Search Results - "Javed, Kiran"

Quantitative modelling of amino acid transport and homeostasis in mammalian cells by Gauthier-Coles, Gregory, Vennitti, Jade, Zhang, Zhiduo, Comb, William C., Xing, Shuran, Javed, Kiran, Bröer, Angelika, Bröer, Stefan

“…Homeostasis is one of the fundamental concepts in physiology. Despite remarkable progress in our molecular understanding of amino acid transport, metabolism…”
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Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption by Javed, Kiran, Bröer, Stefan

“…Dietary protein restriction has beneficial impacts on metabolic health. B AT1 (SLC6A19) is the major transporter of neutral amino acids at the intestinal…”
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Comparison of postoperative hypersensitivity between Total-etch and Universal adhesive system: a randomized clinical trial by Javed, Kiran, Noor, Nouman, Nasir, Muhammad Zubair, Manzoor, Manzoor Ahmed

“…The objective was to determine the postoperative hypersensitivity of two-step Total-etch as compared to one-step Universal adhesives followed by composite…”
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Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii by Fairweather, Stephen J, Rajendran, Esther, Blume, Martin, Javed, Kiran, Steinhöfel, Birte, McConville, Malcolm J, Kirk, Kiaran, Bröer, Stefan, van Dooren, Giel G

“…Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large…”
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Role of diet and dietary habits in causing dental caries among adults reporting to a tertiary care hospital in Pakistan; a case-control study by Javed, Kiran, Nasir, Muhammad Zubair, Jalees, Maham, Manzoor, Manzoor Ahmed

“…To determine the association of diet and dietary practices with dental caries among adults. A case-control study. Operative Department, Rawal Institute of…”
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Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases by Yadav, Aditya, Shah, Nishank, Tiwari, Praveen Kumar, Javed, Kiran, Cheng, Qi, Aidhen, Indrapal Singh, Bröer, Stefan

“…Lack of B 0 AT1 (SLC6A19) partially protects mice against the onset of non-alcoholic steatohepatitis (NASH). To achieve a similar outcome through…”
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Development of Biomarkers for Inhibition of SLC6A19 (B⁰AT1)-A Potential Target to Treat Metabolic Disorders by Javed, Kiran, Cheng, Qi, Carroll, Adam J, Truong, Thy T, Bröer, Stefan

“…Recent studies have established that dietary protein restriction improves metabolic health and glucose homeostasis. SLC6A19 (B⁰AT1) is the major neutral amino…”
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A GC-MS/Single-Cell Method to Evaluate Membrane Transporter Substrate Specificity and Signaling by Fairweather, Stephen J, Okada, Shoko, Gauthier-Coles, Gregory, Javed, Kiran, Bröer, Angelika, Bröer, Stefan

“…Amino acid transporters play a vital role in metabolism and nutrient signaling pathways. Typically, transport activity is investigated using single substrates…”
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Learning Active Implementation Frameworks: the role of implementation teams in a case study from Pakistan by Hamid, Saima, Mureed, Sheh, Kayani, Aasia, Javed, Kiran, Khan, Adnan, Awais, Sayema, Khan, Neelam, Tus-Salam, Fakiha, Fixsen, Dean L.

“…In Pakistan, although coverage of Maternal, Newborn, and Child Health (MNCH) services has increased, the attributable disease burden remains high, indicating…”
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Knockout of the Amino Acid Transporter SLC6A19 and Autoimmune Diabetes Incidence in Female Non-Obese Diabetic (NOD) Mice by Waters, Matthew F., Delghingaro-Augusto, Viviane, Javed, Kiran, Dahlstrom, Jane E., Burgio, Gaetan, Bröer, Stefan, Nolan, Christopher J.

“…High protein feeding has been shown to accelerate the development of type 1 diabetes in female non-obese diabetic (NOD) mice. Here, we investigated whether…”
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Platelets Bind Senescent Red Blood Cells and Mediate Their Clearance from the Circulation by McMorran, Brendan J., Ningtyas, Dian C, Leitner, Florentina, Javed, Kiran, Sawbridge, Megan, Hicks, Sarah M, Thong, Yee Lin, Lee, Jiwon, Rug, Melanie, Choi, Philip Y., Coupland, Lucy, Gardiner, Elizabeth E.

