Search Results - "Jayasena, C. N"

Reduced Levels of Plasma Kisspeptin During the Antenatal Booking Visit Are Associated With Increased Risk of Miscarriage by Jayasena, C. N, Abbara, A, Izzi-Engbeaya, C, Comninos, A. N, Harvey, R. A, Gonzalez Maffe, J, Sarang, Z, Ganiyu-Dada, Z, Padilha, A. I, Dhanjal, M, Williamson, C, Regan, L, Ghatei, M. A, Bloom, S. R, Dhillo, W. S

“…Context: Kisspeptin is a recently identified hormone encoded by the KISS1 gene, playing a critical role in human reproduction. Plasma kisspeptin levels rise…”
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Twice-Weekly Administration of Kisspeptin-54 for 8 Weeks Stimulates Release of Reproductive Hormones in Women With Hypothalamic Amenorrhea by Jayasena, C N, Nijher, G M K, Abbara, A, Murphy, K G, Lim, A, Patel, D, Mehta, A, Todd, C, Donaldson, M, Trew, G H, Ghatei, M A, Bloom, S R, Dhillo, W S

“…Kisspeptin is a novel therapeutic target for infertility. A single kisspeptin‐54 (KP‐54) injection acutely stimulates the release of reproductive hormones in…”
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A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women by Jayasena, C. N., Comninos, A. N., Veldhuis, J. D., Misra, S., Abbara, A., Izzi-Engbeaya, C., Donaldson, M., Ghatei, M. A., Bloom, S. R., Dhillo, W. S.

“…Summary Background Kisspeptin is a novel hypothalamic peptide which stimulates endogenous gonadotrophin releasing hormone (GnRH) secretion. A single…”
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The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly by Jayasena, C. N., Comninos, A. N., Clarke, H., Donaldson, M., Meeran, K., Dhillo, W. S.

“…Summary Background  Acromegaly is characterized by the hypersecretion of growth hormone (GH) and insulin‐like growth factor‐1 (IGF‐1). This leads to an…”
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Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem by Beale, KEL, Gardiner, JV, Bewick, GA, Hostomska, K, Patel, NA, Hussain, SS, Jayasena, CN, Ebling, FJP, Jethwa, PH, Prosser, HM, Lattanzi, R, Negri, L, Ghatei, MA, Bloom, SR, Dhillo, WS

“…Background and Purpose Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors…”
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Which patients with gynaecomastia require more detailed investigation? by Ali, S.N., Jayasena, C.N., Sam, A.H.

“…Summary Gynaecomastia may be due to medication, chronic liver or kidney disease, hypogonadism (primary or secondary to pituitary disease) or hyperthyroidism…”
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Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers by Jayasena, C. N, Comninos, A. N, Nijher, G. M. K, Abbara, A, De Silva, A, Veldhuis, J. D, Ratnasabapathy, R, Izzi-Engbeaya, C, Lim, A, Patel, D. A, Ghatei, M. A, Bloom, S. R, Dhillo, W. S

“…Background: Kisspeptin is a critical hypothalamic regulator of reproductive function. Chronic kisspeptin administration causes profound tachyphylaxis in male…”
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Gut Hormones: A Weight Off Your Mind by Gardiner, J. V., Jayasena, C. N., Bloom, S. R.

“…The increasing prevalence of obesity and the associated morbidity and mortality has resulted in a major research effort to identify mechanisms that regulate…”
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Comparison of the Dexamethasone-Suppressed Corticotropin-Releasing Hormone Test and Low-Dose Dexamethasone Suppression Test in the Diagnosis of Cushing’s Syndrome by Martin, N. M., Dhillo, W. S., Banerjee, A., Abdulali, A., Jayasena, C. N., Donaldson, M., Todd, J. F., Meeran, K.

“…Context: The low-dose dexamethasone suppression test (LDDST) is widely used in confirming a diagnosis of Cushing’s syndrome. CRH administration at the end of…”
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Testosterone therapy for sexual dysfunction in men with Type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials by Algeffari, M., Jayasena, C. N., MacKeith, P., Thapar, A., Dhillo, W. S., Oliver, N.

