Search Results - "Jayaram, Hiremagalur N"

Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation by Liangpunsakul, Suthat, Wou, Sung-Eun, Zeng, Yan, Ross, Ruth A, Jayaram, Hiremagalur N, Crabb, David W

“…AMP-activated protein kinase (AMPK) responds to oxidative stress. Previous work has shown that ethanol treatment of cultured hepatoma cells and of mice…”
Get more information

Variability of Apoptosis and Response in N1-S1 Rodent Hepatomas to Benzamide Riboside and Correlation to Early Changes in Water Apparent Diffusion Coefficient and Sodium MR Imaging by Faramarzalian, Ali, BS, McLennan, Gordon, MD, Bennett, Stacy L., BS, Babsky, Andriy, MD, Bansal, Navin, MD, Lieber, Michael, MS, Bonnac, Laurent, PhD, Pankiewicz, Krystoff, PhD, Jayaram, Hiremagalur N., PhD

“…Abstract Purpose This pilot trial assesses variability of apoptosis and response 1 day after hepatic intraarterial (IA) benzamide riboside (BR) in rodent…”
Get full text

Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats: An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers by Ju, Shenghong, MD, McLennan, Gordon, MD, Bennett, Stacy L., BS, Liang, Yun, PhD, Bonnac, Laurent, PhD, Pankiewicz, Krzysztof W., PhD, Jayaram, Hiremagalur N., PhD

“…The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging…”
Get full text

Can targeting organic anion transporter polypeptide (OATP) genes play a key role in drug therapy by Jayaram, Hiremagalur N., Kusumanchi, Praveen

“…Commentary to: Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinomal Katrin Wlcek, Martin Svoboda, Franz Sellner,…”
Get full text

Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas by Yalowitz, Joel A, Xiao, Suhong, Biju, Mangatt P, Antony, Aśok C, Cummings, Oscar W, Deeg, Mark A, Jayaram, Hiremagalur N

“…NMNAT (nicotinamide 5'-mononucleotide adenylyltransferase; EC 2.7.7.1) catalyses the transfer of the adenylyl group from ATP to NMN to form NAD. We have cloned…”
Get full text

Cloning, expression and characterization of mouse (Mus musculus) nicotinamide 5'-mononucleotide adenylyltransferase-2 by Raches, David W, Xiao, Suhong, Kusumanchi, Praveen, Yalowitz, Joel, Sanghani, Paresh, Long, Eric C, Antony, Aśok C, Jayaram, Hiremagalur N

“…Nicotinamide adenine dinucleotide (NAD+) is synthesized by the action of nicotinamide mononucleotide adenylyltransferase (NMNAT) from NMN and ATP. The mouse…”
Get more information

Dual Inhibitors of Inosine Monophosphate Dehydrogenase and Histone Deacetylases for Cancer Treatment by Chen, Liqiang, Wilson, Daniel, Jayaram, Hiremagalur N, Pankiewicz, Krzysztof W

“…Mycophenolic acid (MPA), an inhibitor of IMP-dehydrogenase (IMPDH), is used worldwide in transplantation. Recently, numerous studies showed its importance in…”
Get full text

Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells by Tang, Ying-Sheng, Khan, Rehana A, Xiao, Suhong, Hansen, Deborah K, Stabler, Sally P, Kusumanchi, Praveen, Jayaram, Hiremagalur N, Antony, Aśok C

“…Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency. In…”
Get more information

Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside by Damaraju, Vijaya L, Visser, Frank, Zhang, Jing, Mowles, Delores, Ng, Amy M L, Young, James D, Jayaram, Hiremagalur N, Cass, Carol E

“…Benzamide riboside (BR) and tiazofurin (TR) are converted to analogs of NAD that inhibit IMP dehydrogenase (IMPDH), resulting in cellular depletion of GTP and…”
Get more information

Incrimination of Heterogeneous Nuclear Ribonucleoprotein E1 (hnRNP-E1) as a Candidate Sensor of Physiological Folate Deficiency by Tang, Ying-Sheng, Khan, Rehana A., Zhang, Yonghua, Xiao, Suhong, Wang, Mu, Hansen, Deborah K., Jayaram, Hiremagalur N., Antony, Aśok C.

“…The mechanism underlying the sensing of varying degrees of physiological folate deficiency, prior to adaptive optimization of cellular folate uptake through…”
Get full text

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure by Chen, Liqiang, Petrelli, Riccardo, Gao, Guangyao, Wilson, Daniel J., McLean, Garrett T., Jayaram, Hiremagalur N., Sham, Yuk Y., Pankiewicz, Krzysztof W.

