Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study

Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study

To describe the effect of diabetes mellitus (DM) on clinical outcomes of patients admitted with COVID-19 infection. We carried out a single center, observational, retrospective study. We included adult patients with laboratory-confirmed diagnosis of COVID-19 admitted to a tertiary hospital in Jeddah...

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Bibliographic Details
Published in:Saudi medical journal Vol. 44; no. 1; pp. 67 - 73
Main Authors: Sindi, Anees A, Tashkandi, Wail A, Jastaniah, Mohammed W, Bashanfar, Mohammed A, Fakhri, Ahmed F, Alsallum, Fahad S, Alguydi, Hamdan B, Elhazmi, Alyaa, Al-Khatib, Talal A, Alawi, Maha M, Abushoshah, Ibrahim
Format: Journal Article
Language:English
Published: Saudi Arabia Saudi Medical Journal 01-01-2023
Subjects:
Adult
Aged
China
Chronic kidney failure
Comorbidity
Comparative analysis
COVID-19
Diabetes
Diabetes Mellitus - epidemiology
Diabetics
Female
Heart diseases
Humans
Hypertension
Male
Medical research
Medicine, Experimental
Middle Aged
Morbidity
Mortality
Original
Patient outcomes
Retrospective Studies
SARS-CoV-2
Saudi Arabia
Saudi Arabia
China
COVID-19
SARS-CoV-2
diabetes mellitus
HbA1c
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Summary:To describe the effect of diabetes mellitus (DM) on clinical outcomes of patients admitted with COVID-19 infection. We carried out a single center, observational, retrospective study. We included adult patients with laboratory-confirmed diagnosis of COVID-19 admitted to a tertiary hospital in Jeddah, Saudi Arabia, from April 2020 to December 2020. Electronic medical records were reviewed for demographics, clinical status, hospital course, and outcome; and they were compared between the patients with or without DM. Out of 198 patients included in the study, 86 (43.4%) were diabetic and 112 (56.5%) were non-diabetic. Majority of the patients were males 139 (70.2%) with a mean age of 54.14±14.89 years. In-hospital mortality rate was higher in diabetic patients than in non-diabetic patients (40 vs. 32; =0.011). The most common comorbidity was hypertension (n=95, 48%) followed by ischemic heart disease (n=35, 17.7%), chronic kidney disease (n=17, 9.6%), and bronchial asthma (n=10, 5.1%). The risk of SARS-CoV-2 infection is higher among diabetic patients; particularly, those with preexisting co-morbidities or geriatric patients. Diabetic patients are prone to a severe clinical course of COVID-19 and a significantly higher mortality rate.
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2023.44.1.20220462