Enhanced antimicrobial activity of naturally derived bioactive molecule chitosan conjugated silver nanoparticle against dental implant pathogens

Various metal coated implants have been tested against dental pathogens which causes increased biofilm formation and lead to failure of dental implants. The possibility of using nanoparticle together with native biomolecules to enhance the activity of such bioactive compound is also in progress. In...

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Bibliographic Details
Published in:	International journal of biological macromolecules Vol. 108; pp. 790 - 797
Main Authors:	Divakar, Darshan Devang, Jastaniyah, Nahla Talal, Altamimi, Hazem Ganem, Alnakhli, Yasser Obaidallah, Muzaheed, Alkheraif, Abdulaziz Abdullah, Haleem, Shaista
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-03-2018
Subjects:	Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Bacteria - drug effects Bacterial Adhesion - drug effects Bioactive molecule Biofilm Biofilms - drug effects Biological Products - chemistry Biological Products - pharmacology Cell Line Cell Survival - drug effects Chitosan Chitosan - chemistry Chitosan - pharmacology Dental Implants - microbiology Humans Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microbial Sensitivity Tests Nanoparticles Silver - chemistry Silver - pharmacology Titanium Titanium dental implant Nanoparticles Biofilm Bioactive molecule Titanium dental implant Chitosan Ag
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Summary:	Various metal coated implants have been tested against dental pathogens which causes increased biofilm formation and lead to failure of dental implants. The possibility of using nanoparticle together with native biomolecules to enhance the activity of such bioactive compound is also in progress. In this study we tested the efficacy of Ag conjugated chitosan nanoparticles as a prospective coating material of titanium dental implants. Known bioactive molecule chitosan was extracted from A. flavus Af09 and conjugated with Ag nanoparticle. Fully characterized Ag-chitosan nanoparticle had a sound inhibitory effect on the growth of two major dental pathogens S. mutans and P. gingivalis. It not only inhibits the adhesion of these two tested bacteria but also able to reduce the biofilm formation. Apart from this, nanoparticle was also able to inhibit the QS production in bacteria tested in this study. Naturally extracted chitosan has been known for its antibacterial activity for a different group of bacteria. Nanoparticles are the good option to enhance the biocompatibility. No cell cytotoxicity of nanoparticle indicates its biocompatibility and coating of titanium dental implants with Ag-chitosan may have an added advantage on the corrosion resistance of dental implants and also augments the passivating effect of these implants.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2017.10.166