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Platelets mediate the clearance of senescent red blood cells by forming prophagocytic platelet-cell complexes by Ningtyas, Dian C., Leitner, Florentina, Sohail, Huma, Thong, Yee Lin, Hicks, Sarah M., Ali, Sidra, Drew, Megan, Javed, Kiran, Lee, Jiwon, Kenangalem, Enny, Poespoprodjo, Jeanne R., Anstey, Nicholas M., Rug, Melanie, Choi, Philip Y.-I., Kho, Steven, Gardiner, Elizabeth E., McMorran, Brendan J.

“…•Senescent RBCs are bound to platelets, forming P-RBC complexes that are selectively consumed by erythrophagocytes.•A sufficient supply of platelets is…”
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Platelets mediate the clearance of senescent red blood cells by forming pro-phagocytic platelet-cell complexes by Ningtyas, Dian Citra, Leitner, Florentina, Sohail, Huma, Thong, Yee Lin, Hicks, Sarah M, Ali, Sidra Asad, Drew, Megan E, Javed, Kiran, Lee, Jiwon, Kenangalem, Enny, Poespoprodjo, Jeanne Rini, Anstey, Nicholas Mark, Rug, Melanie, Choi, Philip Y, Kho, Steven, Gardiner, Elizabeth E, McMorran, Brendan J

“…In humans approximately 0.1-0.3% of circulating red blood cells (RBC) are present as platelet-RBC (P-RBC) complexes, and 1-2% in mice. Excessive P-RBC…”
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DISTRIBUTIONOF URINARY TRACT INFECTIONS BY SEX, AGE GROUP AND TYPE OF BACTERIA IN POPULATION OF ISLAMABAD, PAKISTAN by Zahideen, Zahid Ul, Ullah, Ubed, Ullah, Imran, Javed, Kiran, Azra, Syeda

“…Background: Urinary tract infections (UTIs) are common bacterial infections leading to significant morbidity, hospital admissions and cost. Our objectives were…”
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Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B 0 AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases by Yadav, Aditya, Shah, Nishank, Tiwari, Praveen Kumar, Javed, Kiran, Cheng, Qi, Aidhen, Indrapal Singh, Bröer, Stefan

“…Lack of B AT1 (SLC6A19) partially protects mice against the onset of non-alcoholic steatohepatitis (NASH). To achieve a similar outcome through pharmacological…”
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Development of biomarkers for protein malabsorption and in vivo inhibition of B0AT1(SLC6A19) by Javed, Kiran, Carroll, Adam, Thruong, Thy, Broer, Stefan

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PREVALENCE, DISTRIBUTION AND DETERMINANTS OF ESCHERICHIA COLI RESISTANCE TO CEFTRIAXONE IN ADULT INDOOR UTI POPULATION OF DISTRICT PESHAWAR, PAKISTAN by Ullah, Ubed, Javed, Kiran, Khan, Muhammad Asim, Ullah, Imran, Iman, Noor Ul

“…Background: Escherichia coliresistance to ceftriaxone in UTIs is an emerging health problem.Our objectives were to determine prevalence, distribution and…”
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Disrupting amino acid homeostasis to improve metabolic diseases by Broer, Stefan, Cheng, Qi, Shah, Nishank, Javed, Kiran, Yadav, Aditya, Brachs, Sebastian, Spranger, Joachim, Zhang, Jianhua

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Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma by Xiong, Jun-Jie, Altaf, Kiran, Javed, Muhammad A, Huang, Wei, Mukherjee, Rajarshi, Mai, Gang, Sutton, Robert, Liu, Xu-Bao, Hu, Wei-Ming

“…AIM：To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection（LLR） and open liver resection（OLR） for hepatocellular…”
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