Search Results - "Jaworski, Deborah"

Genetically modified live vaccine offers protective immunity against wild-type Anaplasma marginale tick-transmission challenge by Ferm, Jonathan, Jaworski, Deborah C., Stoll, Ian, Kleinhenz, Michael D., Kocan, Katherine M., Madesh, Swetha, Ferm, Dominica, Liu, Huitao, Fitzwater, Shawna, Schlieper, Alexis, Ganta, Roman R.

“…•Anaplasma marginale causes the economically important tick-borne disease in cattle; bovine anaplasmosis. Vaccines have had limited efficacy in preventing this…”
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Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host by McGill, Jodi L, Nair, Arathy D S, Cheng, Chuanmin, Rusk, Rachel A, Jaworski, Deborah C, Ganta, Roman R

“…Ehrlichia chaffeensis is a tick-borne rickettsial pathogen and the causative agent of human monocytic ehrlichiosis. Transmitted by the Amblyomma americanum…”
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Mutations in Ehrlichia chaffeensis Causing Polar Effects in Gene Expression and Differential Host Specificities by Cheng, Chuanmin, Nair, Arathy D S, Jaworski, Deborah C, Ganta, Roman R

“…Ehrlichia chaffeensis, a tick-borne rickettsial, is responsible for human monocytic ehrlichiosis. In this study, we assessed E. chaffeensis insertion mutations…”
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Ehrlichia chaffeensis infection in the reservoir host (white-tailed deer) and in an incidental host (dog) is impacted by its prior growth in macrophage and tick cell environments by Nair, Arathy D S, Cheng, Chuanmin, Jaworski, Deborah C, Willard, Lloyd H, Sanderson, Michael W, Ganta, Roman R

“…Ehrlichia chaffeensis, transmitted from Amblyomma americanum ticks, causes human monocytic ehrlichiosis. It also infects white-tailed deer, dogs and several…”
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Multiple Ehrlichia chaffeensis genes critical for persistent infection in a vertebrate host are identified as nonessential for its growth in the tick vector; Amblyomma americanum by Jaworski, Deborah C, Wang, Ying, Nair, Arathy, Liu, Huitao, Ganta, Roman R

“…is a tick-transmitted monocytic ehrlichiosis agent primarily causing the disease in people and dogs. We recently described the development and characterization…”
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Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with In Vivo Infection Assessment by Wang, Ying, Nair, Arathy D S, Alhassan, Andy, Jaworski, Deborah C, Liu, Huitao, Trinkl, Kathleen, Hove, Paidashe, Ganta, Charan K, Burkhardt, Nicole, Munderloh, Ulrike G, Ganta, Roman R

“…, a tick-transmitted obligate intracellular rickettsial agent, causes human monocytic ehrlichiosis. In recent reports, we described substantial advances in…”
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Targeted mutagenesis in Anaplasma marginale to define virulence and vaccine development against bovine anaplasmosis by Hove, Paidashe, Madesh, Swetha, Nair, Arathy, Jaworski, Deborah, Liu, Huitao, Ferm, Jonathan, Kleinhenz, Michael D, Highland, Margaret A, Curtis, Andrew K, Coetzee, Johann F, Noh, Susan M, Wang, Ying, Genda, Dominica, Ganta, Roman R

“…Tick-borne Anaplasma species are obligate, intracellular, bacterial pathogens that cause important diseases globally in people, agricultural animals, and dogs…”
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Long-Term Protective Immunity against Ehrlichia chaffeensis Infection Induced by a Genetically Modified Live Vaccine by Madesh, Swetha, McGill, Jodi, Jaworski, Deborah C, Ferm, Jonathan, Liu, Huitao, Fitzwater, Shawna, Hove, Paidashe, Ferm, Dominica, Nair, Arathy, Knox, Cheyenne A, Alizadeh, Kimia, Thackrah, Ashley, Ganta, Roman R

“…Human monocytic ehrlichiosis, an emerging tick-borne disease, is caused by . Infections with the pathogen are also common in the canine host. Our previous…”
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Attenuated Mutants of Ehrlichia chaffeensis Induce Protection against Wild-Type Infection Challenge in the Reservoir Host and in an Incidental Host by Nair, Arathy D S, Cheng, Chuanmin, Jaworski, Deborah C, Ganta, Suhasini, Sanderson, Michael W, Ganta, Roman R

