Efficacy and safety of a novel water‐soluble herbal patch for acne vulgaris treatment: A randomized, assessor‐blinds controlled, intra‐individual split‐face comparative study

Acne vulgaris is a chronic inflammatory skin disease. Antibiotics, particularly clindamycin and erythromycin, are used for the treatment of acne vulgaris. However, emerging antibiotic‐resistant strains have been an important problem. This study aims to evaluate the efficiency and safety of a novel w...

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Bibliographic Details
Published in:	Dermatologic therapy Vol. 34; no. 3; pp. e14925 - n/a
Main Authors:	Jaturapisanukul, Kulwipapat, Udompataikul, Montree, Kanokrungsee, Silada, Rojhirunsakool, Salinee, Kamanamool, Nanticha, Rachpirom, Mingkwan, Puttarak, Panupong
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01-05-2021
Subjects:	acne vulgaris herbal acne patch hydrocolloid patch inflammation treatment acne vulgaris treatment herbal acne patch inflammation hydrocolloid patch
Online Access:	Get full text
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Summary:	Acne vulgaris is a chronic inflammatory skin disease. Antibiotics, particularly clindamycin and erythromycin, are used for the treatment of acne vulgaris. However, emerging antibiotic‐resistant strains have been an important problem. This study aims to evaluate the efficiency and safety of a novel water‐soluble herbal acne patch (WHAP) compared with the hydrocolloid acne patch (HAP) in mild to moderate inflammatory acne patients. The randomized, assessor‐blind controlled, intra‐individual split‐face study was performed on 49 acne patients. The clinical outcomes were evaluated on day 2, 4, 7, 9, and 11 of treatment. It was shown that the median time to resolution of the inflammatory acne treated with WHAP was shorter than HAP with a statistically significant difference (WHAP was 4 days, whereas HAP was 6 days) (P value <.001). Moreover, WHAP had a more significant decrease in the rate of inflammatory diameter, erythema scores (by clinical and colorimetry), and a more increase in the rate of lightness scores (by colorimetry) than HAP (P value <.05). No adverse effects were reported in both groups. It is safe to use WHAP as an alternative treatment for inflammatory acne.
Bibliography:	Funding information Industrial Research and Technology Capacity Development Program (IRTC), Thailand, Grant/Award Number: IRTC‐PSU63‐06 Correction added on 27 April after first online publication: the author surname was change from Kanolrungsee to Kanokrungsee ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	1396-0296 1529-8019
DOI:	10.1111/dth.14925