karine, Bougie, Véronique, Cumberlidge, Garth, Wilson, Ariel M, Bourgault, Steve, Rezende, Flavio A, Beaulieu, Normand, Delisle, Jean‐Sébastien, Sapieha, Przemyslaw

“…Age‐related macular degeneration (AMD) in its various forms is a leading cause of blindness in industrialized countries. Here, we provide evidence that ligands…”
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VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation by Oussa, Nougboli A E, Dahmani, Amina, Gomis, Marie, Richaud, Manon, Andreev, Emil, Navab-Daneshmand, Ali-Reza, Taillefer, Julie, Carli, Cédric, Boulet, Salix, Sabbagh, Laurent, Labrecque, Nathalie, Sapieha, Przemyslaw, Delisle, Jean-Sébastien

“…To stimulate a productive T cell response, dendritic cells (DC) must undergo maturation characterized by heightened cell surface expression of MHC and…”
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Early free light chain reduction following treatment initiation predicts favorable outcome in intact immunoglobulin myeloma by Claveau, Jean-Sébastien, Savary Bélanger, Sophie, Ahmad, Imran, Delisle, Jean-Sébastien, De Guire, Vincent, Roy, Jean, LeBlanc, Richard

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Safety and Immunogenicity After a Three-Dose SARS-CoV-2 Vaccine Schedule in Allogeneic Stem Cell Transplant Recipients by Kimura, Muneyoshi, Ferreira, Victor H., Kothari, Sagar, Pasic, Ivan, Mattsson, Jonas I., Kulasingam, Vathany, Humar, Atul, Mah, Allison, Delisle, Jean-Sébastien, Ierullo, Matthew, Majchrzak-Kita, Beata, Kumar, Deepali, Hosseini-Moghaddam, Seyed M.

“…In allogeneic stem cell transplant (Allo-SCT) recipients, the cell-mediated and humoral immunogenicity of the 3-dose SARS-CoV-2 vaccination schedule has not…”
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