Search Results - "Jean‐Philippe, Merlio"

Staphylococcus aureus and Sézary syndrome by Merlio, Jean-Philippe

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Performances of the Idylla GeneFusion Assay: contribution to a rapid diagnosis of targetable gene fusions in tumour samples by Guillard, Matthieu, Caumont, Charline, Marcorelles, Pascale, Merlio, Jean-Philippe, Cappellen, David, Uguen, Arnaud

“…We aimed to evaluate the performances of the Idylla GeneFusion Assay (IGFA) designed to detect, in a single, rapid and fully automated assay, , , , , and gene…”
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Circulating Tumor Cell Clusters: United We Stand Divided We Fall by Amintas, Samuel, Bedel, Aurélie, Moreau-Gaudry, François, Boutin, Julian, Buscail, Louis, Merlio, Jean-Philippe, Vendrely, Véronique, Dabernat, Sandrine, Buscail, Etienne

“…The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive…”
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Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity by Poglio, Sandrine, Prochazkova-Carlotti, Martina, Cherrier, Floriane, Gros, Audrey, Laharanne, Elodie, Pham-Ledard, Anne, Beylot-Barry, Marie, Merlio, Jean-Philippe

“…Sézary Syndrome (SS) is a rare aggressive epidermotropic cutaneous T-cell lymphoma (CTCL) defined by erythroderma, pruritis, and a circulating atypical CD4 +…”
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MSI-High RAS-BRAF wild-type colorectal adenocarcinomas with MLH1 loss have a high frequency of targetable oncogenic gene fusions whose diagnoses are feasible using methods easy-to-implement in pathology laboratories by Bocciarelli, Claire, Caumont, Charline, Samaison, Laura, Cariou, Mélanie, Aline-Fardin, Aude, Doucet, Laurent, Roudié, Jean, Terris, Benoît, Merlio, Jean-Philippe, Marcorelles, Pascale, Cappellen, David, Uguen, Arnaud

“…Targetable kinase fusions are extremely rare (<1%) in colorectal cancers (CRCs), making their diagnosis challenging and often underinvestigated. They have been…”
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Identification of Somatic Mutations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type by Massive Parallel Sequencing by Mareschal, Sylvain, Pham-Ledard, Anne, Viailly, Pierre Julien, Dubois, Sydney, Bertrand, Philippe, Maingonnat, Catherine, Fontanilles, Maxime, Bohers, Elodie, Ruminy, Philippe, Tournier, Isabelle, Courville, Philippe, Lenormand, Bernard, Duval, Anne Bénédicte, Andrieu, Emilie, Verneuil, Laurence, Vergier, Beatrice, Tilly, Hervé, Joly, Pascal, Frebourg, Thierry, Beylot-Barry, Marie, Merlio, Jean-Philippe, Jardin, Fabrice

“…To determine whether the mutational profile of primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT) is unique by comparison with other diffuse…”
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High frequency and clinical prognostic value of MYD88 L265P mutation in primary cutaneous diffuse large B-cell lymphoma, leg-type by Pham-Ledard, Anne, Beylot-Barry, Marie, Barbe, Coralie, Leduc, Marion, Petrella, Tony, Vergier, Béatrice, Martinez, Fabian, Cappellen, David, Merlio, Jean-Philippe, Grange, Florent

“…The activating mutation of MYD88 L265P is a frequent feature of primary cutaneous diffuse large B-cell lymphoma, leg-type (PCLBCL-LT), reported in up to 69% of…”
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Diagnosis and treatment of lymphomas in the era of epigenetics by Chebly, Alain, Chouery, Eliane, Ropio, Joana, Kourie, Hampig Raphael, Beylot-Barry, Marie, Merlio, Jean-Philippe, Tomb, Roland, Chevret, Edith

“…Lymphomas represent a heterogeneous group of cancers characterized by clonal lymphoproliferation. Over the past decades, frequent epigenetic dysregulations…”
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Cytokines, Genetic Lesions and Signaling Pathways in Anaplastic Large Cell Lymphomas by Merlio, Jean-Philippe, Kadin, Marshall E.

“…ALCL is a tumor of activated T cells and possibly innate lymphoid cells with several subtypes according to clinical presentation and genetic lesions. On one…”
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Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohistochemical and molecular testing by Boursault, Lucile, Haddad, Véronique, Vergier, Béatrice, Cappellen, David, Verdon, Severine, Bellocq, Jean-Pierre, Jouary, Thomas, Merlio, Jean-Philippe

“…BRAF inhibitors have demonstrated improvement of overall survival in patients with metastatic melanoma and BRAF(V600) mutations. In order to evaluate BRAF…”
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Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances by Cabillic, Florian, Gros, Audrey, Dugay, Frédéric, Begueret, Hugues, Mesturoux, Laura, Chiforeanu, Dan Cristian, Dufrenot, Leila, Jauffret, Vincent, Dachary, Dominique, Corre, Romain, Lespagnol, Alexandra, Soler, Gwendoline, Dagher, Julien, Catros, Véronique, Le Calve, Michèle, Merlio, Jean-Philippe, Belaud-Rotureau, Marc-Antoine

