Search Results - "Jason Chibuk"

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients by Rafalko, Jill M, Kruglyak, Kristina M, McCleary-Wheeler, Angela L, Goyal, Vidit, Phelps-Dunn, Ashley, Wong, Lilian K, Warren, Chelsea D, Brandstetter, Gina, Rosentel, Michelle C, DiMarzio, Lauren, McLennan, Lisa M, O'Kell, Allison L, Cohen, Todd A, Grosu, Daniel S, Chibuk, Jason, Tsui, Dana W Y, Chorny, Ilya, Flory, Andi

“…The goal of cancer screening is to detect disease at an early stage when treatment may be more effective. Cancer screening in dogs has relied upon annual…”
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A new era in aneuploidy screening: cfDNA testing in >30,000 multifetal gestations: Experience at one clinical laboratory by Dyr, Brittany, Boomer, Theresa, Almasri, Eyad A, Wardrop, Jenna L, Rafalko, Jill, Chibuk, Jason, McCullough, Ron M

“…Since introducing cell-free DNA screening, Sequenom Laboratories has analyzed over 1 million clinical samples. More than 30,000 of these samples were from…”
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Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs by Flory, Andi, McLennan, Lisa, Peet, Betsy, Kroll, Marissa, Stuart, Deirdre, Brown, Devon, Stuebner, Kathy, Phillips, Brenda, Coomber, Brenda L., Woods, J. Paul, Miller, Mairin, Tripp, Chelsea D., Wolf‐Ringwall, Amber, Kruglyak, Kristina M., McCleary‐Wheeler, Angela L., Phelps‐Dunn, Ashley, Wong, Lilian K., Warren, Chelsea D., Brandstetter, Gina, Rosentel, Michelle C., DiMarzio, Lauren R., O'Kell, Allison L., Cohen, Todd A., Grosu, Daniel S., Chibuk, Jason, Tsui, Dana W. Y., Chorny, Ilya, Rafalko, Jill M.

“…Background Guidelines‐driven screening protocols for early cancer detection in dogs are lacking, and cancer often is detected at advanced stages…”
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Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs by Chibuk, Jason, Flory, Andi, Kruglyak, Kristina M, Leibman, Nicole, Nahama, Alexis, Dharajiya, Nilesh, van den Boom, Dirk, Jensen, Taylor J, Friedman, Jeffrey S, Shen, M Richard, Clemente-Vicario, Francisco, Chorny, Ilya, Tynan, John A, Lytle, Katherine M, Holtvoigt, Lauren E, Murtaza, Muhammed, Diaz, Jr, Luis A, Tsui, Dana W Y, Grosu, Daniel S

“…Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis…”
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Blood-Based Liquid Biopsy for Comprehensive Cancer Genomic Profiling Using Next-Generation Sequencing: An Emerging Paradigm for Non-invasive Cancer Detection and Management in Dogs by Kruglyak, Kristina M, Chibuk, Jason, McLennan, Lisa, Nakashe, Prachi, Hernandez, Gilberto E, Motalli-Pepio, Rita, Fath, Donna M, Tynan, John A, Holtvoigt, Lauren E, Chorny, Ilya, Grosu, Daniel S, Tsui, Dana W Y, Flory, Andi

“…This proof-of-concept study demonstrates that blood-based liquid biopsy using next generation sequencing of cell-free DNA can non-invasively detect multiple…”
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Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs by Kruglyak, Kristina M, O'Kell, Allison L, Cohen, Todd A, Marshall, Maggie A, Ruiz-Perez, Carlos A, Marass, Francesco, Tynan, John A, Hicks, Susan C, Lytle, Katherine M, Phelps-Dunn, Ashley, Brandstetter, Gina, Warren, Chelsea D, DiMarzio, Lauren R, Rosentel, Michelle C, Wong, Lilian K, McLennan, Lisa M, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, Chorny, Ilya, McCleary-Wheeler, Angela L, Flory, Andi, Tsui, Dana W Y

“…Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied…”
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Mosaic ACVRL1 and ENG mutations in hereditary haemorrhagic telangiectasia patients by Best, D Hunter, Vaughn, Cecily, McDonald, Jamie, Damjanovich, Kristy, Runo, James R, Chibuk, Jason M, Bayrak-Toydemir, Pinar

“…Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder caused by mutations in the ACVRL1, ENG, and SMAD4 genes. HHT is commonly…”
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Three years of clinical experience with a genome-wide cfDNA screening test for aneuploidies and copy-number variants by Soster, Erica, Boomer, Theresa, Hicks, Susan, Caldwell, Samantha, Dyr, Brittany, Chibuk, Jason, Almasri, Eyad

“…Pregnant women have unprecedented choices for prenatal screening and testing. Cell-free DNA (cfDNA) offers the option to screen for aneuploidy of all…”
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Genome-wide cfDNA screening: clinical laboratory experience with the first 10,000 cases by Ehrich, Mathias, Tynan, John, Mazloom, Amin, Almasri, Eyad, McCullough, Ron, Boomer, Theresa, Grosu, Daniel, Chibuk, Jason

