Search Results - "Jayawickreme, C."

The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing by Covington, D K, Briscoe, C A, Brown, A J, Jayawickreme, C K

“…Recent deorphanization efforts have paired the G-protein-coupled receptors GPR40, GPR41 and GPR43 with fatty acids as endogenous ligands. While carboxylic…”
Get more information

Cloning and characterization of an endothelin-3 specific receptor (ETC receptor) from Xenopus laevis dermal melanophores by Karne, S., Jayawickreme, C.K., Lerner, M.R.

“…We report here the presence of a receptor specific for endothelin-3 (termed ETc receptor or ETcR) on Xenopus laevis dermal melanophores. Activation of ETcR…”
Get full text

Cloning and characterization of an endothelin-3 specific receptor (ET sub(C) receptor) from Xenopus laevis dermal melanophores by Karne, S, Jayawickreme, C K, Lerner, M R

“…We report here the presence of a receptor specific for endothelin-3 (termed ET sub(C) receptor or ET sub(C)R) on Xenopus laevis dermal melanophores. Activation…”
Get full text

Use of constitutive G protein-coupled receptor activity for drug discovery by Chen, G, Way, J, Armour, S, Watson, C, Queen, K, Jayawickreme, C K, Chen, W J, Kenakin, T

“…This article describes the behavior of transiently transfected human receptors into melanophores and the potential use of constitutive receptor activity to…”
Get more information

595 Differential ligand binding distinguishes therapeutic from pathologic Aryl Hydrocarbon Receptor (AhR) modulating agents: Implications for inflammatory skin disease by Smith, S., McHale, K., Creech, K., Rickard, D., Jayawickreme, C., Wu, D., Rastinejad, F., Rubenstein, D.

Get full text

Creation and Functional Screening of a Multi-Use Peptide Library by Jayawickreme, Channa K., Graminski, Gerard F., Quillan, J. Mark, Lerner, Michael R.

“…Studies of functional interactions between transmembrane proteins such as G-protein-coupled receptors and ligands would benefit from the ability to utilize…”
Get full text

Pigment dispersion in frog melanophores can be induced by a phorbol ester or stimulation of a recombinant receptor that activates phospholipase C by GRAMINSKI, G. F, JAYAWICKREME, C. K, POTENZA, M. N, LERNER, M. R

“…Pigment dispersion in frog melanophores is classically mediated by receptors that activate protein kinase A via an elevation of intracellular cyclic AMP. Here,…”
Get full text

Combinatorial Diffusion Assay Used to Identify Topically Active Melanocyte- Stimulating Hormone Receptor Antagonists by Quillan, J. Mark, Jayawickreme, Channa K., Lerner, Michael R.

“…α-Melanocyte-stimulating hormone (α-MSH) is implicated in pigmentation, central nervous system and immune system functions, growth, mitogenisis, and melanoma…”
Get full text

Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists by Jayawickreme, C K, Quillan, J M, Graminski, G F, Lerner, M R

“…Structure-function relationships of alpha-melanocyte-stimulating hormone (alpha-MSH, alpha-melanotropin) were investigated and novel alpha-MSH receptor…”
Get full text

Going to the well no more: lawn format assays for ultra-high-throughput screening by Marron, Brian E, Jayawickreme, Channa K

“…Screening in a ‘well-less’ or lawn format provides a means to screen large compound collections against many targets in a fast, versatile and cost effective…”
Get full text

LB985 GSK2967901A, a novel small molecule SIRT1 activator for the topical treatment of psoriasis by Ellis, J., Seefeld, M., Miller, W., Fox, R., Evans, K., Atkins, C., Dai, H., Jayawickreme, C., Bedard, M., Santos, L., Gupta, A., Grillot, D., Nicodeme, E., Weiss, M.

Get full text

Functional screening of multiuse peptide libraries using melanophore bioassay by Jayawickreme, C K, Jayawickreme, S P, Lerner, M R

Get more information

Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors by McClintock, Timothy S, Landers, Teresa M, Gimelbrant, Alexander A, Fuller, Lynn Z, Jackson, Brian A, Jayawickreme, Channa K, Lerner, Michael R

“…Replacing the G-protein-coupling domains of the β 2-adrenergic receptor with homologous domains of putative olfactory receptors produced chimeric receptors…”
Get full text

Generation of multiuse peptide libraries for functional screenings by Jayawickreme, C K, Jayawickreme, S P, Lerner, M R

Get more information

Functional expression of recombinant G-protein-coupled receptors monitored by video imaging of pigment movement in melanophores by McClintock, T S, Graminski, G F, Potenza, M N, Jayawickreme, C K, Roby-Shemkovitz, A, Lerner, M R

“…Xenopus laevis melanophores are capable of functionally expressing recombinant receptors which couple via G-proteins to adenylate cyclase or phospholipase C…”
Get more information

Use of a cell-based, lawn format assay to rapidly screen a 442,368 bead-based peptide library by Jayawickreme, Channa K, Sauls, Howard, Bolio, Natalie, Ruan, Jason, Moyer, Mary, Burkhart, Will, Marron, Brian, Rimele, Thomas, Shaffer, Joel

“…A cell-based, lawn format assay utilizing an in situ photocleavage method has been developed that allows the rapid examination of large bead-based compound…”
Get full text

Gene expression systems in the development of high-throughput screens by Jayawickreme, Channa K, Kost, Thomas A

“…Recent advances in the development of combinatorial automated chemical synthesis, robotic sample handling, and data collection and analysis have significantly…”
Get full text

Studies on zinc- and cadmium-bound proteins in bovine kidneys by biochemical and neutron activation techniques by Jayawickreme, C.K. (Dalhousie University, Halifax, NS, Canada), Chatt, A

“…Bovine kidneys were found to contain about 78 ppm Zn and 0.78 ppm Cd. Approximately 45% of Zn and 60% of Cd were present in the cytosol fraction. More than 95%…”
Get full text

Purification of a synaptic membrane Na+/Ca2+ antiporter and immunoextraction with antibodies to a 36-kDa protein by Michaelis, M L, Nunley, E W, Jayawickreme, C, Hurlbert, M, Schueler, S, Guilly, C

“…The conditions for optimal solubilization and reconstitution of bovine brain synaptic plasma membrane Na+/Ca2+ exchange activity were examined and a series of…”
Get more information

Some molecular properties of the synaptic plasma membrane Na(+)-Ca2+ exchanger by Michaelis, M L, Walsh, J L, Jayawickreme, C, Schueler, S, Hurlbert, M

Get more information