A systematic review and meta-analysis on the influence of biological implant surface coatings on periimplant bone formation

A systematic review and meta-analysis on the influence of biological implant surface coatings on periimplant bone formation

This systematic review and meta‐analysis evaluated the influence of biological implant surface coatings on periimplant bone formation in comparison to an uncoated titanium reference surface in experimental large animal models. The analysis was structured according to the PRISMA criteriae. Of the1077...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A Vol. 104; no. 11; pp. 2898 - 2910
Main Authors: Jenny, Gregor, Jauernik, Johanna, Bierbaum, Susanne, Bigler, Martin, Grätz, Klaus W., Rücker, Martin, Stadlinger, Bernd
Format: Journal Article
Language:English
Published: United States Blackwell Publishing Ltd 01-11-2016
Wiley Subscription Services, Inc
Subjects:
animal experiments
Animal models
Animals
Biocompatibility
bone implant interactions
Bone Substitutes - chemistry
Bone Substitutes - metabolism
Chemical industry
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - metabolism
Coating effects
Coatings
dental implant
Electrochemical machining
Extracellular matrix
histomorphometry
Implants, Experimental
Intercellular Signaling Peptides and Proteins - chemistry
Intercellular Signaling Peptides and Proteins - metabolism
Meta-analysis
Osteogenesis
Reviews
Statistical analysis
Statistics
surface coatings complexes
Surface Properties
Surgical implants
Titanium
Titanium - chemistry
Titanium - metabolism
animal experiments
histomorphometry
surface coatings complexes
bone implant interactions
dental implant
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Summary:This systematic review and meta‐analysis evaluated the influence of biological implant surface coatings on periimplant bone formation in comparison to an uncoated titanium reference surface in experimental large animal models. The analysis was structured according to the PRISMA criteriae. Of the1077 studies, 30 studies met the inclusion criteriae. Nineteen studies examined the bone implant contact (BIC) and were included in the meta‐analysis. Overall, the mean increase in BIC for the test surfaces compared to the reference surfaces was 3.7 percentage points (pp) (95% CI −3.9–11.2, p = 0.339). Analyzing the increase in BIC for specific coated surfaces in comparison to uncoated reference surfaces, inorganic surface coatings showed a significant mean increase in BIC of 14.7 pp (95% CI 10.6–18.9, p < 0.01), extracellular matrix (ECM) surface coatings showed an increase of 10.0 pp (95% CI 4.4–15.6, p < 0.001), and peptide coatings showed a statistical trend with 7.1 pp BIC increase (95% CI −0.8–15.0, p = 0.08). In this review, no statistically significant difference could be found for growth factor surface coatings (observed difference −3.3 pp, 95% CI −16.5–9.9, p = 0.6). All analyses are exploratory in nature. The results show a statistically significant effect of inorganic and ECM coatings on periimplant bone formation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2898–2910, 2016.
Bibliography:ArticleID:JBMA35805
istex:CA1B8010AF42AA9B1794B5BCC95BA0A5EDEFFB1D
ark:/67375/WNG-4WNRP84C-Z
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.35805