Search Results - "Jayanta Debnath"

Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease by Murrow, Lyndsay, Debnath, Jayanta

“…Autophagy, a vital catabolic process that degrades cytoplasmic components within the lysosome, is an essential cytoprotective response to pathologic stresses…”
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Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins by Cadwell, Ken, Debnath, Jayanta

“…The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs…”
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Autophagy and the cell biology of age-related disease by Leidal, Andrew M., Levine, Beth, Debnath, Jayanta

“…Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence…”
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The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion by Vlahakis, Ariadne, Debnath, Jayanta

“…Autophagy is a cellular degradation process integral for promoting cellular adaptation during metabolic stress while also functioning as a cellular homeostatic…”
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Cellular and metabolic functions for autophagy in cancer cells by Kenific, Candia M, Debnath, Jayanta

“…Highlights • Autophagy sustains metabolic pathways required for aggressive tumor growth. • The unfolded protein response induces cytoprotective autophagy in…”
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Lysosomal lipid peroxidation mediates immunogenic cell death by Phadatare, Pravin, Debnath, Jayanta

“…Cancer cells rely on lysosome-dependent degradation to recycle nutrients that serve their energetic and biosynthetic needs. Despite great interest in…”
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Autophagy and tumorigenesis by Chen, Nan, Debnath, Jayanta

“…Autophagy, or cellular self-digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival…”
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The pleiotropic functions of autophagy in metastasis by Marsh, Timothy, Tolani, Bhairavi, Debnath, Jayanta

“…Autophagy is deregulated in many cancers and represents an attractive target for therapeutic intervention. However, the precise contributions of autophagy to…”
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Detachment-induced autophagy during anoikis and lumen formation in epithelial acini by Debnath, Jayanta

“…The individual units (called acini) comprising glandular epithelium possess a hollow lumen that is filled in early epithelial cancers. While investigating the…”
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The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles by Leidal, Andrew M., Huang, Hector H., Marsh, Timothy, Solvik, Tina, Zhang, Dachuan, Ye, Jordan, Kai, FuiBoon, Goldsmith, Juliet, Liu, Jennifer Y., Huang, Yu-Hsin, Monkkonen, Teresa, Vlahakis, Ariadne, Huang, Eric J., Goodarzi, Hani, Yu, Li, Wiita, Arun P., Debnath, Jayanta

“…Traditionally viewed as an autodigestive pathway, autophagy also facilitates cellular secretion; however, the mechanisms underlying these processes remain…”
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Unconventional secretion: cargo channeling by TMED10 by Nguyen, Tan A., Debnath, Jayanta

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ATG12-ATG3 connects basal autophagy and late endosome function by Murrow, Lyndsay, Debnath, Jayanta

“…In addition to supporting cell survival in response to starvation or stress, autophagy promotes basal protein and organelle turnover. Compared to our…”
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Induction of autophagy during extracellular matrix detachment promotes cell survival by Fung, Christopher, Lock, Rebecca, Gao, Sizhen, Salas, Eduardo, Debnath, Jayanta

“…Autophagy has been proposed to promote cell death during lumen formation in three-dimensional mammary epithelial acini because numerous autophagic vacuoles are…”
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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease by Spilman, Patricia, Podlutskaya, Natalia, Hart, Matthew J, Debnath, Jayanta, Gorostiza, Olivia, Bredesen, Dale, Richardson, Arlan, Strong, Randy, Galvan, Veronica

“…Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1], [2], [3], [4]. It was recently demonstrated that…”
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Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression by Marsh, Timothy, Kenific, Candia M., Suresh, Deepthisri, Gonzalez, Hugo, Shamir, Eliah R., Mei, Wenbin, Tankka, Alexandra, Leidal, Andrew M., Kalavacherla, Sandhya, Woo, Kimberly, Werb, Zena, Debnath, Jayanta

“…Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality,…”
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Autophagy in malignant transformation and cancer progression by Galluzzi, Lorenzo, Pietrocola, Federico, Bravo-San Pedro, José Manuel, Amaravadi, Ravi K, Baehrecke, Eric H, Cecconi, Francesco, Codogno, Patrice, Debnath, Jayanta, Gewirtz, David A, Karantza, Vassiliki, Kimmelman, Alec, Kumar, Sharad, Levine, Beth, Maiuri, Maria Chiara, Martin, Seamus J, Penninger, Josef, Piacentini, Mauro, Rubinsztein, David C, Simon, Hans-Uwe, Simonsen, Anne, Thorburn, Andrew M, Velasco, Guillermo, Ryan, Kevin M, Kroemer, Guido

“…Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against…”
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Secretory autophagy maintains proteostasis upon lysosome inhibition by Solvik, Tina A, Nguyen, Tan A, Tony Lin, Yu-Hsiu, Marsh, Timothy, Huang, Eric J, Wiita, Arun P, Debnath, Jayanta, Leidal, Andrew M

“…The endolysosome system plays central roles in both autophagic degradation and secretory pathways, including the release of extracellular vesicles and…”
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Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion by Lock, Rebecca, Kenific, Candia M, Leidal, Andrew M, Salas, Eduardo, Debnath, Jayanta

“…The tumor-promoting functions of autophagy are primarily attributed to its ability to promote cancer cell survival. However, emerging evidence suggests that…”
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Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion by Leidal, Andrew M., Debnath, Jayanta

“…Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via…”
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Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation by Lock, Rebecca, Roy, Srirupa, Kenific, Candia M, Su, Judy S, Salas, Eduardo, Ronen, Sabrina M, Debnath, Jayanta

“…The protumorigenic functions for autophagy are largely attributed to its ability to promote cancer cell survival in response to diverse stresses. Here we…”
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