“…Ehrlichia chaffeensis, a tick-borne rickettsial organism, causes the disease human monocytic ehrlichiosis. The pathogen also causes disease in several other…”
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Targeted and random mutagenesis of Ehrlichia chaffeensis for the identification of genes required for in vivo infection by Cheng, Chuanmin, Nair, Arathy D S, Indukuri, Vijaya V, Gong, Shanzhong, Felsheim, Roderick F, Jaworski, Deborah, Munderloh, Ulrike G, Ganta, Roman R

“…Ehrlichia chaffeensis is a tick transmitted pathogen responsible for the disease human monocytic ehrlichiosis. Research to elucidate gene function in…”
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Amblyomma americanum ticks infected with in vitro cultured wild-type and mutants of Ehrlichia chaffeensis are competent to produce infection in naïve deer and dogs by Jaworski, Deborah C, Cheng, Chuanmin, Nair, Arathy D S, Ganta, Roman R

“…Monocytic ehrlichiosis in people caused by the intracellular bacterium, Ehrlichia chaffeensis, is an emerging infectious disease transmitted by the lone star…”
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The transcriptome of the lone star tick, Amblyomma americanum, reveals molecular changes in response to infection with the pathogen, Ehrlichia chaffeensis by Kim, Donghun, Jaworski, Deborah C., Cheng, Chuanmin, Nair, Arathy D.S., Ganta, Roman R., Herndon, Nic, Brown, Susan, Park, Yoonseong

“…The lone star tick, Amblyomma americanum, is an obligatory ectoparasite of many vertebrates and the primary vector of Ehrlichia chaffeensis, the causative…”
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Dermacentor variabilis: Characterization and modeling of macrophage migration inhibitory factor with phylogenetic comparisons to other ticks, insects and parasitic nematodes by Wasala, Nalinda B., Jaworski, Deborah C.

“…A schematic presentation of the results from the consurf analysis to find the conserved amino acids in the homology model for D. variabilis MIF. (A) Stick…”
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A white-tailed deer/lone star tick model for studying transmission of Ehrlichia chaffeensis by Jaworski, Deborah C, Bowen, C Jerry, Wasala, Nalinda B

“…Animal models for Ehrlichia chaffeensis have been unsuccessful in recapitulating the natural disease cycle. We have developed an animal model for tick feeding…”
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Expression and regulation of macrophage migration inhibitory factor (MIF) in feeding American dog ticks, Dermacentor variabilis by Wasala, Nalinda B, Bowen, C. J, Jaworski, Deborah C

“…Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine produced by many mammalian tissues. It is also found in ticks and may function to…”
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) by Heerding, Dirk A, Chan, George, DeWolf, Walter E, Fosberry, Andrew P, Janson, Cheryl A, Jaworski, Deborah D, McManus, Edward, Miller, William H, Moore, Terrance D, Payne, David J, Qiu, Xiayang, Rittenhouse, Stephen F, Slater-Radosti, Courtney, Smith, Ward, Takata, Dennis T, Vaidya, Kalindi S, Yuan, Catherine C.K, Huffman, William F

“…1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal…”
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Tick ‘talk’: protein release by tick salivary cells by Jaworski, Deborah C.

“…Tick salivary gland proteins involved in exocytosis via soluble N-ethylmaleimide sensitive factor attachment proteins (SNAPs) and their receptor proteins…”
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens by JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela

“…Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized…”
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Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus by Slater-Radosti, Courtney, Van Aller, Glenn, Greenwood, Rebecca, Nicholas, Richard, Keller, Paul M., DeWolf, Walter E., Fan, Frank, Payne, David J., Jaworski, Deborah D.

“…Triclosan, a widely used antibacterial agent, possesses potent activity against Staphylococcus aureus. This study reports on an investigation of the…”
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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents by Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, DeWolf, Walter E, Keller, Paul M, Qiu, Xiayang, Janson, Cheryl A, Vaidya, Kalindi, Fosberry, Andrew P, Smyth, Martin G, Jaworski, Deborah D, Slater-Radosti, Courtney, Huffman, William F

“…An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as inhibitors of Staphylococcus…”
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