“…Purpose Invasive diagnostic prenatal testing can provide the most comprehensive information about the genetic status of a fetus. Noninvasive prenatal screening…”
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Cell‐free DNA screening in twin pregnancies: A more accurate and reliable screening tool by Chibuk, Jason, Rafalko, Jill, Boomer, Theresa, McCullough, Ron, McLennan, Graham, Wyatt, Philip, Almasri, Eyad

“…Objective Outcome data from cell‐free DNA (cfDNA) screening in twin gestations are limited. This study adds an appreciable number of confirmed outcomes to the…”
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Correction to: Three years of clinical experience with a genome-wide cfDNA screening test for aneuploidies and copy number variants by Soster, Erica, Boomer, Theresa, Hicks, Susan, Caldwell, Samantha, Dyr, Brittany, Chibuk, Jason, Almasri, Eyad

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Analysis of Liquid Biopsy Performance for the Detection of Lymphoma in Dogs with a Focus on Recurrent Copy Number Variants in Matched Plasma and Lymph Node Aspirates: Implications for a Comparative Oncology Model by Chorny, Ilya, McCleary-Wheeler, Angela L, Flory, Andi, Kruglyak, Kristina M, Rafalko, Jill M, Grosu, Daniel S, O'Kell, Allison L, Cohen, Todd A, Chibuk, Jason, Hicks, Susan C, Tynan, John A, Tsui, Dana WY

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Comparative oncology analysis using genomic profiling of canine cancers by tissue and liquid biopsy testing reveals actionable somatic alterations with orthologs in human cancers by Tsui, Dana, Chorny, Ilya, Kruglyak, Kristina M, Tynan, John A., Hernandez, Gilberto E, Nakashe, Prachi, Hicks, Susan Cho, Motalli-Pepio, Rita, McLennan, Lisa M., Holtvoigt, Lauren E., Rafalko, Jill M., Chibuk, Jason, McCleary-Wheeler, Angela L., Flory, Andi, Grosu, Daniel S.

“…e15012 Background: Targeted therapies offer great potential for cancer treatment in humans; however, enrollment in clinical trials may be slow, particularly…”
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Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study by Flory, Andi, Kruglyak, Kristina M, Tynan, John A, McLennan, Lisa M, Rafalko, Jill M, Fiaux, Patrick Christian, Hernandez, Gilberto E, Marass, Francesco, Nakashe, Prachi, Ruiz-Perez, Carlos A, Fath, Donna M, Jennings, Thuy, Motalli-Pepio, Rita, Wotrang, Kate, McCleary-Wheeler, Angela L, Lana, Susan, Phillips, Brenda, Flesner, Brian K, Leibman, Nicole F, LaDue, Tracy, Tripp, Chelsea D, Coomber, Brenda L, Woods, J Paul, Miller, Mairin, Aiken, Sean W, Wolf-Ringwall, Amber, Borgatti, Antonella, Kraska, Kathleen, Thomson, Christopher B, Kosanovich Cahalane, Alane, Murray, Rebecca L, Kisseberth, William C, Camps-Palau, Maria A, Floch, Franck, Beaudu-Lange, Claire, Klajer-Peres, Aurélia, Keravel, Olivier, Fribourg-Blanc, Luc-André, Mazetier, Pascale Chicha, Marco, Angelo, McLeod, Molly B, Portillo, Erin, Clark, Terry S, Judd, Scott, Feinberg, C Kirk, Benitez, Marie, Runyan, Candace, Hackett, Lindsey, Lafey, Scott, Richardson, Danielle, Vineyard, Sarah, Tefend Campbell, Mary, Dharajiya, Nilesh, Jensen, Taylor J, van den Boom, Dirk, Diaz, Jr, Luis A, Grosu, Daniel S, Polk, Arthur, Marsal, Kalle, Hicks, Susan Cho, Lytle, Katherine M, Holtvoigt, Lauren, Chibuk, Jason, Chorny, Ilya, Tsui, Dana W Y

“…Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate…”
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Clinical validation of a blood-based liquid biopsy test integrating cell-free DNA quantification and next-generation sequencing for cancer screening in dogs by Flory, Andi, Ruiz-Perez, Carlos A, Clavere-Graciette, Ana G, Rafalko, Jill M, O'Kell, Allison L, Flesner, Brian K, McLennan, Lisa M, Hicks, Susan C, Nakashe, Prachi, Phelps-Dunn, Ashley, DiMarzio, Lauren R, Warren, Chelsea D, Cohen, Todd A, Chibuk, Jason, Chorny, Ilya, Grosu, Daniel S, Tsui, Dana W Y, Tynan, John A, Kruglyak, Kristina M

