Microencapsulation of benzalkonium chloride enhanced its antibacterial and antibiofilm activities against Listeria monocytogenes and Escherichia coli

Microencapsulation of benzalkonium chloride enhanced its antibacterial and antibiofilm activities against Listeria monocytogenes and Escherichia coli

Aims In this study, benzalkonium chloride (BAC) microcapsules were developed for surface disinfection purpose and were evaluated against Listeria monocytogenes and Escherichia coli biofilms. Methods and Results Microcapsules were prepared with two different strategies: uncomplexed BAC‐microcapsules...

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Bibliographic Details
Published in:Journal of applied microbiology Vol. 131; no. 3; pp. 1136 - 1146
Main Authors: Khelissa, S., Gharsallaoui, A., Fadel, A., Barras, A., Jama, C., Jbilou, F., Chihib, N.‐E.
Format: Journal Article
Language:English
Published: England Oxford University Press 01-09-2021
Wiley
Subjects:
Antibacterial activity
antibiofilm activity
Bacteriology
Benzalkonium chloride
Biofilms
Chlorides
Cytotoxicity
Disinfection
E coli
Escherichia coli
Food engineering
Food irradiation
Free form
Life Sciences
Listeria
Listeria monocytogenes
Microbiology and Parasitology
Microcapsules
Microencapsulation
Pectin
Stainless steel
Stainless steels
Toxicity
Listeria monocytogenes
benzalkonium chloride
Escherichia coli
microencapsulation
antibiofilm activity
Benzalkonium chloride
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Summary:Aims In this study, benzalkonium chloride (BAC) microcapsules were developed for surface disinfection purpose and were evaluated against Listeria monocytogenes and Escherichia coli biofilms. Methods and Results Microcapsules were prepared with two different strategies: uncomplexed BAC‐microcapsules (UBM) containing BAC and maltodextrins, and complexed BAC‐microcapsules (CBM) containing BAC complexed by pectin and maltodextrins. The minimum inhibitory concentrations (MICs) of free and microencapsulated BAC were investigated against two food pathogens: L. monocytogenes and E. coli. The antibiofilm activities of UBM and CBM against L. monocytogenes and E. coli biofilms formed on stainless steel at 37°C were evaluated and compared to BAC used under its free form. MICs of encapsulated BAC were up to fourfold lower than those of free BAC. The UBM and CBM showed higher antibiofilm effect when compared to the free BAC. Conclusions Overall, results demonstrated that microencapsulation enhanced the antibacterial activity of BAC against L. monocytogenes and E. coli biofilms. Significance and Impact of the Study The application of such BAC microcapsule‐based delivery systems can improve surface disinfection procedures and reduce the required BAC concentrations and the related cytotoxicity of this antimicrobial compound.
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ISSN:1364-5072
1365-2672
DOI:10.1111/jam.15010