“…Aim To evaluate the effectiveness of testosterone therapy on a range of sexual function domains in men with Type 2 diabetes. Method Electronic databases were…”
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Measurement of basal growth hormone (GH) is a useful test of disease activity in treated acromegalic patients by Jayasena, C. N., Wujanto, C., Donaldson, M., Todd, J. F., Meeran, K.

“…Summary Background  Nadir GH during oral glucose tolerance test (OGTT) is the gold‐standard test of GH secretion in treated acromegaly. However, it was…”
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Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men by Jayasena, C.N., Abbara, A., Narayanaswamy, S., Comninos, A.N., Ratnasabapathy, R., Bassett, P., Mogford, J.T., Malik, Z., Calley, J., Ghatei, M.A., Bloom, S.R., Dhillo, W.S.

“…STUDY QUESTION How potently does the novel hypothalamic stimulator of reproduction, kisspeptin, increase gonadotrophin secretion when compared with GnRH in…”
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Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage by Jayasena, C.N., Abbara, A., Comninos, A.N., Narayanaswamy, S., Gonzalez Maffe, J., Izzi-Engbeaya, C., Oldham, J., Lee, T.T.M., Sarang, Z., Malik, Z., Dhanjal, M.K., Williamson, C., Regan, L., Bloom, S.R., Dhillo, W.S.

“…STUDY QUESTION Are novel circulating placental markers prokineticin-1 (PK-1), soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng) and…”
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Plasma gastrin measurement cannot be used to diagnose a gastrinoma in patients on either proton pump inhibitors or histamine type-2 receptor antagonists by Dhillo, W S, Jayasena, C N, Lewis, C J, Martin, N M, Tang, K C N, Meeran, K, Todd, J F

“…Patients with a gastrinoma are treated with proton pump inhibitors (PPI) and histamine type-2 receptor antagonists (H2). In order to diagnose a gastrinoma…”
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Kisspeptins and the control of gonadotropin secretion in humans by Jayasena, C.N., Dhillo, W.S., Bloom, S.R.

“…The kisspeptin hormones are a family of peptides encoded by the KiSS-1 gene, which bind to the G-protein coupled receptor-54 (GPR54). Interactions between…”
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How to manage low testosterone level in men: a guide for primary care by Al-Sharefi, Ahmed, Wilkes, Scott, Jayasena, Channa N, Quinton, Richard

“…Quinton et al discuss how to manage low testosterone level in men in the primary care setting. Male hypogonadism is a clinical syndrome characterized by…”
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Stimulation of Leydig and Sertoli Cellular Secretory Function by Anti-Oestrogens: Tamoxifen by Dimakopoulou, Anastasia, Foran, Daniel, Jayasena, Channa N, Minhas, Suks

“…Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the…”
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7945 Modelling the Factors Associated With Sexual and Mood Symptoms Within the First Year of Anabolic-Androgenic Steroid Cessation in Men by Grant, B, Kean, J, de Silva, N L, Quinton, O, Bassett, P, McVeigh, J, Lingford-Hughes, A, Minhas, S, Bhasin, S, Dhillo, W S, Jayasena, C N

“…Disclosure: B. Grant: None. J. Kean: None. N.L. de Silva: None. O. Quinton: None. P. Bassett: None. J. McVeigh: None. A. Lingford-Hughes: None. S. Minhas:…”
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7945 Modelling the Factors Associated With Sexual and Mood Symptoms Within the First Year of Anabolic-Androgenic Steroid Cessation in Men by Grant, B, Kean, J, de Silva, N L, Quinton, O, Bassett, P, McVeigh, J, Lingford-Hughes, A, Minhas, S, Bhasin, S, Dhillo, W S, Jayasena, C N

“…Disclosure: B. Grant: None. J. Kean: None. N.L. de Silva: None. O. Quinton: None. P. Bassett: None. J. McVeigh: None. A. Lingford-Hughes: None. S. Minhas:…”
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Kisspeptin and fertility by Hameed, Saira, Jayasena, Channa N, Dhillo, Waljit S

“…The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the…”
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