Search Results - "Jay, Gregory"

The biology of Lubricin: Near frictionless joint motion by Jay, Gregory D., Waller, Kimberly A.

“…Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints,…”
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The Engaged Humanities: Principles and Practices for Public Scholarship and Teaching by Jay, Gregory

“…Will public scholarship and community engagement become central to revitalizing the humanities in the 21st century? Efforts to connect humanities research and…”
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Liquid-crystal materials find a new order in biomedical applications by Crawford, Gregory P, Woltman, Scott J, Jay, Gregory D

“…With the maturation of the information display field, liquid-crystal materials research is undergoing a modern-day renaissance. Devices and configurations…”
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Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines by Qadri, Marwa, Almadani, Sara, Jay, Gregory D, Elsaid, Khaled A

“…Osteoarthritis (OA) is a low-grade chronic inflammatory joint disease. Innate immunity contributes to OA progression, mediated by TLR2 and TLR4. We evaluated…”
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Lubricin as a Therapeutic and Potential Biomarker in Sepsis by Richendrfer, Holly, Jay, Gregory D.

“…Proteoglycan 4 (or lubricin), a mucin-like glycoprotein, was originally classified as a lubricating substance within diarthrodial joints. More recently,…”
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Prediction of anemia and estimation of hemoglobin concentration using a smartphone camera by Suner, Selim, Rayner, James, Ozturan, Ibrahim U, Hogan, Geoffrey, Meehan, Caroline P, Chambers, Alison B, Baird, Janette, Jay, Gregory D

“…Anemia, defined as a low hemoglobin concentration, has a large impact on the health of the world’s population. We describe the use of a ubiquitous device, the…”
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Prediction of anemia in real-time using a smartphone camera processing conjunctival images by Zhao, Leon, Vidwans, Alisa, Bearnot, Courtney J, Rayner, James, Lin, Timmy, Baird, Janette, Suner, Selim, Jay, Gregory D

“…Anemia is defined as a low hemoglobin (Hb) concentration and is highly prevalent worldwide. We report on the performance of a smartphone application (app) that…”
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Recombinant human PRG4 (rhPRG4) suppresses breast cancer cell invasion by inhibiting TGFβ-Hyaluronan-CD44 signalling pathway by Sarkar, Anusi, Chanda, Ayan, Regmi, Suresh C, Karve, Kunal, Deng, Lili, Jay, Gregory D, Jirik, Frank R, Schmidt, Tannin A, Bonni, Shirin

“…Metastasis is the major cause of cancer-related morbidity and mortality. The ability of cancer cells to become invasive and migratory contribute significantly…”
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The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes by Alquraini, Ali, Jamal, Maha, Zhang, Ling, Schmidt, Tannin, Jay, Gregory D, Elsaid, Khaled A

“…Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that…”
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Synergistic Interactions between Grafted Hyaluronic Acid and Lubricin Provide Enhanced Wear Protection and Lubrication by Das, Saurabh, Banquy, Xavier, Zappone, Bruno, Greene, George W, Jay, Gregory D, Israelachvili, Jacob N

“…Normal (e.g., adhesion) and lateral (friction) forces were measured between physisorbed and chemically grafted layers of hyaluronic acid (HA), an anionic…”
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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis by Waller, Kimberly A., Zhang, Ling X., Elsaid, Khaled A., Fleming, Braden C., Warman, Matthew L., Jay, Gregory D.

“…Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death,…”
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Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine–Induced Synoviocyte Proliferation by Lubricin by Al‐Sharif, Afnan, Jamal, Maha, Zhang, Ling X., Larson, Katherine, Schmidt, Tannin A., Jay, Gregory D., Elsaid, Khaled A.

“…Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44 receptor and its consequences on cytokine‐induced synoviocyte…”
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Probing the Molecular Interactions and Lubrication Mechanisms of Purified Full-Length Recombinant Human Proteoglycan 4 (rhPRG4) and Hyaluronic Acid (HA) by Huang, Jun, Qiu, Xiaoyong, Xie, Lei, Jay, Gregory D, Schmidt, Tannin A, Zeng, Hongbo

“…Probing the adsorption and lubrication behavior of lubricin, also known as proteoglycan 4 (PRG4), is important for understanding the ultralow friction of…”
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Interaction of lubricin with type II collagen surfaces: Adsorption, friction, and normal forces by Chang, Debby P, Guilak, Farshid, Jay, Gregory D, Zauscher, Stefan

“…Abstract One of the major constituents of the synovial fluid that is thought to be responsible for chondroprotection and boundary lubrication is the…”
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Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration by Qadri, Marwa, Jay, Gregory D, Zhang, Ling X, Schmidt, Tannin A, Totonchy, Jennifer, Elsaid, Khaled A

“…Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of…”
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Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice by Waller, Kimberly A, Zhang, Ling X, Jay, Gregory D

“…Deficiency of PRG4 (lubricin), the boundary lubricant in mammalian joints, contributes to increased joint friction accompanied by superficial and upper…”
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Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium by Qadri, Marwa, Jay, Gregory D, Zhang, Ling X, Richendrfer, Holly, Schmidt, Tannin A, Elsaid, Khaled A

“…Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked…”
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Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis by Teeple, Erin, Jay, Gregory D., Elsaid, Khaled A., Fleming, Braden C.

“…ABSTRACT Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of individuals worldwide. New treatment approaches require an…”
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Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis by Zhang, Minjie, Mani, Sriniwasan B, He, Yao, Hall, Amber M, Xu, Lin, Li, Yefu, Zurakowski, David, Jay, Gregory D, Warman, Matthew L

“…Joints that have degenerated as a result of aging or injury contain dead chondrocytes and damaged cartilage. Some studies have suggested that chondrocyte death…”
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Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules by Martin‐Alarcon, Leonardo, Govedarica, Aleksandra, Ewoldt, Randy H., Bryant, Steven L., Jay, Gregory D., Schmidt, Tannin A., Trifkovic, Milana

“…Synovial fluid (SF) is the complex biofluid that facilitates the exceptional lubrication of articular cartilage in joints. Its primary lubricating…”
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