Search Results - "Jayachandran N. Kizhakkedathu"

Biomaterial and cellular implants: foreign surfaces where immunity and coagulation meet by Kizhakkedathu, Jayachandran N., Conway, Edward M.

“…Exposure of blood to a foreign surface in the form of a diagnostic or therapeutic biomaterial device or implanted cells or tissue elicits an immediate,…”
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Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo by Kumar, Prashant, Kizhakkedathu, Jayachandran N, Straus, Suzana K

“…Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance…”
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Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance by Drayton, Matthew, Kizhakkedathu, Jayachandran N, Straus, Suzana K

“…Antimicrobial peptides (AMPs), otherwise known as host defence peptides (HDPs), are naturally occurring biomolecules expressed by a large array of species…”
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Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections by Kazemzadeh-Narbat, Mehdi, Lai, Benjamin F.L, Ding, Chuanfan, Kizhakkedathu, Jayachandran N, Hancock, Robert E.W, Wang, Rizhi

“…Abstract Prevention of bacterial colonization and formation of a bacterial biofilm on implant surfaces has been a challenge in orthopaedic surgery. The…”
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Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface by Abbina, Srinivas, Takeuchi, Lily E., Anilkumar, Parambath, Yu, Kai, Rogalski, Jason C., Shenoi, Rajesh A., Constantinescu, Iren, Kizhakkedathu, Jayachandran N.

“…Nanomaterials in the blood must mitigate the immune response to have a prolonged vascular residency in vivo. The composition of the protein corona that forms…”
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Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes by Yu, Kai, Andruschak, Paula, Yeh, Han Hung, Grecov, Dana, Kizhakkedathu, Jayachandran N.

“…The information regarding the nature of protein corona (and its changes) and cell binding on biomaterial surface under dynamic conditions is critical to…”
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Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity by Moradi, Sona, Hadjesfandiari, Narges, Toosi, Salma Fallah, Kizhakkedathu, Jayachandran N, Hatzikiriakos, Savvas G

“…In order to design antithrombotic implants, the effect of extreme wettability (superhydrophilicity to superhydrophobicity) on the biocompatibility of the…”
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Development of an iron overload HepG2 cell model using ferrous ammonium citrate by Abbasi, Usama, Abbina, Srinivas, Gill, Arshdeep, Kizhakkedathu, Jayachandran N.

“…Cell-based iron overload models provide tremendous utility for the investigations into the pathogenesis of different diseases as well as assessing efficacy of…”
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Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates by Kleifeld, Oded, Doucet, Alain, Prudova, Anna, auf dem Keller, Ulrich, Gioia, Magda, Kizhakkedathu, Jayachandran N, Overall, Christopher M

“…Analysis of the sequence and nature of protein N termini has many applications. Defining the termini of proteins for proteome annotation in the Human Proteome…”
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A facile colorimetric method for the quantification of labile iron pool and total iron in cells and tissue specimens by Abbasi, Usama, Abbina, Srinivas, Gill, Arshdeep, Bhagat, Vriti, Kizhakkedathu, Jayachandran N.

“…Quantification of iron is an important step to assess the iron burden in patients suffering from iron overload diseases, as well as tremendous value in…”
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Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products by Kizhakkedathu, Jayachandran N, Overall, Christopher M, Kleifeld, Oded, Doucet, Alain, auf dem Keller, Ulrich, Prudova, Anna, Schilling, Oliver, Kainthan, Rajesh K, Starr, Amanda E, Foster, Leonard J

“…Effective proteome-wide strategies that distinguish the N-termini of proteins from the N-termini of their protease cleavage products would accelerate…”
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Antibacterial Surfaces Based on Polymer Brushes: Investigation on the Influence of Brush Properties on Antimicrobial Peptide Immobilization and Antimicrobial Activity by Gao, Guangzheng, Yu, Kai, Kindrachuk, Jason, Brooks, Donald E, Hancock, Robert E. W, Kizhakkedathu, Jayachandran N

“…Primary amine containing copolymer, poly­( N,N -dimethylacrylamide-co-N-(3-aminopropyl)­methacrylamide hydrochloride) (poly­(DMA-co-APMA)), brushes were…”
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Inhibitors of Polyphosphate and Neutrophil Extracellular Traps by Vappala, Sreeparna, Smith, Stephanie A, Kizhakkedathu, Jayachandran N, Morrissey, James H

“…The contact pathway of blood clotting has received intense interest in recent years as studies have linked it to thrombosis, inflammation, and innate immunity…”
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Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation by Xu, Tao, Ji, Haifeng, Xu, Lin, Cheng, Shengjun, Liu, Xianda, Li, Yupei, Zhong, Rui, Zhao, Weifeng, Kizhakkedathu, Jayachandran N., Zhao, Changsheng

“…Clinical use of intraoperative auto-transfusion requires the removal of platelets and plasma proteins due to pump-based suction and water-soluble anticoagulant…”
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Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization by Godoy-Gallardo, Maria, Mas-Moruno, Carlos, Yu, Kai, Manero, José M, Gil, Francisco J, Kizhakkedathu, Jayachandran N, Rodriguez, Daniel

“…Dental implant failure can be associated with infections that develop into peri-implantitis. In order to reduce biofilm formation, several strategies focusing…”
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Enzymatic conversion of human blood group A kidneys to universal blood group O by MacMillan, Serena, Hosgood, Sarah A., Walker-Panse, Léonie, Rahfeld, Peter, Macdonald, Spence S., Kizhakkedathu, Jayachandran N., Withers, Stephen G., Nicholson, Michael L.

“…ABO blood group compatibility restrictions present the first barrier to donor-recipient matching in kidney transplantation. Here, we present the use of two…”
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The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury by Späth, Martin R, Bartram, Malte P, Palacio-Escat, Nicolàs, Hoyer, K Johanna R, Debes, Cedric, Demir, Fatih, Schroeter, Christina B, Mandel, Amrei M, Grundmann, Franziska, Ciarimboli, Giuliano, Beyer, Andreas, Kizhakkedathu, Jayachandran N, Brodesser, Susanne, Göbel, Heike, Becker, Jan U, Benzing, Thomas, Schermer, Bernhard, Höhne, Martin, Burst, Volker, Saez-Rodriguez, Julio, Huesgen, Pitter F, Müller, Roman-Ulrich, Rinschen, Markus M

“…Acute kidney injury (AKI) leads to significant morbidity and mortality; unfortunately, strategies to prevent or treat AKI are lacking. In recent years, several…”
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Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis by Travers, Richard J., Shenoi, Rajesh A., Kalathottukaren, Manu Thomas, Kizhakkedathu, Jayachandran N., Morrissey, James H.

“…Polyphosphate (polyP) is secreted by activated platelets and has been shown to contribute to thrombosis, suggesting that it could be a novel antithrombotic…”
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Surface Engineering for Cell-Based Therapies: Techniques for Manipulating Mammalian Cell Surfaces by Abbina, Srinivas, Siren, Erika M. J, Moon, Haisle, Kizhakkedathu, Jayachandran N

“…The introduction of cell-based therapies has provided new and unique strategies to treat many diseases and disorders including the recent approval of CAR-T…”
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A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment by Yu, Xifei, Yang, Xiaoqiang, Horte, Sonja, Kizhakkedathu, Jayachandran N, Brooks, Donald E

“…Abstract Solid tumors generally exhibit an acidic microenvironment which has been recognized as a potential route to distinguishing tumor from normal tissue…”
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