Search Results - "Jayanth, V."

Concentrated Growth Factors as an Ingenious Biomaterial in Regeneration of Bony Defects after Periapical Surgery: A Report of Two Cases by Nandakumar, Mahalakshmi, V, Jayanth Kumar, Selvarasu, Kathiravan, Malli Sureshbabu, Nivedhitha, Selvam, Deepak

“…The overall success of a periapical surgery is assessed in terms of regeneration of functional periradicular tissues. The regenerative potential of platelets…”
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Diabetes and Tooth Loss: An analysis of data from the National Health and Nutrition Examination Survey, 2003–2004 by Patel, Manthan H., BDS, MPH, Kumar, Jayanth V., DDS, MPH, Moss, Mark E., DDS, MS, PhD

“…ABSTRACT Background The authors conducted an analysis of data from the National Health and Nutrition Examination Survey (NHANES) to understand the association…”
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Human PLD structures enable drug design and characterization of isoenzyme selectivity by Metrick, Claire M., Peterson, Emily A., Santoro, Joseph C., Enyedy, Istvan J., Murugan, Paramasivam, Chen, TeYu, Michelsen, Klaus, Cullivan, Michael, Spilker, Kerri A., Kumar, P. Rajesh, May-Dracka, Tricia L., Chodaparambil, Jayanth V.

“…Phospholipase D enzymes (PLDs) are ubiquitous phosphodiesterases that produce phosphatidic acid (PA), a key second messenger and biosynthetic building block…”
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Association between low fluoride exposure and children's intelligence: a meta-analysis relevant to community water fluoridation by Kumar, Jayanth V., Moss, Mark E., Liu, Honghu, Fisher-Owens, Susan

“…Previous meta-analyses have mainly focused on studies conducted in endemic fluorosis areas with relatively high fluoride concentrations. These are impoverished…”
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The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure by Luger, Karolin, Lu, Xu, Simon, Matthew D, Chodaparambil, Jayanth V, Hansen, Jeffrey C, Shokat, Kevan M

“…Histone methylation regulates chromatin function dependent on the site and degree of the modification. In addition to creating binding sites for proteins,…”
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Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA by Barbera, Andrew J, Chodaparambil, Jayanth V, Kelley-Clarke, Brenna, Joukov, Vladimir, Walter, Johannes C, Luger, Karolin, Kaye, Kenneth M

“…Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that…”
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The Discovery of 7‑Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)‑N‑(6-methylpyrazolo[1,5‑a]pyrimidin-3-yl)imidazo[1,2‑a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke by Evans, Ryan, Bolduc, Philippe N., Pfaffenbach, Magnus, Gao, Fang, May-Dracka, Tricia, Fang, Terry, Hopkins, Brian T., Chodaparambil, Jayanth V, Henry, Kate L., Li, Pei, Metrick, Claire, Nelson, Ashley, Trapa, Patrick, Thomas, Ankur, Burkly, Linda, Peterson, Emily A.

“…Interleukin receptor-associated kinase 4 (IRAK4) is a key node of signaling within the innate immune system that regulates the production of inflammatory…”
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Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms by Bao, Channa, Bajrami, Bekim, Marcotte, Douglas J., Chodaparambil, Jayanth V., Kerns, Hannah M., Henderson, Jaclyn, Wei, Ru, Gao, Benbo, Dillon, Gregory M.

“…Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer’s Disease (AD) and…”
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Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation by Pfaffenbach, Magnus, Bolduc, Philippe N., Xin, Zhili, Gao, Fang, Evans, Ryan, Fang, Terry, Chodaparambil, Jayanth V., Henry, Kate L., Li, Pei, Mathieu, Steven, Metrick, Claire, Vera Rebollar, Jorge A., Gu, Rong-Fang, Mccarl, Christie-Ann, Silbereis, John, Peterson, Emily A.

“…Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and…”
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Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo by Halkina, Tamara, Henderson, Jaclyn L, Lin, Edward Y, Himmelbauer, Martin K, Jones, J. Howard, Nevalainen, Marta, Feng, Jun, King, Kristopher, Rooney, Michael, Johnson, Joshua L, Marcotte, Douglas J, Chodaparambil, Jayanth V, Kumar, P. Rajesh, Patterson, Thomas A, Murugan, Paramasivam, Schuman, Eli, Wong, LaiYee, Hesson, Thomas, Lamore, Sarah, Bao, Channa, Calhoun, Michael, Certo, Hannah, Amaral, Brenda, Dillon, Gregory M, Gilfillan, Rab, de Turiso, Felix Gonzalez-Lopez

“…Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1…”
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Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution by Miller, Phillip W., Pokutta, Sabine, Mitchell, Jennyfer M., Chodaparambil, Jayanth V., Clarke, D. Nathaniel, Nelson, W. James, Weis, William I., Nichols, Scott A.