“…Small molecules that act on multiple biological targets have been proposed to combat the drug resistance commonly observed for cancer chemotherapy. By…”
Get full text

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3′-C-methyladenosine by Petrelli, Riccardo, Meli, Maria, Vita, Patrizia, Torquati, Ilaria, Ferro, Arianna, Vodnala, Munender, D’Alessandro, Natale, Tolomeo, Manlio, Del Bello, Fabio, Kusumanchi, Praveen, Franchetti, Palmarisa, Grifantini, Mario, Jayaram, Hiremagalur N., Hofer, Anders, Cappellacci, Loredana

“…[Display omitted] We synthesized a series of serum-stable covalently linked drugs derived from 3′-C-methyladenosine (3′-Me-Ado) and valproic acid (VPA), which…”
Get full text

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain by Felczak, Krzysztof, Chen, Liqiang, Wilson, Daniel, Williams, Jessica, Vince, Robert, Petrelli, Riccardo, Jayaram, Hiremagalur N., Kusumanchi, Praveen, Kumar, Mohineesh, Pankiewicz, Krzysztof W.

“…Cofactor-type inhibitors of inosine monophosphate dehydrogenase (IMPDH) that target the nicotinamide adenine dinucleotide (NAD) binding domain of the enzyme…”
Get full text

Influence of Physiologic Folate Deficiency on Human Papillomavirus Type 16 (HPV16)-harboring Human Keratinocytes in Vitro and in Vivo by Xiao, Suhong, Tang, Ying-Sheng, Khan, Rehana A., Zhang, Yonghua, Kusumanchi, Praveen, Stabler, Sally P., Jayaram, Hiremagalur N., Antony, Aśok C.

“…Although HPV16 transforms infected epithelial tissues to cancer in the presence of several co-factors, there is insufficient molecular evidence that poor…”
Get full text

Ribose-Modified Purine Nucleosides as Ribonucleotide Reductase Inhibitors. Synthesis, Antitumor Activity, and Molecular Modeling of N 6-Substituted 3′-C-Methyladenosine Derivatives by Cappellacci, Loredana, Franchetti, Palmarisa, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Jayaram, Hiremagalur N, Saiko, Philipp, Graser, Geraldine, Szekeres, Thomas, Grifantini, Mario

“…A series of cycloalkyl, bicycloalkyl, aryl, and heteroaryl N 6-substituted derivatives of the antitumor agent 3′-C-methyladenosine (3′-Me-Ado), an inhibitor of…”
Get full text

Predicting Response to Benzamide Riboside Chemotherapy in Hepatocellular Carcinoma Using Apparent Diffusion Coefficient of Water by BABSKY, Andriy M, SHENGHONG JU, GEORGE, Beena, BENNETT, Stacy, HUANG, Mingsheng, JAYARAM, Hiremagalur N, MCLENNAN, Gordon, BANSAL, Navin

“…To monitor the effects of the apoptotic agent benzamide riboside (BR) on tumor volume and water apparent diffusion coefficient (ADC) in rat hepatocellular…”
Get full text

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase by Liangpunsakul, Suthat, Wou, Sung-Eun, Wineinger, Kevin D., Zeng, Yan, Cyganek, Izabela, Jayaram, Hiremagalur N., Crabb, David W.

“…AMP-dependent protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR) α facilitate fatty acid oxidation. We have shown that treatment of…”
Get full text

Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents by CAPPELLACCI, Loredana, PETRELLI, Riccardo, FRANCHETTI, Palmarisa, VITA, Patrizia, KUSUMANCHI, Praveen, KUMAR, Mohineesh, JAYARAM, Hiremagalur N, BINGSEN ZHOU, YUN YEN, GRIFANTINI, Mario

“…A series of N6-aminopurine-9-β-D-ribonucleosides and ribose-modified 3'-C-methyl analogues substituted at N6-position with a small group like hydroxy, methoxy…”
Get full text

Mycophenolic acid analogs with a modified metabolic profile by Chen, Liqiang, Wilson, Daniel J., Labello, Nicholas P., Jayaram, Hiremagalur N., Pankiewicz, Krzysztof W.

“…Aiming to circumvent the metabolic liability imposed by mycophenolic acid (MPA), a series of MPA analogs have been designed by combining the structural…”
Get full text

Probing Binding Requirements of Type I and Type II Isoforms of Inosine Monophosphate Dehydrogenase with Adenine-Modified Nicotinamide Adenine Dinucleotide Analogues by Chen, Liqiang, Gao, Guangyao, Felczak, Krzysztof, Bonnac, Laurent, Patterson, Steven E, Wilson, Daniel, Bennett, Eric M, Jayaram, Hiremagalur N, Hedstrom, Lizbeth

“…Novel tiazofurin adenine dinucleotide (TAD) analogues 25 − 33 containing a substituent at C2 of the adenine ring have been synthesized as inhibitors of the two…”
Get full text