Complex, multimodal behavioral profile of the Homer1 knockout mouse

Proteins of the Homer1 immediate early gene family have been associated with synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss of function. This study examined the behavior of male Homer1 knockout (KO) mice compared with wild‐type (WT) and heterozygous mice usin...

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Bibliographic Details
Published in:	Genes, brain and behavior Vol. 6; no. 2; pp. 141 - 154
Main Authors:	Jaubert, P. J., Golub, M. S., Lo, Y. Y., Germann, S. L., Dehoff, M. H., Worley, P. F., Kang, S. H., Schwarz, M. K., Seeburg, P. H., Berman, R. F.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-03-2007
Subjects:	Analysis of Variance Animals Behavior Behavior, Animal - physiology Body Size - genetics Carrier Proteins - genetics Carrier Proteins - physiology Food Preferences - physiology Heterozygote Hippocampus - metabolism Homer Scaffolding Proteins Homer1 Imitative Behavior knockout learning Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Knockout Motor Skills - physiology Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Rotarod Performance Test Social Behavior social interaction Species Specificity
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Summary:	Proteins of the Homer1 immediate early gene family have been associated with synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss of function. This study examined the behavior of male Homer1 knockout (KO) mice compared with wild‐type (WT) and heterozygous mice using a battery of 10 behavioral tests probing sensory, motor, social, emotional and learning/memory functions. KO mice showed mild somatic growth retardation, poor motor coordination, enhanced sensory reactivity and learning deficits. Heterozygous mice showed increased aggression in social interactions with conspecifics. The distribution of mGluR5 and N‐methyl‐d‐aspartate receptors (NMDA) receptors appeared to be unaltered in the hippocampus (HIP) of Homer1 KO mice. The results indicate an extensive range of disrupted behaviors that should contribute to the understanding of the Homer1 gene in brain development and behavior.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1601-1848 1601-183X
DOI:	10.1111/j.1601-183X.2006.00240.x