“…Anaplastic lymphoma kinase (ALK) rearrangements occur in 1% to 7% of non-small-cell lung cancers (NSCLCs). Crizotinib, an ALK inhibitor, has been demonstrated…”
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Exploring hTERT promoter methylation in cutaneous T‐cell lymphomas by Chebly, Alain, Ropio, Joana, Peloponese, Jean‐Marie, Poglio, Sandrine, Prochazkova‐Carlotti, Martina, Cherrier, Floriane, Ferrer, Jacky, Idrissi, Yamina, Segal‐Bendirdjian, Evelyne, Chouery, Eliane, Farra, Chantal, Pham‐Ledard, Anne, Beylot‐Barry, Marie, Merlio, Jean‐Philippe, Tomb, Roland, Chevret, Edith

“…Cutaneous T‐cell lymphomas (CTCLs) are telomerase‐positive tumors expressing hTERT, although neither gene rearrangement/amplification nor promoter hotspot…”
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Integrative diagnosis of primary cutaneous large B-cell lymphomas supports the relevance of cell of origin profiling by Gros, Audrey, Menguy, Sarah, Bobée, Victor, Ducharme, Océane, Cassaigne, Isabelle Cirilo, Vergier, Béatrice, Parrens, Marie, Beylot-Barry, Marie, Pham-Ledard, Anne, Ruminy, Philippe, Jardin, Fabrice, Merlio, Jean-Philippe

“…Primary cutaneous large B-cell lymphomas (PCLBCL) represent a diagnostic challenge because they are classified as PCLBCL, leg type (PCLBCL, LT) or primary…”
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PD-L1 and PD-L2 Are Differentially Expressed by Macrophages or Tumor Cells in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type by Menguy, Sarah, Prochazkova-Carlotti, Martina, Beylot-Barry, Marie, Saltel, Fréderic, Vergier, Béatrice, Merlio, Jean-Philippe, Pham-Ledard, Anne

“…As checkpoint molecules' inhibition may represent a therapeutic option in relapsing cases, we assessed programmed death ligands' (PD-L1/PD-L2) expression in a…”
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MYD88 Somatic Mutation Is a Genetic Feature of Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type by Pham-Ledard, Anne, Cappellen, David, Martinez, Fabian, Vergier, Béatrice, Beylot-Barry, Marie, Merlio, Jean-Philippe

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Primary cutaneous large B‐cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases by Menguy, Sarah, Beylot‐Barry, Marie, Parrens, Marie, Ledard, Anne‐Pham, Frison, Eric, Comoz, François, Battistella, Maxime, Szablewski, Vanessa, Balme, Brigitte, Croue, Anne, Franck, Frédéric, Ortonne, Nicolas, Tournier, Emilie, Lamant, Laurence, Carlotti, Agnès, De Muret, Anne, Le Gall, François, Lorton, Marie‐Hélène, Merlio, Jean‐Philippe, Vergier, Béatrice

“…Aims We applied the 2017 World Health Organization (WHO) classification criteria to categorise a series of 64 primary cutaneous large B‐cell lymphomas…”
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Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas by Menguy, Sarah, Frison, Eric, Prochazkova-Carlotti, Martina, Dalle, Stephane, Dereure, Olivier, Boulinguez, Serge, Dalac, Sophie, Machet, Laurent, Ram-Wolff, Caroline, Verneuil, Laurence, Gros, Audrey, Vergier, Béatrice, Beylot-Barry, Marie, Merlio, Jean-Philippe, Pham-Ledard, Anne

“…In nodal diffuse large B-cell lymphoma, the search for double-hit with MYC and BCL2 and/or BCL6 rearrangements or for dual expression of BCL2 and MYC defines…”
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Reliable blood cancer cells' telomere length evaluation by qPCR by Ropio, Joana, Chebly, Alain, Ferrer, Jacky, Prochazkova‐Carlotti, Martina, Idrissi, Yamina, Azzi‐Martin, Lamia, Cappellen, David, Pham‐Ledard, Anne, Soares, Paula, Merlio, Jean‐Philippe, Chevret, Edith

“…Background Telomere shortening is linked to a range of different human diseases, hence reliable measurement methods are needed to uncover such associations…”
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Telomeric Repeat-Containing RNA (TERRA): A Review of the Literature and First Assessment in Cutaneous T-Cell Lymphomas by Chebly, Alain, Ropio, Joana, Baldasseroni, Lyla, Prochazkova-Carlotti, Martina, Idrissi, Yamina, Ferrer, Jacky, Farra, Chantal, Beylot-Barry, Marie, Merlio, Jean-Philippe, Chevret, Edith

“…Telomeric Repeat-containing RNA (TERRA) are long non-coding RNAs transcribed from telomeric DNA sequences from multiple chromosome ends. Major research efforts…”
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EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR wild-type pre-treated advanced nonsmall cell lung cancer in daily practice by Tomasini, Pascale, Brosseau, Solenn, Mazières, Julien, Merlio, Jean-Philippe, Beau-Faller, Michèle, Mosser, Jean, Wislez, Marie, Ouafik, L'Houcine, Besse, Benjamin, Rouquette, Isabelle, Debieuvre, Didier, Escande, Fabienne, Westeel, Virginie, Audigier-Valette, Clarisse, Missy, Pascale, Langlais, Alexandra, Morin, Frank, Moro-Sibilot, Denis, Zalcman, Gérard, Barlesi, Fabrice

“…Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are approved for second-line treatment of wild-type ( -wt) nonsmall cell lung cancer…”
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