Search Results - "Jatkar, Aditi"
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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice
Published in Cell metabolism (02-05-2017)“…The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal…”
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2
Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism
Published in Calcified tissue international (01-01-2017)“…Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we…”
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Phenotyping hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable isotope tracing
Published in Analytical biochemistry (01-09-2016)“…Metabolite stable isotope tracing is a powerful bioanalytical strategy that has the potential to unravel phenotypic markers of early pharmaceutical efficacy by…”
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4
Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Published in Nature medicine (01-04-2018)“…In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the…”
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Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Published in Nature medicine (01-09-2018)“…In the version of this article initially published, the “[13C2]α-ketoglutarate” label on Fig. 1g is incorrect. It should be “[13C5]α-ketoglutarate”…”
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Selective Activation of AMPK β 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy
Published in The Journal of pharmacology and experimental therapeutics (01-05-2017)“…Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A…”
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P4–300: Developing an in vitro‐in vivo model to study the impact of increasing brain APOE levels on cardiovascular safety
Published in Alzheimer's & dementia (01-07-2013)Get full text
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Developing an in vitro - in vivo model to study the impact of increasing brain APOE levels on cardiovascular safety
Published in Alzheimer's & dementia (01-07-2013)Get full text
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Whole body vibration as a treatment to counter bone detriment and obesity caused by poor nutritional intake
Published 01-01-2010“…Consumption of diets high in fat content or carbohydrate content is known to cause obesity and diabetes. In fact the causes and effects of diabetes and obesity…”
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Dissertation