“…The evolution of cell-adhesion mechanisms in animals facilitated the assembly of organized multicellular tissues. Studies in traditional animal models have…”
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Molecular functions of the TLE tetramerization domain in Wnt target gene repression by Chodaparambil, Jayanth V, Pate, Kira T, Hepler, Margretta R D, Tsai, Becky P, Muthurajan, Uma M, Luger, Karolin, Waterman, Marian L, Weis, William I

“…Wnt signaling activates target genes by promoting association of the co‐activator β‐catenin with TCF/LEF transcription factors. In the absence of β‐catenin,…”
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Does water fluoridation affect the prevalence of enamel fluorosis differently among racial and ethnic groups? by Arora, Shivani, Kumar, Jayanth V., Moss, Mark Eric

“…Objectives There are reports showing higher prevalence of enamel fluorosis among African‐American children. This study was conducted to assess whether the…”
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Nucleosome Assembly Protein 1 Exchanges Histone H2A-H2B Dimers and Assists Nucleosome Sliding by Park, Young-Jun, Chodaparambil, Jayanth V., Bao, Yunhe, McBryant, Steven J., Luger, Karolin

“…Eukaryotic chromatin is highly dynamic and turns over rapidly even in the absence of DNA replication. Here we show that the acidic histone chaperone nucleosome…”
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Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors by Amaral, Brenda, Capacci, Andrew, Anderson, Trip, Tezer, Ceren, Bajrami, Bekim, Lulla, Mukesh, Lucas, Brian, Chodaparambil, Jayanth V., Marcotte, Douglas, Kumar, P. Rajesh, Murugan, Paramasivam, Spilker, Kerri, Cullivan, Mike, Wang, Ti, Peterson, Anton C., Enyedy, Istvan, Ma, Bin, Chen, TeYu, Yousaf, Zain, Calhoun, Michael, Golonzhka, Olga, Dillon, Gregory M., Koirala, Samir

“…Glycogen synthase kinase 3 (GSK3) remains a therapeutic target of interest for diverse clinical indications. However, one hurdle in the development of small…”
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A charged and contoured surface on the nucleosome regulates chromatin compaction by Luger, Karolin, Chodaparambil, Jayanth V, Barbera, Andrew J, Lu, Xu, Kaye, Kenneth M, Hansen, Jeffrey C

“…Local nucleosome-nucleosome interactions in cis drive chromatin folding, whereas interactions in trans lead to fiber-fiber oligomerization. Here we show that…”
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Early childhood caries–related visits to emergency departments and ambulatory surgery facilities and associated charges in New York state by Nagarkar, Sanket R., BDS, MPH, Kumar, Jayanth V., DDS, MPH, Moss, Mark E., DDS, MS, PhD

“…ABSTRACT Background The authors assessed the extent of early childhood caries– (ECC-) related visits to emergency departments (EDs) and ambulatory surgery…”
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Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546 by Ma, Bin, Zhang, Lei, Sun, Lihong, Xin, Zhili, Kumaravel, Gnanasambandam, Marcotte, Douglas, Chodaparambil, Jayanth V, Wang, Qin, Wehr, Angela, Jing, Jing, Hong, Victor Sukbong, Wang, Ti, Huang, Carol, Shao, Zhaohui, Mi, Sha

“…Autotaxin (ATX) is a lysophospholipase D that is the main enzyme responsible for generating LPA in body fluids. Although ATX was isolated from a conditioned…”
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Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements by Prathoshini, Manthra

“…Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause…”
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Antibody persistence following administration of a hexavalent DTwP-IPV-HB-PRP∼T vaccine versus separate DTwP-HB-PRP∼T and IPV vaccines at 12–24 months of age and safety and immunogenicity of a booster dose of DTwP-IPV-HB-PRP∼T in healthy infants in India by Mangarule, S, Palkar, S, Mitra, M, Ravi, MD, Singh, R, Moureau, A, Jayanth, MV, Patel, DM, Ravinuthala, S, Patnaik, BN, Jordanov, E, Noriega, F

“…The combination of whole-cell pertussis (wP) antigens with established diphtheria (D), tetanus (T), hepatitis B (HB), Haemophilus influenzae type b (Hib), and…”
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