Search Results - "Jaynes, Burton H"

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog by Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-lyl]-5-methanesulfonyl (SO 2Me)/5-sulfamoyl (SO 2NH…”
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Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents:  In Vitro and in Vivo Potency against Pasteurella multocida by McFarland, James W, Berger, Cynthia M, Froshauer, Susan A, Hayashi, Shigeru F, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Kamicker, Barbara J, Lipinski, Christopher A, Lundy, Kristin M, Reese, Catherine P, Vu, Chi B

“…Quantitative structure−activity relationships have been found among macrolide antibacterial agents in their potencies against the bacterial pathogen…”
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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile by Sakya, Subas M., Hou, Xinjun, Minich, Martha L., Rast, Bryson, Shavnya, Andrei, DeMello, Kristin M.L., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L.

“…The SAR of the 5-heteroatom and aryl substituted pyrazoles with 4-nitrile substitution shows substantial improvement in activity against the COX enzymes…”
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Comparative structure–activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition by Sakya, Subas M., Shavnya, Andrei, Cheng, Hengmiao, Li, Chao, Rast, Bryson, Li, Jin, Koss, David A., Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship (SAR) studies of novel 5-alkyl and 5-aryl/heteroaryl substituted 1,2,4-triazoles are described. The in vitro activity is…”
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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors by Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.

“…The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure–activity relationship (SAR)…”
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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers by Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine…”
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In vitro and in vivo profile of 5-[(4' -trifluoromethyl -biphenyl -2-carbonyl ) -amino]-1H -indole -2 -carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity by JIN LI, BRONK, Brian S, HAVEN, Michelle L, KOLOSKO, Nicole L, BARRY, Chris J, MANION, Tara B, DIRLAM, John P, BLIZE, Alan E, BERTINATO, Peter, JAYNES, Burton H, HICKMAN, Anne, MISKELL, Christine, PILLAI, Usha A, TIBBITTS, Jay S

“…The synthesis of a novel gut selective MTP inhibitor, 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl…”
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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine by Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette

“…Structure–activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes…”
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Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents by Li, Jin, Bertinato, Peter, Cheng, Hengmiao, Cole, Bridget M., Bronk, Brian S., Jaynes, Burton H., Hickman, Anne, Haven, Michelle L., Kolosko, Nicole L., Barry, Chris J., Manion, Tara B.

“…Structure activity relationship (SAR) studies of a novel class of MTP inhibitors are described. A number of novel MTP inhibitors have been identified with…”
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Efficient Preparation of Hygromycin A Aglycon and Its Antibacterial 4'-Allyl Ether, CP-111905 by Jaynes, Burton H, Elliott, Nancy C, Jefson, Martin R, Koss, David A, Schicho, Douglas L

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In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor by Li, Jin, Lynch, Michael P., DeMello, Kristin Lundy, Sakya, Subas M., Cheng, Hengmiao, Rafka, Robert J., Bronk, Brian S., Jaynes, Burton H., Kilroy, Carolyn, Mann, Donald W., Haven, Michelle L., Kolosko, Nicole L., Petras, Carol, Seibel, Scott B., Lund, Lisa A.

“…The synthesis of a novel canine COX-2 selective inhibitor, 2-(3-difluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, and its in vitro and in vivo…”
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A synthetic route to forskolin by Ziegler, Frederick E, Jaynes, Burton H, Saindane, Manohar T

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Repromicin Derivatives with Potent Antibacterial Activity against Pasteurella multocida by McFarland, James W, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Lundy, Kristin M, Vu, Chi B, Glazer, Edward A, Froshauer, Susan A, Hayashi, Shigeru F, Kamicker, Barbara J, Reese, Catherine P, Olson, Julie A

“…Reductive amination of repromicin with polyfunctional amines has led to new macrolide antibacterial agents, some of which are highly potent against the…”
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Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles by Shavnya, Andrei, Sakya, Subas M., Minich, Martha L., Rast, Bryson, Lundy DeMello, Kristin, Jaynes, Burton H.

“…Fluoride-mediated nucleophilic substitution reactions of 1-(4-methylsulfonyl (or sulfonamido)-2-pyridyl)-5-chloro-4-cyano pyrazoles with various amines and…”
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In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1 H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity by Li, Jin, Bronk, Brian S., Dirlam, John P., Blize, Alan E., Bertinato, Peter, Jaynes, Burton H., Hickman, Anne, Miskell, Christine, Pillai, Usha A., Tibbitts, Jay S., Haven, Michelle L., Kolosko, Nicole L., Barry, Chris J., Manion, Tara B.

“…The synthesis of a novel gut selective MTP inhibitor, 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1 H-indole-2-carboxylic acid benzylmethyl…”
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Semisynthetic hygromycin A analogs: synthesis and anti-bacterial activity of derivatives lacking the furanose moiety by Jaynes, B H, Elliott, N C, Schicho, D L

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