Search Results - "Jean, Y"

The Capable ABL: What Is Its Biological Function? by Wang, Jean Y. J.

“…The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA…”
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Benchmarking clustering algorithms on estimating the number of cell types from single-cell RNA-sequencing data by Yu, Lijia, Cao, Yue, Yang, Jean Y H, Yang, Pengyi

“…A key task in single-cell RNA-seq (scRNA-seq) data analysis is to accurately detect the number of cell types in the sample, which can be critical for…”
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Staphylococcus aureus host interactions and adaptation by Howden, Benjamin P., Giulieri, Stefano G., Wong Fok Lung, Tania, Baines, Sarah L., Sharkey, Liam K., Lee, Jean Y. H., Hachani, Abderrahman, Monk, Ian R., Stinear, Timothy P.

“…Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S…”
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Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses in the US, 2010-2017 by Hirai, Ashley H, Ko, Jean Y, Owens, Pamela L, Stocks, Carol, Patrick, Stephen W

“…IMPORTANCE: Substantial increases in both neonatal abstinence syndrome (NAS) and maternal opioid use disorder have been observed through 2014. OBJECTIVE: To…”
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Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition by Lee, Jenny H., Shklovskaya, Elena, Lim, Su Yin, Carlino, Matteo S., Menzies, Alexander M., Stewart, Ashleigh, Pedersen, Bernadette, Irvine, Malama, Alavi, Sara, Yang, Jean Y. H., Strbenac, Dario, Saw, Robyn P. M., Thompson, John F., Wilmott, James S., Scolyer, Richard A., Long, Georgina V., Kefford, Richard F., Rizos, Helen

“…Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated. We now show that…”
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DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs by Li, Manqing, Kao, Elaine, Malone, Dane, Gao, Xia, Wang, Jean Y. J., David, Michael

“…Transcriptome analysis reveals a strong positive correlation between human Schlafen family member 11 (SLFN11) expression and the sensitivity of tumor cells to…”
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Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma by Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., Li, Jiang R., Kim, Geurim, Rezaee, Melika, Ally, Mina S., Kim, Jinah, Yao, Catherine, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y.

“…Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations…”
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3D reconstruction of spatial expression by Lin, Yingxin, Yang, Jean Y. H.

“…A novel approach to probabilistically align adjacent multiple tissue slices from spatially resolved transcriptomics data provides unprecedented depth for the…”
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scJoint integrates atlas-scale single-cell RNA-seq and ATAC-seq data with transfer learning by Lin, Yingxin, Wu, Tung-Yu, Wan, Sheng, Yang, Jean Y. H., Wong, Wing H., Wang, Y. X. Rachel

“…Single-cell multiomics data continues to grow at an unprecedented pace. Although several methods have demonstrated promising results in integrating several…”
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Atlas-scale single-cell multi-sample multi-condition data integration using scMerge2 by Lin, Yingxin, Cao, Yue, Willie, Elijah, Patrick, Ellis, Yang, Jean Y. H.

“…The recent emergence of multi-sample multi-condition single-cell multi-cohort studies allows researchers to investigate different cell states. The effective…”
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Scalable workflow for characterization of cell-cell communication in COVID-19 patients by Lin, Yingxin, Loo, Lipin, Tran, Andy, Lin, David M, Moreno, Cesar, Hesselson, Daniel, Neely, G Gregory, Yang, Jean Y H

“…COVID-19 patients display a wide range of disease severity, ranging from asymptomatic to critical symptoms with high mortality risk. Our ability to understand…”
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Gene Therapy for Epidermolysis Bullosa by Marinkovich, M. Peter, Tang, Jean Y.

“…Epidermolysis bullosa is a family of diseases characterized by blistering and fragility of the skin in response to mechanical trauma. Advances in our…”
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Targeting the RB-pathway in Cancer Therapy by KNUDSEN, Erik S, WANG, Jean Y. J

“…The RB-pathway, consisting of inhibitors and activators of cyclin-dependent kinases, the retinoblastoma tumor suppressor (RB), and the E2F-family of…”
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Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis by Geddes, Thomas A, Kim, Taiyun, Nan, Lihao, Burchfield, James G, Yang, Jean Y H, Tao, Dacheng, Yang, Pengyi

“…Single-cell RNA-sequencing (scRNA-seq) is a transformative technology, allowing global transcriptomes of individual cells to be profiled with high accuracy. An…”
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Prevalence and patterns of marijuana use among pregnant and nonpregnant women of reproductive age by Ko, Jean Y., PhD, Farr, Sherry L., PhD, Tong, Van T., MPH, Creanga, Andreea A., MD, PhD, Callaghan, William M., MD, MPH

“…Objective The objective of the study was to provide national prevalence, patterns, and correlates of marijuana use in the past month and past 2–12 months among…”
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BIDCell: Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data by Fu, Xiaohang, Lin, Yingxin, Lin, David M., Mechtersheimer, Daniel, Wang, Chuhan, Ameen, Farhan, Ghazanfar, Shila, Patrick, Ellis, Kim, Jinman, Yang, Jean Y. H.

“…Recent advances in subcellular imaging transcriptomics platforms have enabled high-resolution spatial mapping of gene expression, while also introducing…”
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Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2 by Humphrey, Sean J., Yang, Guang, Yang, Pengyi, Fazakerley, Daniel J., Stöckli, Jacqueline, Yang, Jean Y., James, David E.

“…A major challenge of the post-genomics era is to define the connectivity of protein phosphorylation networks. Here, we quantitatively delineate the insulin…”
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Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma by KIM, Daniel J, KIM, James, TANG, Jean Y, SPAUNHURST, Katrina, MONTOYA, Javier, KHODOSH, Rita, CHANDRA, Kalyani, FU, Teresa, GILLIAM, Anita, MOLGO, Monserrat, BEACHY, Philip A

“…Itraconazole, a US Food and Drug Administration-approved antifungal drug, inhibits the Hedgehog (HH) signaling pathway, a crucial driver of basal cell…”
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A gene regulatory network for root epidermis cell differentiation in Arabidopsis by Bruex, Angela, Kainkaryam, Raghunandan M, Wieckowski, Yana, Kang, Yeon Hee, Bernhardt, Christine, Xia, Yang, Zheng, Xiaohua, Wang, Jean Y, Lee, Myeong Min, Benfey, Philip, Woolf, Peter J, Schiefelbein, John

“…The root epidermis of Arabidopsis provides an exceptional model for studying the molecular basis of cell fate and differentiation. To obtain a systems-level…”
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Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions by Baleriola, Jimena, Walker, Chandler A., Jean, Ying Y., Crary, John F., Troy, Carol M., Nagy, Peter L., Hengst, Ulrich

“…In Alzheimer’s disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire…”
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