Search Results - "Jasti, Vijay P"

Replicative bypass of abasic site in Escherichia coli and human cells: similarities and differences by Weerasooriya, Savithri, Jasti, Vijay P, Basu, Ashis K

“…Abasic [apurinic/apyrimidinic (AP)] sites are the most common DNA damages, opposite which dAMP is frequently inserted ('A-rule') in Escherichia coli…”
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Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4 by Pednekar, Varsha, Weerasooriya, Savithri, Jasti, Vijay P, Basu, Ashis K

“…Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine…”
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Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model by Weng, Mao-wen, Zheng, Yi, Jasti, Vijay P, Champeil, Elise, Tomasz, Maria, Wang, Yinsheng, Basu, Ashis K, Tang, Moon-shong

“…Mitomycin C induces both MC-mono-dG and cross-linked dG-adducts in vivo. Interstrand cross-linked (ICL) dG-MC-dG-DNA adducts can prevent strand separation. In…”
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(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli by Jasti, Vijay P, Das, Rajat S, Hilton, Benjamin A, Weerasooriya, Savithri, Zou, Yue, Basu, Ashis K

“…8,5′-Cyclopurines, making up an important class of ionizing radiation-induced tandem DNA damage, are repaired only by nucleotide excision repair (NER). They…”
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Interconversion of the cis-5R,6S- and trans-5R,6R-Thymine Glycol Lesions in Duplex DNA by Brown, Kyle L, Adams, Travis, Jasti, Vijay P, Basu, Ashis K, Stone, Michael P

“…Thymine glycol (Tg), 5,6-dihydroxy-5,6-dihydrothymine, is formed in DNA by the reaction of thymine with reactive oxygen species. The 5R Tg lesion was…”
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Mechanistic Studies of the Bypass of a Bulky Single-base Lesion Catalyzed by a Y-family DNA Polymerase by Sherrer, Shanen M., Brown, Jessica A., Pack, Lindsey R., Jasti, Vijay P., Fowler, Jason D., Basu, Ashis K., Suo, Zucai

“…1-Nitropyrene, the most abundant nitro polycyclic aromatic hydrocarbon in diesel emissions, has been found to react with DNA to form predominantly…”
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Mutational Analysis of the C8-Guanine Adduct of the Environmental Carcinogen 3‑Nitrobenzanthrone in Human Cells: Critical Roles of DNA Polymerases η and κ and Rev1 in Error-Prone Translesion Synthesis by Pande, Paritosh, Malik, Chanchal K, Bose, Arindam, Jasti, Vijay P, Basu, Ashis K

“…3-Nitrobenzanthrone (3-NBA), a potent mutagen and suspected human carcinogen, is a common environmental pollutant. The genotoxicity of 3-NBA has been…”
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Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O 2-alkylthymidines in human cells by Weerasooriya, Savithri, Jasti, Vijay P, Bose, Arindam, Spratt, Thomas E, Basu, Ashis K

“…The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent human carcinogen. Metabolic activation of NNK generates a…”
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DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cells by Bose, Arindam, Pande, Paritosh, Jasti, Vijay P, Millsap, Amy D, Hawkins, Edward K, Rizzo, Carmelo J, Basu, Ashis K

“…The roles of translesion synthesis (TLS) DNA polymerases in bypassing the C8-2'-deoxyguanosine adduct (dG-C8-IQ) formed by…”
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Tobacco-Specific Nitrosamine-Derived O 2-Alkylthymidines Are Potent Mutagenic Lesions in SOS-Induced Escherichia coli by Jasti, Vijay P, Spratt, Thomas E, Basu, Ashis K

“…To investigate the biological effects of the O 2-alkylthymidines induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone…”
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Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells by Weerasooriya, Savithri, Jasti, Vijay P., Bose, Arindam, Spratt, Thomas E., Basu, Ashis K.

“…[Display omitted] •O2-Me-dT and O2-POB-dT are replication blocking and highly mutagenic lesions in human cells•Both O2-Me-dT and O2-POB-dT induce T→A as the…”
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Tobacco-specific nitrosamine-derived O2-alkylthymidines are potent mutagenic lesions in SOS-induced Escherichia coli by Jasti, Vijay P, Spratt, Thomas E, Basu, Ashis K

“…To investigate the biological effects of the O(2)-alkylthymidines induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone…”
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Tobacco-Specific Nitrosamine-Derived O super(2)-Alkylthymidines Are Potent Mutagenic Lesions in SOS-Induced Escherichia coli by Jasti, Vijay P, Spratt, Thomas E, Basu, Ashis K

“…To investigate the biological effects of the O super(2)-alkylthymidines induced by the tobacco-specific nitrosamine…”
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Abstract 1328: Replication inhibition and mutagenicity of 8,5’-cyclopurine-2’-deoxynucleosides in Escherichia coli by Basu, Ashis K., Jasti, Vijay P., Das, Rajat S., Weerasooriya, Savithri

“…8,5’-Cyclopurine-2’-deoxynucleosides are unique tandem DNA lesions formed by oxidation or ionizing radiation, which are repaired only by nucleotide excision…”
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Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences: e107915 by Weerasooriya, Savithri, Jasti, Vijay P, Basu, Ashis K

“…Abasic [apurinic/apyrimidinic (AP)] sites are the most common DNA damages, opposite which dAMP is frequently inserted ('A-rule') in Escherichia coli…”
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Interconversion of the cis -5 R ,6 S - and trans -5 R ,6 R -Thymine Glycol Lesions in Duplex DNA by Brown, Kyle L., Adams, Travis, Jasti, Vijay P., Basu, Ashis K., Stone, Michael P.

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Interconversion of the cis-5R,6S- and trans-5R,6R-Thym ine Glycol Lesions in Duplex DNA by Brown, Kyle L, Adams, Travis, Jasti, Vijay P, Basu, Ashis K, Stone, Michael P

“…Thymine glycol (Tg), 5,6-dihydroxy-5,6-dihydrothymine, is formed in DNA by the reaction of thymine with reactive oxygen species. The 5R Tg lesion was…”
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Abstract 1967: UvrABC excision of interstrand crosslink mitomycin C-DNA lesion induces double-stranded DNA breaks by Weng, Mao Wen, Zheng, Yi, Jasti, Vijay P., Champeil, Elise, Tomasz, Maria, Wang, Yin sheng, Basu, Ashis K., Tang, Moon Shong

“…Mitomycin C (MC) forms at least nine different covalent DNA adducts including an N2-2’-deoxyguanosine monoadduct (MC-mono-dG) and inter- and intrastrand…”
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Mechanistic Studies of the Bypass of a Bulky Single-base Lesion Catalyzed by a Y-family DNA PolymeraseS by Sherrer, Shanen M., Brown, Jessica A., Pack, Lindsey R., Jasti, Vijay P., Fowler, Jason D., Basu, Ashis K., Suo, Zucai

“…1-Nitropyrene, the most abundant nitro polycyclic aromatic hydrocarbon in diesel emissions, has been found to react with DNA to form predominantly N…”
Get full text