Protective role of Anacardium occidentale extract against streptozotocin-induced diabetes in rats

The protective effect of Anacardium occidentale aqueous extract against streptozotocin-induced diabetes was evaluated in rats. The rats were treated with 175 mg/kg of the extract per os, twice daily; beginning 2 days before streptozotocin (STZ) injection. A total of 3 days after STZ administration,...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 62; no. 2; pp. 95 - 99
Main Authors:	Kamtchouing, Pierre, Sokeng, Selestin D, Moundipa, Paul F, Watcho, Pierre, Jatsa, Hermine B, Lontsi, David
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-09-1998 Elsevier
Subjects:	Anacardium occidentale Animals Biological and medical sciences Blood Glucose - analysis Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - prevention & control experimental diabetes General pharmacology Male Medical sciences medicinal plants Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal - chemistry Rats Rats, Wistar Streptozocin Streptozotocin traditional medicine Cameroon Africa Rats Anacardium occidentale Streptozotocin Diabetes mellitus Endocrinopathy Rat Pharmacognosy Rodentia Oral administration Extract Medicinal plant Prevention Vertebrata Mammalia Folk medicine Dicotyledones Animal Angiospermae Plant origin Spermatophyta Phytotherapy Anacardiaceae
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Summary:	The protective effect of Anacardium occidentale aqueous extract against streptozotocin-induced diabetes was evaluated in rats. The rats were treated with 175 mg/kg of the extract per os, twice daily; beginning 2 days before streptozotocin (STZ) injection. A total of 3 days after STZ administration, there was a 48% increase in blood glucose level in pretreated rats, compared with a 208% increase in diabetic control rats treated with STZ alone. Furthermore, these pretreated animals presented no glycosuria, a normal weight gain and a non significant increase in food and fluid intake at the end of the treatment compared with the normal control. Diabetic control animals showed a positive glycosuria, body weight loss, a real polyphagia and polydypsia. These results indicate the protective role of Anacardium occidentale extract against the diabetogenic action of STZ.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0378-8741 1872-7573
DOI:	10.1016/S0378-8741(97)00159-1