Search Results - "Jay, D G"

role of lubricin in the mechanical behavior of synovial fluid by Jay, G.D, Torres, J.R, Warman, M.L, Laderer, M.C, Breuer, K.S

“…Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding…”
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Autocrine semaphorin 3A signaling promotes glioblastoma dispersal by Bagci, T, Wu, J K, Pfannl, R, Ilag, L L, Jay, D G

“…Glioblastoma multiforme (GBM) is the most malignant glioma type with diffuse borders due to extensive tumor cell infiltration. Therefore, understanding the…”
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The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model by Elsaid, K.A, Zhang, L, Shaman, Z, Patel, C, Schmidt, T.A, Jay, G.D

“…Summary Objective Study the impact of intra-articular interleukin-1 receptor antagonist (IL-1 ra) treatment on lubricin biosynthesis following anterior…”
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The Short antennae gene of Tribolium is required for limb development and encodes the orthologue of the Drosophila Distal-less protein by Beermann, A., Jay, D. G., Beeman, R. W., Hülskamp, M., Tautz, D., Jürgens, G.

“…Insects bear a stereotyped set of limbs, or ventral body appendages. In the highly derived dipteran Drosophila melanogaster, the homeodomain transcription…”
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Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts by Jay, G D, Britt, D E, Cha, C J

“…The boundary lubricating ability of human synovial fluid has been attributed to lubricin, a mucinous glycoprotein. We investigated the primary structure of…”
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Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro by Iqbal, S.M., Leonard, C., C. Regmi, S., De Rantere, D., Tailor, P., Ren, G., Ishida, H., Hsu, CY, Abubacker, S., Pang, D. SJ, T. Salo, P., Vogel, H.J., Hart, D.A., Waterhouse, C.C., Jay, G.D, Schmidt, T.A., Krawetz, R.J.

“…Proteoglycan 4 (PRG4/lubricin) is secreted by cells that reside in articular cartilage and line the synovial joint. Lubricin may play a role in modulating…”
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Randomized, prospective trial of bilevel versus continuous positive airway pressure in acute pulmonary edema by Mehta, Sangeeta, Jay, Gregory D, Woolard, Robert H, Hipona, Rene A, Connolly, Emily M, Cimini, Donna M, Drinkwine, Joseph H, Hill, Nicholas S

“…OBJECTIVE To evaluate whether bilevel positive airway pressure, by actively assisting inhalation, more rapidly improves ventilation, acidemia, and dyspnea than…”
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Early genetic restoration of lubricin expression in transgenic mice mitigates chondrocyte peroxynitrite release and caspase-3 activation by Larson, K.M., Zhang, L., Badger, G.J., Jay, G.D.

“…This study investigated the ability of endogenous lubricin secretion to restore joint health following a brief <21 day, postnatal lubricin-null state, in a…”
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Lubricin/Proteoglycan 4 Increases in both Experimental and Naturally Occurring Equine Osteoarthritis by Reesink, Heidi L., VMD, PhD, Watts, Ashlee E, Mohammed, Hussni O, Jay, Gregory D, Nixon, Alan J., BVSc, MS

“…Summary Objective The goals of this study were 1) to quantify proteoglycan4 ( PRG4 ) gene expression; 2) to assess lubricin immunostaining; and 3) to measure…”
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Chromophore-Assisted Laser Inactivation of Proteins is Mediated by the Photogeneration of Free Radicals by Liao, Joseph C., Roider, Johann, Jay, Daniel G.

“…Chromophore-assisted laser inactivation (CALI) is a technique that selectively inactivates proteins of interest to elucidate their in vivo functions. This…”
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The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection by Elsaid, K.A, Zhang, L, Waller, K, Tofte, J, Teeple, E, Fleming, B.C, Jay, G.D

“…Summary Objective To evaluate the impact of forced joint exercise following acute knee injury on lubricin metabolism and its relationship to cartilage…”
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Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix by Elsaid, K.A, Jay, G.D, Chichester, C.O

“…Objective: We have sought to determine if markers of proteoglycans and collagen type II (CII) degradation can be detected at an early stage following acute…”
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Selective Destruction of Protein Function by Chromophore-Assisted Laser Inactivation by Jay, Daniel G.

“…Chromophore-assisted laser inactivation of protein function has been achieved. After a protein binds a specific ligand or antibody conjugated with malachite…”
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The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid by Jay, G D, Cha, C J

“…To identify the boundary lubricant in synovial fluid (SF). Is synovial lubrication mediated by surface active phospholipid as opposed to mucinous glycoprotein?…”
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Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones by Wang, Feng-Song, Wolenski, Joseph S., Cheney, Richard E., Mooseker, Mark S., Jay, Daniel G.

“…The molecular mechanisms underlying directed motility of growth cones have not been determined. The role of myosin-V, an unconventional myosin, in growth cone…”
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Adhesion in hydrogel contacts by Torres, J. R., Jay, G. D., Kim, K.-S., Bothun, G. D.

“…A generalized thermomechanical model for adhesion was developed to elucidate the mechanisms of dissipation within the viscoelastic bulk of a hyperelastic…”
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Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin by Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Alweddi, Sally, Struglics, André, Rolfson, Ola, Björkman, Lena I., Kalamajski, Sebastian, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G., Eisler, Thomas

“…Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection…”
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Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin by Chang, Howard Y, Takei, Kohtaro, Sydor, Anne M, Born, Timothy, Rusnak, Frank, Jay, Daniel G

“…The neuronal growth cone is thought to be the site of decision making in nerve growth and guidance. One likely mechanism of how the growth cone translates…”
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Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury by Elsaid, K. A., Fleming, B. C., Oksendahl, H. L., Machan, J. T., Fadale, P. D., Hulstyn, M. J., Shalvoy, R., Jay, G. D.

“…Objective To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time…”
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Talin and Vinculin Play Distinct Roles in Filopodial Motility in the Neuronal Growth Cone by Sydor, Anne M., Su, Anne L., Wang, Feng-Song, Xu, Alian, Jay, Daniel G.

“…Filopodial motility is critical for many biological processes, particularly for axon guidance. This motility is based on altering the F-actin-based…”
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