“…To validate the performance of a novel, integrated test for canine cancer screening that combines cell-free DNA quantification with next-generation sequencing…”
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Next-generation sequencing-based liquid biopsy may be used for detection of residual disease and cancer recurrence monitoring in dogs by McCleary-Wheeler, Angela L, Fiaux, Patrick C, Flesner, Brian K, Ruiz-Perez, Carlos A, McLennan, Lisa M, Tynan, John A, Hicks, Susan C, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, O'Kell, Allison L, Cohen, Todd A, Chorny, Ilya, Tsui, Dana W Y, Kruglyak, Kristina M, Flory, Andi

“…The purpose of this study was to evaluate the performance of a next-generation sequencing-based liquid biopsy test for cancer monitoring in dogs. Pre- and…”
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Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs by Flory, Andi, Kruglyak, Kristina M, Tynan, John A, McLennan, Lisa M, Rafalko, Jill M, Fiaux, Patrick Christian, Hernandez, Gilberto E, Marass, Francesco, Nakashe, Prachi, Ruiz-Perez, Carlos A, Fath, Donna M, Jennings, Thuy, Motalli-Pepio, Rita, Wotrang, Kate, McCleary-Wheeler, Angela L, Lana, Susan, Phillips, Brenda, Flesner, Brian K, Leibman, Nicole F, LaDue, Tracy, Tripp, Chelsea D, Coomber, Brenda L, Woods, J. Paul, Miller, Mairin, Aiken, Sean W, Wolf-Ringwall, Amber, Borgatti, Antonella, Kraska, Kathleen, Thomson, Christopher B, Kosanovich Cahalane, Alane, Murray, Rebecca L, Kisseberth, William C, Camps-Palau, Maria A, Floch, Franck, Beaudu-Lange, Claire, Klajer-Peres, Aurélia, Keravel, Olivier, Fribourg-Blanc, Luc-André, Mazetier, Pascale Chicha, Marco, Angelo, McLeod, Molly B, Portillo, Erin, Clark, Terry S, Judd, Scott, Feinberg, C. Kirk, Benitez, Marie, Runyan, Candace, Hackett, Lindsey, Lafey, Scott, Richardson, Danielle, Vineyard, Sarah, Tefend Campbell, Mary, Dharajiya, Nilesh, Jensen, Taylor J, van den Boom, Dirk, Diaz, Luis A, Grosu, Daniel S, Polk, Arthur, Marsal, Kalle, Hicks, Susan Cho, Lytle, Katherine M, Holtvoigt, Lauren, Chibuk, Jason, Chorny, Ilya, Tsui, Dana W. Y

“…Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate…”
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Clinical experience with next-generation sequencing-based liquid biopsy testing for cancer detection in dogs: a review of 1,500 consecutive clinical cases by O'Kell, Allison L, Lytle, Katherine M, Cohen, Todd A, Wong, Lilian K, Sandford, Emily, Rafalko, Jill M, Brandstetter, Gina, DiMarzio, Lauren R, Phelps-Dunn, Ashley, Rosentel, Michelle C, Warren, Chelsea D, McCleary-Wheeler, Angela L, Fiaux, Patrick C, Marass, Francesco, Marshall, Maggie A, Ruiz-Perez, Carlos A, Kruglyak, Kristina M, Tynan, John A, Hicks, Susan C, Grosu, Daniel S, Chibuk, Jason, Chorny, Ilya, Tsui, Dana W Y, Flory, Andi

“…To review ordering patterns, positivity rates, and outcome data for a subset of consecutive samples submitted for a commercially available, blood-based…”
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Abstract 3377: Liquid biopsy analysis reveals orthologs of actionable human cancer variants in dogs by Grosu, Daniel S., Chorny, Ilya, Kruglyak, Kristina M., Tynan, John A., Hicks, Susan C., Cohen, Todd A., O'Kell, Allison L., Rafalko, Jill M., Chibuk, Jason, McCleary-Wheeler, Angela L., Flory, Andi, Tsui, Dana W.

“…Abstract Genotype-matched therapeutics have become widely adopted in the management of human cancers and can be guided by testing tumor tissue or cell-free DNA…”
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Abstract 1612: Comparative oncology analysis of canine cancer by tumor and liquid biopsy testing for biomarker and therapeutic discovery in humans and dogs by Chorny, Ilya, Kruglyak, Kristina M., Tynan, John A., Hernandez, Gilberto E., Nakashe, Prachi, Hicks, Susan, Motalli-Pepio, Rita, McLennan, Lisa, Holtvoigt, Lauren E., Rafalko, Jill M., Chibuk, Jason, McCleary-Wheeler, Angela L., Flory, Andi, Grosu, Daniel S., Tsui, Dana W.

“…Abstract Human and canine cancers share a high level of homology. Characterizing their respective genomic landscapes can expand the knowledge base of…”
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